Hepatocyte polyploidization and its association with pathophysiological processes

MicroRNA-122 regulates polyploidization in the murine liver

(2016) Shu-hao Hsu et al.   HEPATOLOGY

The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry

(2016) Alina Simerzin et al.   HEPATOLOGY

Regulation of cytokinesis and its clinical significance

(2015) Ana M. Tormos et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Pathological polyploidy in liver disease

(2015) Shu-hao Hsu et al.   HEPATOLOGY

Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase

(2015) Se-Hyuk Kim et al.   HEPATOLOGY

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

(2015) Géraldine Gentric et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-122 – A key factor and therapeutic target in liver disease

(2015) Simonetta Bandiera et al.   JOURNAL OF HEPATOLOGY

Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells

(2015) Jialin He et al.   Molecular Cancer

Liver polyploidy: Dr Jekyll or Mr Hide?

(2015) Géraldine Gentric et al.   Oncotarget

Reversal of hepatocyte senescence after continuousin vivocell proliferation

(2014) Min-Jun Wang et al.   HEPATOLOGY

Loss of Survivin influences liver regeneration and is associated with impaired Aurora B function

(2013) S Hagemann et al.   CELL DEATH AND DIFFERENTIATION

Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice

(2013) Dan Li et al.   HEPATOLOGY

p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver

(2013) Svitlana Kurinna et al.   HEPATOLOGY

Physiological significance of polyploidization in mammalian cells

(2013) Shusil K. Pandit et al.   TRENDS IN CELL BIOLOGY

Tetraploidization increases sensitivity to Aurora B kinase inhibition

(2012) Miriam Marxer et al.   CELL CYCLE

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p

(2012) Shuliang Chen et al.   NATURE CELL BIOLOGY

E2F8 is essential for polyploidization in mammalian cells

(2012) Shusil K. Pandit et al.   NATURE CELL BIOLOGY

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network calisthenics

(2011) Jeffrey V. Wong et al.   CELL CYCLE

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Human hepatic stem cell and maturational liver lineage biology

(2011) Rachael Turner et al.   HEPATOLOGY

Polyploidy and liver proliferation

(2011) G. Gentric et al.   Clinics and Research in Hepatology and Gastroenterology

Polyploidy and liver proliferation: Central role of insulin signaling

(2010) Séverine Celton-Morizur et al.   CELL CYCLE

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Somatic polyploidy promotes cell function under stress and energy depletion: evidence from tissue-specific mammal transcriptome

(2010) Olga V. Anatskaya et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin

(2009) Yulia A. Nevzorova et al.   GASTROENTEROLOGY

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma

(2009) Arihiro Aihara et al.   JOURNAL OF HEPATOLOGY

Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy

(2009) Zakir Ullah et al.   Cell Division