The pathophysiological role of mitochondrial oxidative stress in lung diseases

IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response

(2016) Yi Jia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases

(2016) Li Yue et al.   BRITISH JOURNAL OF PHARMACOLOGY

Caudatin induces caspase-dependent apoptosis in human glioma cells with involvement of mitochondrial dysfunction and reactive oxygen species generation

(2016) Liang-zhen Zhu et al.   CELL BIOLOGY AND TOXICOLOGY

Expression of proteinase-activated receptor (PAR)-2 in monocytes from allergic patients and potential molecular mechanism

(2016) Shuqing Ge et al.   CELL BIOLOGY AND TOXICOLOGY

Differential effects of calcium on PI3K-Akt and HIF-1α survival pathways

(2016) Georgios Divolis et al.   CELL BIOLOGY AND TOXICOLOGY

Success of transdisciplinary science requires monodisciplinary support

(2016) Douglas S. Richardson   CELL BIOLOGY AND TOXICOLOGY

The effect of palmitate supplementation on gene expression profile in proliferating myoblasts

(2016) K. Grabiec et al.   CELL BIOLOGY AND TOXICOLOGY

Understanding toxicology: mechanisms and applications

(2016) Madhav Bhatia   CELL BIOLOGY AND TOXICOLOGY

Lutein protects against β-amyloid peptide-induced oxidative stress in cerebrovascular endothelial cells through modulation of Nrf-2 and NF-κb

(2016) Tao Liu et al.   CELL BIOLOGY AND TOXICOLOGY

New biomarkers and therapeutics can be discovered during COPD-lung cancer transition

(2016) Xiangdong Wang   CELL BIOLOGY AND TOXICOLOGY

Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation

(2016) Lianmin Bao et al.   CELL BIOLOGY AND TOXICOLOGY

Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer

(2016) Lianmin Bao et al.   CELL BIOLOGY AND TOXICOLOGY

Effect of memory CD4+ T cells’ signal transducer and activator of transcription (STATs) functional shift on cytokine-releasing properties in asthma

(2016) Zhihong Chen et al.   CELL BIOLOGY AND TOXICOLOGY

New future of cell biology and toxicology: thinking deeper

(2016) Jianying Gu et al.   CELL BIOLOGY AND TOXICOLOGY

Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia

(2016) Chengshui Chen et al.   CELL BIOLOGY AND TOXICOLOGY

Depolarization of mitochondrial membrane potential is the initial event in non-nucleoside reverse transcriptase inhibitor efavirenz induced cytotoxicity

(2016) Krishna Kumar Ganta et al.   CELL BIOLOGY AND TOXICOLOGY

Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation

(2016) Mahima Vedi et al.   CELL BIOLOGY AND TOXICOLOGY

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters

(2016) Lyle Wiemerslage et al.   JOURNAL OF NEUROSCIENCE METHODS

IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways

(2016) Xiaoqiong Su et al.   Journal of Translational Medicine

The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease

(2016) Adam Jerzy Białas et al.   Oxidative Medicine and Cellular Longevity

Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander?

(2016) David J. Rowlands   PHARMACOLOGY & THERAPEUTICS

Role of the Urokinase-Fibrinolytic System in Epithelial–Mesenchymal Transition during Lung Injury

(2015) Amarnath Satheesh Marudamuthu et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial quality control pathways as determinants of metabolic health

(2015) Ntsiki M. Held et al.   BIOESSAYS

Investigation of acetaminophen toxicity in HepG2/C3a microscale cultures using a system biology model of glutathione depletion

(2015) Eric Leclerc et al.   CELL BIOLOGY AND TOXICOLOGY

Effects of formaldehyde on mitochondrial dysfunction and apoptosis in SK-N-SH neuroblastoma cells

(2015) Tamanna Zerin et al.   CELL BIOLOGY AND TOXICOLOGY

The effects on health of ambient particles: time for an agonizing reappraisal?

(2015) Robert L. Maynard   CELL BIOLOGY AND TOXICOLOGY

The food supplement coenzyme Q10 and suppression of antitubercular drug-induced hepatic injury in rats: the role of antioxidant defence system, anti-inflammatory cytokine IL-10

(2015) Udhaya Lavinya Baskaran et al.   CELL BIOLOGY AND TOXICOLOGY

Oxidative damage induced by retching; antiemetic and neuroprotective role of Sambucus ebulus L.

(2015) Hamed Fathi et al.   CELL BIOLOGY AND TOXICOLOGY

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

(2015) Seok-Jo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vimentin regulates activation of the NLRP3 inflammasome

(2015) Gimena dos Santos et al.   Nature Communications

Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis

(2015) Avignat S. Patel et al.   PLoS One

Mitochondria in lung biology and pathology: more than just a powerhouse

(2014) Paul T. Schumacker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Photosensitized mefloquine induces ROS-mediated DNA damage and apoptosis in keratinocytes under ambient UVB and sunlight exposure

(2014) Neera Yadav et al.   CELL BIOLOGY AND TOXICOLOGY

Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites

(2014) Keyu Zhang et al.   CELL BIOLOGY AND TOXICOLOGY

Glycosaminoglycans can be associated with oxidative damage in mucopolysaccharidosis II patients submitted to enzyme replacement therapy

(2014) G. W. Negretto et al.   CELL BIOLOGY AND TOXICOLOGY

Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells

(2014) Jegan Athinarayanan et al.   CELL BIOLOGY AND TOXICOLOGY

Oxidative stress in pregnancy and fertility pathologies

(2014) Ana C. Pereira et al.   CELL BIOLOGY AND TOXICOLOGY

Structural mechanisms of inflammasome assembly

(2014) Alvin Lu et al.   FEBS Journal

Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions

(2014) M. C. Kenney et al.   HUMAN MOLECULAR GENETICS

Mitochondria-targeted Ogg1 and Aconitase-2 Prevent Oxidant-induced Mitochondrial DNA Damage in Alveolar Epithelial Cells

(2014) Seok-Jo Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy

(2014) Metodi Dimitrov Metodiev et al.   JOURNAL OF MEDICAL GENETICS

Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis

(2014) Amiq Gazdhar et al.   Scientific Reports

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact

(2014) Aswin Hari et al.   Scientific Reports

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Molecular Basis of Asbestos-Induced Lung Disease

(2013) Gang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages

(2013) Juciano Gasparotto et al.   CELL BIOLOGY AND TOXICOLOGY

DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways

(2013) Chung-Yu Chen et al.   CELL BIOLOGY AND TOXICOLOGY

Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells

(2013) Wen-xia Zhao et al.   CELL BIOLOGY AND TOXICOLOGY

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale

(2013) Sungwon Han et al.   CELL BIOLOGY AND TOXICOLOGY

PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells

(2013) Xiaobei Deng et al.   CELL BIOLOGY AND TOXICOLOGY

Pharmacological and Dietary Antioxidant Therapies for Chronic Obstructive Pulmonary Disease

(2013) S. Biswas et al.   CURRENT MEDICINAL CHEMISTRY

A mitochondrial bioenergetic etiology of disease

(2013) Douglas C. Wallace   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial matrix P53 sensitizes cells to oxidative stress

(2013) Christopher A. Koczor et al.   MITOCHONDRION

Oxidative stress and pulmonary fibrosis

(2012) Paul Cheresh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential effects of Bcl-2 and caspases on mitochondrial permeabilization during endogenous or exogenous reactive oxygen species-induced cell death

(2012) Vincent Rincheval et al.   CELL BIOLOGY AND TOXICOLOGY

Baicalein (5,6,7-trihydroxyflavone) reduces oxidative stress-induced DNA damage by upregulating the DNA repair system

(2012) Ki Cheon Kim et al.   CELL BIOLOGY AND TOXICOLOGY

The effect of oxidative stress upon the intestinal uptake of folic acid: in vitro studies with Caco-2 cells

(2012) Mafalda R. Couto et al.   CELL BIOLOGY AND TOXICOLOGY

Increased cerebral oxidative damage and decreased antioxidant defenses in ovariectomized and sham-operated rats supplemented with vitamin A

(2012) Guilherme Antonio Behr et al.   CELL BIOLOGY AND TOXICOLOGY

Reactive Oxygen Species, Inflammation, and Lung Diseases

(2012) Di Paola Rosanna et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs

(2011) Joshua M. Chouteau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Galectin-9 Attenuates Acute Lung Injury by Expanding CD14–Plasmacytoid Dendritic Cell–like Macrophages

(2011) Keisuke Kojima et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1

(2011) Andres A. Caro et al.   CELL BIOLOGY AND TOXICOLOGY

Selenium interactions and toxicity: a review

(2011) Iwona Zwolak et al.   CELL BIOLOGY AND TOXICOLOGY

Mitochondrial Rac1 GTPase Import and Electron Transfer from CytochromecAre Required for Pulmonary Fibrosis

(2011) Heather L. Osborn-Heaford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation

(2010) Barry R. Imhoff et al.   CELL BIOLOGY AND TOXICOLOGY

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis

(2010) Corrine R. Kliment et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rac1-mediated Mitochondrial H2O2Generation RegulatesMMP-9Gene Expression in Macrophages via Inhibition of SP-1 and AP-1

(2010) Shubha Murthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells

(2010) Ke-Hung Tsui et al.   PROSTATE

Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis

(2009) Shubha Murthy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Importance of oxidative stress in the pathogenesis and treatment of asthma

(2009) Marc A Riedl et al.   Current Opinion in Allergy and Clinical Immunology

Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis

(2009) V. Panduri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Superoxide dismutase 3, extracellular (SOD3) variants and lung function

(2009) Koustav Ganguly et al.   PHYSIOLOGICAL GENOMICS

Loss of Extracellular Superoxide Dismutase Leads to Acute Lung Damage in the Presence of Ambient Air

(2008) Maria Carolina Gongora et al.   AMERICAN JOURNAL OF PATHOLOGY

A Protein Kinase Cδ-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos

(2008) Sylke A. Buder-Hoffmann et al.   AMERICAN JOURNAL OF PATHOLOGY

Roflumilast: an oral, once-daily selective PDE-4 inhibitor for the management of COPD and asthma

(2008) Stephen K Field   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Impact of oxidative stress on lung diseases

(2008) Hee Sun PARK et al.   RESPIROLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE