Article
Toxicology
Eduardo Cremonese Filippi-Chiela, Jose Eduardo Vargas, Mardja Manssur Bueno E. Silva, Marcos Paulo Thome, Guido Lenz
Summary: This study investigated the effects of Vincristine (VCR) on glioblastoma cells, finding strong negative correlations between cell number, nuclear irregularities, senescence, or apoptosis depending on genetic makeup and treatment regimen. Topological network analysis revealed the importance of P53 in all analyzed processes. Despite acute sensitivity, both cell lines regrew in the long term after a single VCR treatment, especially in populations with high levels of autophagy.
TOXICOLOGY IN VITRO
(2022)
Article
Cell Biology
Taichi Nyui, Hironori Yoshino, Tetsuya Nunota, Yoshiaki Sato, Eichi Tsuruga
Summary: cGAS has a role in promoting radioresistance in HNSCC cells, as its knockdown enhances radiosensitivity and increases radiation-induced cell death and senescence.
Article
Biochemistry & Molecular Biology
Zhaoshi Bai, Yiran Zhou, Xinyue Ye, Yupeng Li, Yaling Peng, Qi Guan, Weige Zhang, Lingman Ma
Summary: Research has shown that BZML can induce p53-dependent senescence in MDR cells, demonstrating an anticancer effect. This senescence is a secondary effect of MC in overcoming MDR. During MC, BZML-induced disruption of the protein-degradation system leads to an increase in p53 protein and the accumulation of survivin in the nucleus of cells. The nuclear accumulation of survivin is a result, not an inducer of BZML-induced MC, promoting the survival of senescent cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Biology
Elena V. Sazonova, Svetlana V. Petrichuk, Gelina S. Kopeina, Boris Zhivotovsky
Summary: Mitotic catastrophe, a cell death mechanism linked to delayed mitosis, may result in apoptosis, necrosis, or autophagy depending on molecular perturbations. Associated with cell aging and tumor elimination, effective triggering in clinical practice requires induction of DNA damage and inhibition of molecular pathways.
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Review
Pharmacology & Pharmacy
Hao Yang, Shan Xu, Lidan Tang, Jinhong Gong, Hufeng Fang, Jifu Wei, Dan Su
Summary: This review summarizes the current status of research on the molecular mechanisms and targets of quercetin-mediated non-apoptotic cell death modes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thomas von Zglinicki, Tengfei Wan, Satomi Miwa
Summary: Cell senescence is not limited to proliferating cells, but can also occur in non-dividing cells. Different senescence domains interact with each other and may play a significant role in mammalian aging.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ines Milagre, Carolina Pereira, Raquel A. Oliveira
Summary: Human pluripotent stem cells (PSCs), including embryonic and induced pluripotent stem cells, are widely used in biomedical research for understanding development, disease progression, and drug discovery. However, concerns have been raised regarding their safety in regenerative medicine, particularly due to the occurrence of aneuploid cells resulting from errors in chromosome segregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Moloudi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najafi
Summary: Inducing cell death and inhibiting cell proliferation in cancer is important in anti-tumor therapy. Apigenin, a nature-derived and herbal agent, has shown anticancer properties by directly inducing cell death and enhancing the induction of cell death through other anti-tumor modalities. It can induce various types of cell death, such as apoptosis, autophagic cell death, senescence, anoikis, necroptosis, and ferroptosis. The modulatory actions of apigenin enhance anticancer effects and may be dependent on the type of cancer. Overall rating: 8/10.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Zicheng Wang, Yanqing Liu, Ahmed Eleojo Musa
Summary: Cancer therapy is aimed at killing cancer cells using various therapeutic agents. Melatonin, a circadian regulator hormone, has the potential to activate tumor suppressor genes and attenuate the expression of survival genes in cancer cells. Modulating disrupted or overexpressed cell death or survival genes in cancer cells can improve cancer therapy.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Orawan Waenphimai, Panupong Mahalapbutr, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth
Summary: The potent inhibitor NMS-P715 showed multiple anti-cancer effects in human CCA cell lines, including inhibiting cell proliferation and colony formation, inducing G2/M arrest, mitotic catastrophe, caspase-dependent apoptosis, autophagosome formation, and suppressing cell migration and invasion. The study suggests that NMS-P715 may have potential for further development in clinical studies as a promising candidate for combating CCA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yingjie Shen, Hyoung Jae Lee, Rui Zhou, Hangun Kim, Gen Chen, Young-Chang Cho, Kwonseop Kim
Summary: Delta-catenin plays a crucial role in prostate cancer by inducing phosphorylation of p21 and stabilizing it in the cytoplasm, thus inhibiting its nuclear accumulation. It also regulates the interaction between AKT and p21, leading to the phosphorylation of p21 at Thr-145 residue, ultimately promoting proliferation and metastasis in prostate cancer through the EGF signaling pathway. These findings provide new insights into potential therapeutics targeting delta-catenin for controlling prostate cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Miguel Santibanez-Andrade, Yesennia Sanchez-Perez, Yolanda Chirino, Rocio Morales-Barcenas, Raul Quintana-Belmares, Claudia M. Garcia-Cuellar
Summary: This study found that PM10 regulates SETD2 and SAC components in A549 lung cancer cells, leading to abnormal mitotic process and chromosomal instability.
Article
Biochemistry & Molecular Biology
Zimei Yi, Le Ren, Yu Wei, Siyi Chen, Jiechen Zhao, Jiayu Zhu, Junhua Wu
Summary: By building a p21-3MR mouse model, we were able to study the contribution of cells with high p21 expression to tissue dysfunction in aging, obesity, and other pathological conditions, and found that clearing these cells improved multi-organ toxicity. This study is of great importance in further understanding the biology of cell senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sylvia Mansilla, Carolina Vizcaino, Maria A. Rodriguez-Sanchez, Waldemar Priebe, Jose Portugal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2015)
Review
Pharmacology & Pharmacy
Carolina Vizcaino, Sylvia Mansilla, Jose Portugal
PHARMACOLOGY & THERAPEUTICS
(2015)
Article
Toxicology
Carolina Vizcaino, Maria A. Rodriguez-Sanchez, Luz-Elena Nunez, Francisco Moris, Jose Portugal
TOXICOLOGY IN VITRO
(2015)
Review
Biochemistry & Molecular Biology
Jose Portugal, Francisca Barcelo
CURRENT MEDICINAL CHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Jose Portugal
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Francisca Barcelo, Rosa Gomila, Ivan de Paul, Xavier Gili, Jaume Segura, Albert Perez-Montana, Teresa Jimenez-Marco, Antonia Sampol, Jose Portugal
Review
Biochemistry & Molecular Biology
Jose Portugal
Summary: This article highlights the significance of classic DNA-binding drugs in cancer therapy and their ability to alter gene expression, explaining current research directions and future developments. It also discusses how omic techniques and genome-wide approaches are providing valuable insights into the effects of antitumor drugs, with large-scale genomic studies contributing to the development of precision medicine in cancer treatment.
Article
Engineering, Environmental
V. Matamoros, M. Escola Casas, S. Mansilla, D. Tadic, N. Canameras, N. Carazo, J. Portugal, B. Pina, S. Diez, J. M. Bayona
Summary: This study conducted a plot-scale research on crop cultivation using organic fertilizers containing antibiotics and found that while organic fertilizers increased the concentration of antibiotics in lettuce leaves, it did not pose a risk to human health.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Environmental Sciences
Ilias Vouitsis, Jose Portugal, Anastasios Kontses, Hanna L. Karlsson, Melissa Faria, Karine Elihn, Ana Teresa Juarez-Facio, Fulvio Amato, Benjamin Pina, Zisis Samaras
Summary: Nanoparticle emissions from transport are a major concern due to their high concentration and potential health risks. This paper reviews the different aerosol modes produced by various transport sources, such as road, shipping, aviation, and rail, and investigates their toxicity effects. It concludes that transport sources emit a large number of nanoparticles that can damage the respiratory tract, lungs, and other organs, leading to systemic toxicity.
ATMOSPHERIC ENVIRONMENT
(2023)
Review
Environmental Sciences
N. V. Srikanth Vallabani, Olena Gruzieva, Karine Elihn, Ana Teresa Juarez-Facio, Sarah S. Steimer, Jana Kuhn, Sanna Silvergren, Jose Portugal, Benjamin Pina, Ulf Olofsson, Christer Johansson, Hanna L. Karlsson
Summary: This literature review summarizes toxicological and epidemiological studies of ultrafine particles (UFPs) from different transport modes, including vehicle exhaust, non-exhaust, shipping, aviation, and rail. The results suggest that particles from both fossil and biodiesel sources exhibit toxic effects, with impacts on the lung, cardiovascular system, and brain. Further research is needed to better understand the relative toxicity of UFPs from different transport modes and their implications for health risk assessment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Sylvia Mansilla, Benjamin Pin, Jose Portugal, Iakovos C. Iakovides, Vasiliki G. Beretsou, Anastasis Christou, Despo Fatta-Kassinos, Josep M. Bayona, Victor Matamoros
Summary: This study analyzed the impact of contaminants of emerging concern (CECs) in reclaimed water on lettuce. The results showed that irrigation with reclaimed water increased the concentration of metabolites and stress-related gene transcripts in lettuce, with MBR-reclaimed water having the strongest effect.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Review
Biochemistry & Molecular Biology
Jose Portugal, Sylvia Mansilla, Benjamin Pina
Summary: Environmental toxicogenomics aims to analyze and interpret changes in gene expression and protein activity resulting from exposure to toxic substances. It can detect patterns and mechanisms of toxicity and identify specific gene expression profiles as biomarkers of exposure and risk.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Engineering, Environmental
Sylvia Mansilla, Jose Portugal, Josep M. Bayona, Victor Matamoros, Ana Maria Leiva, Gladys Vidal, Benjamin Pina
Summary: Global crop production is limited by water, nitrogen, and phosphorous availability. The use of reclaimed water and organic fertilizers can help mitigate these needs, but they may contain pollutants from various sources. The PRIMA-DSWAP project aims to assess the risks associated with these practices and explore technical measures to minimize impacts, particularly focusing on the presence of emerging contaminants and their potential effects on crop performance and quality.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Jose Portugal
Summary: This article discusses the importance of DNA-binding drugs in cancer chemotherapy, as well as the role of various omic techniques in revealing the effects of drugs and cellular responses. The results of genomic studies are also mentioned as providing important references for the application of precision medicine in cancer treatment.
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
