Bottom-up de novo design of functional proteins with complex structural features
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Title
Bottom-up de novo design of functional proteins with complex structural features
Authors
Keywords
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Journal
Nature Chemical Biology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-05
DOI
10.1038/s41589-020-00699-x
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- (2019) Michelle C. Crank et al. SCIENCE
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- (2019) Marco Santorelli et al. CURRENT OPINION IN BIOTECHNOLOGY
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- Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins
- (2018) Jarrod J. Mousa et al. PLoS Pathogens
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- (2018) Horst Lechner et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- De novo design of a fluorescence-activating β-barrel
- (2018) Jiayi Dou et al. NATURE
- Rosetta FunFolDes – A general framework for the computational design of functional proteins
- (2018) Jaume Bonet et al. PLoS Computational Biology
- Massively parallel de novo protein design for targeted therapeutics
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- (2017) Enrique Marcos et al. SCIENCE
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- (2016) Remco Arts et al. ANALYTICAL CHEMISTRY
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- (2016) J.M. de la Rosa-Trevín et al. JOURNAL OF STRUCTURAL BIOLOGY
- Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV
- (2016) Ivy Widjaja et al. JOURNAL OF VIROLOGY
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- (2016) Antony J. Burton et al. Nature Chemistry
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- (2016) Stephanie Berger et al. eLife
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Exploring the repeat protein universe through computational protein design
- (2015) TJ Brunette et al. NATURE
- Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera
- (2015) Joan O. Ngwuta et al. Science Translational Medicine
- CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies
- (2014) C. W. Wood et al. BIOINFORMATICS
- A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
- (2014) Erik Procko et al. CELL
- Proof of principle for epitope-focused vaccine design
- (2014) Bruno E. Correia et al. NATURE
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- (2014) Nathan H. Joh et al. SCIENCE
- Computational design of water-soluble α-helical barrels
- (2014) Andrew R. Thomson et al. SCIENCE
- Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
- (2013) J. S. McLellan et al. SCIENCE
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Principles for designing ideal protein structures
- (2012) Nobuyasu Koga et al. NATURE
- Characterizing the complexity of enzymes on the basis of their mechanisms and structures with a bio-computational analysis
- (2011) Gemma L. Holliday et al. FEBS Journal
- RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design
- (2011) Po-Ssu Huang et al. PLoS One
- Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
- (2011) M. L. Azoitei et al. SCIENCE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F
- (2010) J. S. McLellan et al. JOURNAL OF VIROLOGY
- Structural basis of respiratory syncytial virus neutralization by motavizumab
- (2010) Jason S McLellan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
- (2010) Bruno E. Correia et al. STRUCTURE
- Computational characterization of B-cell epitopes
- (2007) Nimrod D. Rubinstein et al. MOLECULAR IMMUNOLOGY
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