Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway

Long-term melatonin treatment delays ovarian aging

(2017) Hiroshi Tamura et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse

(2017) Mianqun Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin regulates lipid metabolism in porcine oocytes

(2017) Jun-Xue Jin et al.   JOURNAL OF PINEAL RESEARCH

The role of mitochondrial sirtuins in health and disease

(2016) Brenna Osborne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment

(2016) Jih-Ing Chuang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors

(2016) Adrienne T. Perkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations

(2016) Jessica L. Saben et al.   Cell Reports

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes

(2015) Liang Zhang et al.   CELL CYCLE

Melatonin protects porcine oocyte in vitro maturation from heat stress

(2015) Yu Li et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

(2015) Long Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heartviathe SIRT1 signaling pathway

(2015) Dong Han et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces obesity and restores adipokine patterns and metabolism in obese ( ob/ob ) mice

(2015) Gaia Favero et al.   NUTRITION RESEARCH

Adverse effects of obesity and/or high-fat diet on oocyte quality and metabolism are not reversible with resumption of regular diet in mice

(2015) Kasey A. Reynolds et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Effect of a high fat diet on ovary morphology, in vitro development, in vitro fertilisation rate and oocyte quality in mice

(2015) M Sohrabi et al.   SINGAPORE MEDICAL JOURNAL

The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats

(2014) Kazime Gonca Akbulut et al.   BIOGERONTOLOGY

Melatonin and the circadian system: contributions to successful female reproduction

(2014) Russel J. Reiter et al.   FERTILITY AND STERILITY

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities

(2014) C. Leary et al.   HUMAN REPRODUCTION

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro1

(2013) Tessa Lord et al.   BIOLOGY OF REPRODUCTION

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peripheral Reproductive Organ Health and Melatonin: Ready for Prime Time

(2013) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality

(2012) Faten Shaeib et al.   FREE RADICAL BIOLOGY AND MEDICINE

The association between severe obesity and characteristics of failed fertilized oocytes

(2012) R. Machtinger et al.   HUMAN REPRODUCTION

Mechanistic insights into the regulation of metabolic enzymes by acetylation

(2012) Yue Xiong et al.   JOURNAL OF CELL BIOLOGY

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

High Fat Diet Induced Developmental Defects in the Mouse: Oocyte Meiotic Aneuploidy and Fetal Growth Retardation/Brain Defects

(2012) Kerri M. Luzzo et al.   PLoS One

Mitochondrial Metabolism, Sirtuins, and Aging

(2012) M. N. Sack et al.   Cold Spring Harbor Perspectives in Biology

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study

(2011) Barbara Luke et al.   FERTILITY AND STERILITY

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Diet-Induced Obesity Model: Abnormal Oocytes and Persistent Growth Abnormalities in the Offspring

(2010) Emily S. Jungheim et al.   ENDOCRINOLOGY

High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates

(2010) Linda Lin-Yan Wu et al.   ENDOCRINOLOGY

Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

(2010) Yumiko Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions

(2010) U. Eichenlaub-Ritter et al.   MITOCHONDRION

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes

(2009) Mei-Jie Jou et al.   JOURNAL OF PINEAL RESEARCH

Maternal Diabetes Causes Mitochondrial Dysfunction and Meiotic Defects in Murine Oocytes

(2009) Qiang Wang et al.   MOLECULAR ENDOCRINOLOGY

Mitochondrial function and redox state in mammalian embryos

(2009) R. Dumollard et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Reverses the Adverse Effects of Diet-Induced Obesity on Oocyte Quality

(2008) Cadence E. Minge et al.   ENDOCRINOLOGY

The melatonin metaboliteN1-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger

(2008) Meike Schaefer et al.   JOURNAL OF PINEAL RESEARCH

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

(2007) Hiroshi Tamura et al.   JOURNAL OF PINEAL RESEARCH