The Premature Senescence in Breast Cancer Treatment Strategy

Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement

(2020) Vida Celeste Rosas‐González et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells

(2019) Martina S.J. McDermott et al.   Cancers

Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment

(2019) Jordan Guillon et al.   Cell Death & Disease

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A

(2019) Jin-Gang Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer

(2019) Tingting Yin et al.   CANCER RESEARCH

Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression

(2019) Li-Ming Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence

(2019) Ding Wu et al.   BMC GENOMICS

Dual inhibition of Akt and ERK signaling induces cell senescence in triple-negative breast cancer

(2019) Qiang He et al.   CANCER LETTERS

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

(2019) Vladislav Korobeynikov et al.   BREAST CANCER RESEARCH AND TREATMENT

Different sensitivities of senescent breast cancer cells to immune cell‐mediated cytotoxicity

(2019) Touko Inao et al.   CANCER SCIENCE

ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation

(2019) Luciana Rodrigues Gomes et al.   Cell Death & Disease

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

(2019) Hubert Fleury et al.   Nature Communications

Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells

(2019) Justyna Mikuła-Pietrasik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance

(2019) David P. Hill et al.   BMC CANCER

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

(2018) Harshal Nemade et al.   ARCHIVES OF TOXICOLOGY

Emerging therapeutic modalities of PARP inhibitors in breast cancer

(2018) Xin Wang et al.   CANCER TREATMENT REVIEWS

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

(2018) Małgorzata Milczarek et al.   FOOD AND CHEMICAL TOXICOLOGY

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Metronomic combination of vinorelbine and 5Fluorouracil inhibit triple-negative breast cancer cells results from the proof-of-concept VICTOR-0 study

(2018) Maria Grazia Cerrito et al.   Oncotarget

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB

(2018) Simona Camorani et al.   Oncotarget

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

(2018) Tareq Saleh et al.   Frontiers in Oncology

Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence

(2018) Yan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells

(2018) Hilal Taymaz-Nikerel et al.   Scientific Reports

Tumor cell escape from therapy-induced senescence

(2018) Tareq Saleh et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

(2018) Jingyi Liu et al.   Nature Communications

Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A

(2017) Ariane Chan et al.   INVESTIGATIONAL NEW DRUGS

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity

(2017) Anna Lewinska et al.   TOXICOLOGY LETTERS

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Downregulation of Bmi1 in breast cancer stem cells suppresses tumor growth and proliferation

(2017) Mathangi Srinivasan et al.   Oncotarget

Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells

(2017) Anna Lewinska et al.   Theranostics

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells

(2017) E L Kavanagh et al.   Oncogenesis

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

(2017) Kevin M. Perrott et al.   GeroScience

Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21waf-1

(2016) Souneek Chakraborty et al.   AGE

Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence

(2016) Jun He et al.   ANTI-CANCER DRUGS

Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy

(2016) Yijuan Zhang et al.   BIOMATERIALS

Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases

(2016) M Thorn et al.   CANCER GENE THERAPY

Curcumin-treated cancer cells show mitotic disturbances leading to growth arrest and induction of senescence phenotype

(2016) Grażyna Mosieniak et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells

(2016) Lisha Xie et al.   OncoTargets and Therapy

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

(2016) Michael J. Lukey et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer

(2016) Raghavendra A. Shamanna et al.   Oncotarget

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Matrix metalloproteinases as drivers and therapeutic targets in breast cancer

(2015) Evette S. Radisky   Frontiers in Bioscience-Landmark

p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer

(2015) J. J. Tentler et al.   MOLECULAR CANCER THERAPEUTICS

Long Term Exposure to Polyphenols of Artichoke (Cynara scolymusL.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line

(2015) Anna Maria Mileo et al.   Oxidative Medicine and Cellular Longevity

Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation

(2015) Hussain El Hasasna et al.   Scientific Reports

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs

(2014) Sonia C. Dolfi et al.   CANCER LETTERS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways

(2014) Ying-Bo Li et al.   Pharmacological Reports

Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?

(2014) P Meng et al.   Cell Death & Disease

New Nucleophilic Mechanisms of Ros-Dependent Epigenetic Modifications: Comparison of Aging and Cancer

(2014) Igor Afanas’ev   Aging and Disease

Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation

(2013) Yusra Al Dhaheri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antitumor effect of novel berberine derivatives in breast cancer cells

(2013) Elisa Pierpaoli et al.   BIOFACTORS

Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling

(2013) Chun Wang et al.   CARCINOGENESIS

Effect of annatto-tocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice

(2013) E. Pierpaoli et al.   CARCINOGENESIS

Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells

(2013) Young-Hoon Lee et al.   FOOD CHEMISTRY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Premature senescence in human breast cancer and colon cancer cells by tamoxifen-mediated reactive oxygen species generation

(2013) Young-Hoon Lee et al.   LIFE SCIENCES

Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1

(2013) Anni Laine et al.   Cancer Discovery

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells

(2012) Hiu‑Fung Yuen et al.   BIOSCIENCE REPORTS

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells

(2012) CHIEN-CHIH YU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence

(2011) Rebecca Tuttle et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of VEGF induces cellular senescence in colorectal cancer cells

(2011) Mohammad R. Hasan et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials

(2011)   LANCET

DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs

(2011) Ah-Young So et al.   PLoS One

The emerging role of CXCL10 in cancer (Review)

(2011) MINGLI LIU et al.   Oncology Letters

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

YPEL3, a p53-Regulated Gene that Induces Cellular Senescence

(2010) Kevin D. Kelley et al.   CANCER RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers

(2009) M. Santarosa et al.   MOLECULAR CANCER THERAPEUTICS