Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy

Polyphenols from Food and Natural Products: Neuroprotection and Safety

(2020) Rui F. M. Silva et al.   Antioxidants

ROS induced p53 activation: DNA damage, redox signaling or both?

(2020) Tao Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease

(2020) Peng Yang et al.   BIOMATERIALS

Protection of human retinal pigment epithelial cells from oxidative damage using cysteine prodrugs

(2020) Ruvanthi N. Kularatne et al.   FREE RADICAL BIOLOGY AND MEDICINE

CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage

(2020) Jihong Xing et al.   Neurodegenerative Diseases

Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis

(2020) Lisen Lu et al.   BIOMATERIALS

Glycyrrhizic acid protects juvenile epileptic rats against hippocampal damage through activation of Sirtuin3

(2020) Gang Wu et al.   BRAIN RESEARCH BULLETIN

The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin

(2020) Shanshan Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy

(2020) Humna Bhagani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Developmental lead (Pb)-induced deficits in redox and bioenergetic status of cerebellar synapses are ameliorated by ascorbate supplementation

(2020) Faraz Ahmad et al.   TOXICOLOGY

Untargeted Metabolomics Identifies Key Metabolic Pathways Altered by Thymoquinone in Leukemic Cancer Cells

(2020) Asma Ahmed AlGhamdi et al.   Nutrients

Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Mitochondrial Dynamics/Mitophagy in Neurological Diseases

(2020) Tae-Cheon Kang   Antioxidants

Mitochondrial Dysfunction and DNA Damage in the Context of Pathogenesis of Atherosclerosis

(2020) Taisiia Shemiakova et al.   Biomedicines

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation

(2020) Simone C. da Silva Rosa et al.   Autophagy

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

(2020) Anindya Roy Chowdhury et al.   Redox Biology

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway

(2019) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

(2019) Ruth Scherz‐Shouval et al.   EMBO JOURNAL

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)

(2019) Kai Kaarniranta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox-Related Neuronal Death and Crosstalk as Drug Targets: Focus on Epilepsy

(2019) Xiao-Yuan Mao et al.   Frontiers in Neuroscience

Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

(2019) Sha Xiong et al.   Asian Journal of Pharmaceutical Sciences

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

(2019) Chaojun Yan et al.   Autophagy

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Peroxiredoxin 5 inhibits glutamate-induced neuronal cell death through the regulation of calcineurin-dependent mitochondrial dynamics in HT22 cells.

(2019) Mi Hye Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondria Re-set Epilepsy

(2019) Valerie Uytterhoeven et al.   NEURON

Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction

(2019) Passakorn Sawaddiruk et al.   FREE RADICAL RESEARCH

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction

(2019) Wei Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy

(2019) Carlos Roberto Porto Dechandt et al.   Frontiers in Neurology

Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy

(2019) Tawfeeq Shekh-Ahmad et al.   Redox Biology

Mitochondria as central hub of the immune system

(2019) Cristiane Naffah de Souza Breda et al.   Redox Biology

Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice

(2019) Yahong Cheng et al.   BIOCHEMICAL PHARMACOLOGY

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks

(2019) Jun Tan et al.   NUCLEIC ACIDS RESEARCH

NADPH oxidase 2 derived ROS contributes to LTP of C-fiber evoked field potentials in spinal dorsal horn and persistent mirror-image pain following high frequency stimulus of the sciatic nerve

(2019) Jing Xu et al.   PAIN

Effect of exposure to phthalates on association of polycyclic aromatic hydrocarbons with 8-hydroxy-2′-deoxyguanosine

(2019) Jian Hou et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response

(2019) Fabio Ciccarone et al.   BRITISH JOURNAL OF CANCER

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected

(2019) Cailing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model

(2019) Yurong Zhang et al.   Redox Biology

The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling

(2019) Xuewu Sun et al.   Redox Biology

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy

(2018) Lindsey B. Gano et al.   FREE RADICAL BIOLOGY AND MEDICINE

N -acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease

(2018) Erzsebet Polyak et al.   MOLECULAR GENETICS AND METABOLISM

Effect of Resveratrol on Oxidative Stress and Mitochondrial Dysfunction in Immature Brain during Epileptogenesis

(2018) Jaroslava Folbergrová et al.   MOLECULAR NEUROBIOLOGY

The Oral Bioavailability of Trans -Resveratrol from a Grapevine-Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization

(2018) Laura A. Calvo-Castro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus

(2018) Inja Cho et al.   NEUROCHEMICAL RESEARCH

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

(2018) Nisi Zhang et al.   Theranostics

The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?

(2018) Adrian L Lopresti   Advances in Nutrition

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Zinc/CaMK II Associated-Mitophagy Signaling Contributed to Hippocampal Mossy Fiber Sprouting and Cognitive Deficits Following Neonatal Seizures and Its Regulation by Chronic Leptin Treatment

(2018) Li-li Li et al.   Frontiers in Neurology

Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes

(2018) Eduard Peris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway

(2018) Zengjie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Cellular Mitochondrial Genome Landscape in Disease

(2018) Anne Hahn et al.   TRENDS IN CELL BIOLOGY

The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction

(2018) Felix Chan et al.   BRAIN

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

(2017) Geurt Stokman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway

(2017) Longsen Han et al.   JOURNAL OF PINEAL RESEARCH

The pathophysiological role of mitochondrial oxidative stress in lung diseases

(2017) Xiaojing Liu et al.   Journal of Translational Medicine

Anticonvulsant activity of resveratrol-loaded liposomes in vivo

(2017) M.S. Ethemoglu et al.   NEUROSCIENCE

Antioxidant polyphenols in cancer treatment: Friend, foe or foil?

(2017) Gian Luigi Russo et al.   SEMINARS IN CANCER BIOLOGY

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury

(2016) Aleksandra Kezic et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition

(2016) Manveen Bhardwaj et al.   Pharmacological Reports

Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type

(2016) Nickolay K. Isaev et al.   REVIEWS IN THE NEUROSCIENCES

Targeting Oxidative Stress in Central Nervous System Disorders

(2016) Manisha Patel   TRENDS IN PHARMACOLOGICAL SCIENCES

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

(2015) Eliska Holzerova et al.   BRAIN

Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review

(2015) M. Ramis et al.   CURRENT MEDICINAL CHEMISTRY

Hippocampal antioxidative system in mesial temporal lobe epilepsy

(2015) Aleksandar J. Ristić et al.   EPILEPSIA

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

(2015) Coen H. Wiegman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice

(2015) E. Santini et al.   JOURNAL OF NEUROSCIENCE

Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans

(2015) J. Gambini et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective Effect of Lycopene Against PTZ-induced Kindling Seizures in Mice: Possible Behavioural, Biochemical and Mitochondrial Dysfunction

(2015) Manveen Bhardwaj et al.   PHYTOTHERAPY RESEARCH

Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats

(2014) JUNLI ZHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Lycopene protects against apoptosis in hypoxia/reoxygenation-induced H9C2 myocardioblast cells through increased autophagy

(2014) FEI CHEN et al.   Molecular Medicine Reports

Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy

(2014) Harpreet Kaur et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

(2013) Kristina A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats

(2013) X. Qiu et al.   NEUROSCIENCE

Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins

(2013) Milena Atanasova et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model

(2012) Qun S. Zang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study

(2012) Lianne Schmaal et al.   NEUROPSYCHOPHARMACOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Effect of a mitochondria-targeted vitamin E derivative on mitochondrial alteration and systemic oxidative stress in mice

(2011) Gaowei Mao et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

(2011) Li-Ping Liang et al.   NEUROBIOLOGY OF DISEASE

Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats

(2010) Sukhdev S. Kamboj et al.   MITOCHONDRION

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

(2009) Jianfei Chao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mitochondrial DNA damage and impaired base excision repair during epileptogenesis

(2008) Stuart G. Jarrett et al.   NEUROBIOLOGY OF DISEASE

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING