Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ

(2016) Jinbiao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The effect of altered sphingolipid acyl chain length on various disease models

(2015) Woo-Jae Park et al.   BIOLOGICAL CHEMISTRY

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors

(2015) Mariona Rabionet et al.   HUMAN MOLECULAR GENETICS

Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling

(2015) Franziska Peters et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

(2014) Philipp Ebel et al.   BIOCHEMICAL JOURNAL

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities

(2013) Philipp Ebel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays

(2013) Anne Gaebler et al.   JOURNAL OF LIPID RESEARCH

The role of lipid metabolism in the acquisition of desiccation tolerance inCraterostigma plantagineum: a comparative approach

(2013) Francisco Gasulla et al.   PLANT JOURNAL

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

(2012) Christina Ginkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Ceramide Synthase Activity via Dimerization

(2012) Elad L. Laviad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

A fluorescent assay for ceramide synthase activity

(2012) Hyun Joon Kim et al.   JOURNAL OF LIPID RESEARCH

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Inhibitors of specific ceramide synthases

(2011) Susanne Schiffmann et al.   BIOCHIMIE

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain

(2011) Rotem Tidhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+and ER/Golgi Membrane Network

(2011) Can E. Senkal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death

(2011) Thomas D. Mullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantification of sterol lipids in plants by quadrupole time-of-flight mass spectrometry

(2011) Vera Wewer et al.   JOURNAL OF LIPID RESEARCH

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Chain length-specific properties of ceramides

(2011) Sabine Grösch et al.   PROGRESS IN LIPID RESEARCH

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

(2010) Judith Mesicek et al.   CELLULAR SIGNALLING

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

(2010) Yael Pewzner-Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

(2010) Yael Pewzner-Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

(2009) Reinhard Bauer et al.   EMBO JOURNAL

Acylcarnitine profile analysis

(2009) Piero Rinaldo et al.   GENETICS IN MEDICINE

Technical note: An R package for fitting generalized linear mixed models in animal breeding1

(2009) A. I. Vazquez et al.   JOURNAL OF ANIMAL SCIENCE

Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas

(2009) Silke Imgrund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1

(2008) Charmi Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry

(2008) Christopher A. Haynes et al.   JOURNAL OF LIPID RESEARCH

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE