Article
Neurosciences
Bianca R. Villa, Antis G. George, Timothy E. Shutt, Patrick G. Sullivan, Jong M. Rho, G. Campbell Teskey
Summary: Prolonged severe hypoxia following seizures is a mechanism for negative postictal manifestations. Arteriole vasoconstriction accounts for 50% of postictal hypoxia, but the remaining cause is unclear. Modulating mitochondrial function with drugs such as DNP can improve oxygen levels in the hippocampus and reduce postictal hypoxia. Antioxidants protect the brain from cognitive deficits associated with postictal hypoxia. These findings highlight the metabolic component of oxygen deprivation after seizures and suggest that mild mitochondrial uncoupling may be a potential therapeutic strategy.
Article
Neurosciences
Chiara Urbinati, Chiara Lanzillotta, Livia Cosentino, Daniela Valenti, Maria Cristina Quattrini, Livia Di Crescenzo, Francesca Prestia, Donatella Pietraforte, Marzia Perluigi, Fabio Di Domenico, Rosa Anna Vacca, Bianca De Filippis
Summary: Metformin treatment can selectively correct cognitive flexibility defects, improve mitochondrial function, and inhibit oxidative stress in female mice with Rett syndrome (RTT). However, it does not affect the general health and motor skills of RTT mice.
Article
Medicine, Research & Experimental
Zafer Yonden, Farzaneh Bonyadi, Yavar Yousefi, Amin Daemi, Seyyedeh Touran Hosseini, Sana Moshari
Summary: This study reveals that chronic and high-dose nano-micelle curcumin (NMC) can suppress the redox capacity and stimulate mitophagy signaling in the testicles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Timothy Fabisiak, Manisha Patel
Summary: Neuroinflammation and oxidative stress play important roles in the pathophysiology of epilepsy. They have significant crosstalk and influence each other through various mechanisms, affecting epileptic processes and disease outcomes. Treatment strategies targeting oxidative stress and redox regulation may help control neuroinflammation and improve patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Eliana Jardim Fernandes, Elize Aparecida Santos Musachio, Luana Barreto Meichtry, Dieniffer Espinosa Janner, Franciele Romero Machado Balok, Magna Sotelo Barrientos, Nathalie Savedra Gomes, Ketnne Hanna Poleto Pinto, Mustafa Munir Mustafa Dahleh, Andrieli Rodrigues, Sandra Elisa Haas, Silvana Peterini Boeira, Marina Prigol, Gustavo Petri Guerra
Summary: We investigated the potential toxic effects of chronic exposure to free curcumin and curcumin-loaded nanocapsules in Drosophila melanogaster, demonstrating the safe applications of nanoencapsulated curcumin.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Xue Wang, Chunyu Yang, Liu Yang, Yongbo Zhang
Summary: This study investigated the effect of modulating gut dysbiosis on epilepsy in rats and explored the potential molecular mechanisms involved.
FRONTIERS IN NUTRITION
(2022)
Article
Neurosciences
Iori Ohmori, Mamoru Ouchida, Hirohiko Imai, Saeko Ishida, Shinya Toyokuni, Tomoji Mashimo
Summary: Thioredoxin plays a critical role in reducing oxidative stress in the central nervous system (CNS). Mutations in the Txn1 gene were found to be associated with CNS degeneration and decreased insulin activity. Txn1 was shown to be involved in regulating oxidative stress in the midbrain with high energy metabolism, and neuronal death was observed in mutant rats.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Oncology
Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles Minard, Farook Jahoor, Rajagopal Sekhar
Summary: This study conducted a 36-week clinical trial in older adults, showing that GlyNAC supplementation for 24 weeks improved red-blood cell GSH deficiency, oxidative stress, and mitochondrial dysfunction in older adults. It also improved inflammation, endothelial dysfunction, insulin resistance, genomic damage, cognition, strength, gait-speed, exercise capacity, and lowered body fat and waist circumference. However, the benefits declined after stopping GlyNAC supplementation for 12 weeks.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Varvara A. Orekhova, Mirza S. Baig, Evgeny E. Bezsonov, Antonina Starodubova, Tatyana Popkova, Alexander N. Orekhov
Summary: Diabetes mellitus and related disorders are closely related to mitochondrial dysfunction. Specific types of mitochondrial diabetes, such as MIDD and DAD, have been identified. Mutations in mitochondrial DNA cause hereditary mitochondrial disorders, with tissue-specific phenotypes depending on the level of heteroplasmy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Sahithi Attaluri, Meenakshi Arora, Leelavathi N. Madhu, Maheedhar Kodali, Bing Shuai, Laila Melissari, Raghavendra Upadhya, Xiaolan Rao, Adrian Bates, Eeshika Mitra, Keyhan R. Ghahfarouki, M. N. Ravikumar, Ashok K. Shetty
Summary: This study found that low-dose, intermittent, oral polymer nanoparticle encapsulated curcumin (nCUR) therapy has potential for improving brain function in rats with chronic Gulf War Illness (GWI). nCUR treatment improved cognitive and mood function, reduced oxidative stress and neuroinflammation, and improved mitochondrial function and neurogenesis.
Review
Biochemistry & Molecular Biology
Jeong-Su Park, Nodir Rustamov, Yoon-Seok Roh
Summary: Chronic liver disease (CLD) is a global health issue that causes a significant number of deaths each year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (ALD) are two distinct forms of CLD, but they both share oxidative stress as a common pathology. Mitochondria, which are vital for liver metabolism, are compromised in diseases like NAFLD, ALD, and liver fibrosis due to inflammation, toxins, and metabolic irregularities. Nuclear factor erythroid 2-related factor 2 (NRF2) emerges as a cellular protector that regulates antioxidant genes and maintains mitochondrial health. The synergy between NRF2 modulation and mitochondrial function provides new therapeutic potentials for CLD by preserving mitochondrial integrity against oxidative threats.
Article
Agriculture, Multidisciplinary
Xin Li, Jiang Zhu, Qian Lin, Minjie Yu, Jianjun Lu, Jie Feng, Caihong Hu
Summary: This study found that curcumin has a protective effect, improving jejunal morphology and barrier function, enhancing mitochondrial function and ultrastructure, alleviating endoplasmic reticulum stress, and preventing excessive MAM formation and disorder.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Dinesh Kumar Chellappan, Keshav Raj Paudel, Nian Wan Tan, Ka Seng Cheong, Samantha Sert Qi Khoo, Su Min Seow, Jestin Chellian, Mayuren Candasamy, Vyoma K. Patel, Poonam Arora, Pankaj Kumar Singh, Sachin Kumar Singh, Gaurav Gupta, Brian G. Oliver, Philip M. Hansbro, Kamal Dua
Summary: Mitochondria play a crucial role in respiratory diseases, impacting airway morphology and epithelial function. Targeting dysfunctional mitochondria could be a promising treatment strategy for asthma, COPD, and lung cancer.
Article
Nutrition & Dietetics
Miyuki Kobara, Nessa Naseratun, Hiroe Toba, Tetsuo Nakata
Summary: The study found that preconditioning with short-term dietary restriction can attenuate chronic pressure overload-induced cardiac hypertrophy and associated oxidative stress, ultimately improving heart function.
Review
Biochemistry & Molecular Biology
Sahdeo Prasad, Dan DuBourdieu, Ajay Srivastava, Prafulla Kumar, Rajiv Lall
Summary: Curcumin, an active compound in turmeric, has various pharmacological properties, but its effectiveness is limited by its nature. Metal-curcumin complexes have been developed to enhance solubility and absorption, showing positive effects against chronic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Ishan Patro, Kulbhushan Tikoo, Rajat Sandhir
NEUROCHEMISTRY INTERNATIONAL
(2015)
Article
Behavioral Sciences
Surjeet Singh, Harpreet Kaur, Rajat Sandhir
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Gastroenterology & Hepatology
S. V. Rana, S. K. Sinha, S. Sharma, H. Kaur, D. K. Bhasin, K. Singh
DIGESTIVE DISEASES AND SCIENCES
(2009)
Article
Gastroenterology & Hepatology
S. V. Rana, S. Sharma, S. K. Sinha, H. Kaur, A. Sikander, K. Singh
DIGESTIVE DISEASES AND SCIENCES
(2009)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Shaveta Chauhan, Rajat Sandhir
NEUROCHEMICAL RESEARCH
(2011)
Article
Neurosciences
Harpreet Kaur, Svetlana Golovko, Mikhail Y. Golovko, Surjeet Singh, Diane C. Darland, Colin K. Combs
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Review
Biotechnology & Applied Microbiology
Harpreet Kaur, Yuvraj Singh, Surjeet Singh, Raja B. Singh
Summary: The gut-brain axis is a biochemical link connecting the central nervous system and enteric nervous system, with gut microbiota playing a key regulatory role and being associated with the pathogenesis of various neurological disorders.
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Drew Seeger, Svetlana Golovko, Mikhail Golovko, Colin Kelly Combs
Summary: Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive impairment, with studies suggesting the involvement of liver cholesterol and bile acid metabolism in its pathophysiology. Experimental results from two different AD mouse lines indicate fundamental deficiencies in liver cholesterol metabolism and bile acid synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Harpreet Kaur, Suba Nookala, Surjeet Singh, Santhosh Mukundan, Kumi Nagamoto-Combs, Colin Kelly Combs
Summary: The study found that only female App(NL-G-F) mice showed multiple beneficial changes in A beta plaques, microgliosis, brain TNF-alpha, and memory after probiotic treatment, while male mice had decreased A beta plaque load and colon cytokines with antibiotics treatment. Overall, probiotic treatment had positive effects in females, with minimal benefits of antibiotics or synbiotic feeding in male or female mice.
Review
Clinical Neurology
Mona Sohrabi, Bijayani Sahu, Harpreet Kaur, Wendie A. Hasler, Atish Prakash, Colin K. Combs
Summary: Studies have shown that Alzheimer's disease may not only affect the brain, but also the gastrointestinal tract, indicating a more systemic influence of the disease.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Geriatrics & Gerontology
Harpreet Kaur, Kumi Nagamoto-Combs, Svetlana Golovko, Mikhail Y. Golovko, Marilyn G. Klug, Colin Kelly Combs
NEUROBIOLOGY OF AGING
(2020)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)