Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Structure-based immunogen design — leading the way to the new age of precision vaccines

(2018) Fabian Sesterhenn et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation

(2018) Eileen Goodwin et al.   IMMUNITY

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

motifStack for the analysis of transcription factor binding site evolution

(2018) Jianhong Ou et al.   NATURE METHODS

Synthetic Standards Combined With Error and Bias Correction Improve the Accuracy and Quantitative Resolution of Antibody Repertoire Sequencing in Human Naïve and Memory B Cells

(2018) Simon Friedensohn et al.   Frontiers in Immunology

Rosetta FunFolDes – A general framework for the computational design of functional proteins

(2018) Jaume Bonet et al.   PLoS Computational Biology

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine

(2017) Pierre-Louis Hervé et al.   Nanomedicine-Nanotechnology Biology and Medicine

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody

(2017) Donald D. Raymond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for antibody-mediated neutralization of Lassa virus

(2017) Kathryn M. Hastie et al.   SCIENCE

Antibody-dependent enhancement of severe dengue disease in humans

(2017) Leah C. Katzelnick et al.   SCIENCE

Advanced Methodologies in High-Throughput Sequencing of Immune Repertoires

(2017) Simon Friedensohn et al.   TRENDS IN BIOTECHNOLOGY

What Are the Most Powerful Immunogen Design Vaccine Strategies?

(2017) Dennis R. Burton   Cold Spring Harbor Perspectives in Biology

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

(2017) Daniel W. Kulp et al.   Nature Communications

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein

(2017) Noushin Jaberolansar et al.   Scientific Reports

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

(2017) Murillo Silva et al.   Cell Reports

Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection

(2017) Kristien Van Reeth et al.   npj Vaccines

A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus

(2017) Meihui Xu et al.   npj Vaccines

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

(2016) Dennis R. Burton et al.   Annual Review of Immunology

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

(2016) Bryan Briney et al.   CELL

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

(2016) Rino Rappuoli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV

(2016) Ivy Widjaja et al.   JOURNAL OF VIROLOGY

Structural basis of potent Zika–dengue virus antibody cross-neutralization

(2016) Giovanna Barba-Spaeth et al.   NATURE

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

(2016) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

(2016) M Gordon Joyce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

(2016) Z. A. Bornholdt et al.   SCIENCE

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

(2016) M Gordon Joyce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Accurate and predictive antibody repertoire profiling by molecular amplification fingerprinting

(2016) T. A. Khan et al.   Science Advances

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus

(2016) Jeffrey C. Boyington et al.   PLoS One

Germinal Center Selection and the Antibody Response to Influenza

(2015) Gabriel D. Victora et al.   CELL

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Sequential Infection in Ferrets with Antigenically Distinct Seasonal H1N1 Influenza Viruses Boosts Hemagglutinin Stalk-Specific Antibodies

(2015) Greg A. Kirchenbaum et al.   JOURNAL OF VIROLOGY

High Preexisting Serological Antibody Levels Correlate with Diversification of the Influenza Vaccine Response

(2015) Sarah F. Andrews et al.   JOURNAL OF VIROLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza

(2015) Veronika I. Zarnitsyna et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein

(2015) Jason S McLellan   Current Opinion in Virology

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

Visualizing the replication of respiratory syncytial virus in cells and in living mice

(2014) Marie-Anne Rameix-Welti et al.   Nature Communications

Immune history shapes specificity of pandemic H1N1 influenza antibody responses

(2013) Yang Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

(2011) Jason S. McLellan et al.   JOURNAL OF MOLECULAR BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design

(2010) Bruno E. Correia et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of respiratory syncytial virus neutralization by motavizumab

(2010) Jason S McLellan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elicitation of structure-specific antibodies by epitope scaffolds

(2010) G. Ofek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

(2010) Bruno E. Correia et al.   STRUCTURE

Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus

(2009) R. G. Tawar et al.   SCIENCE

Sub-Nucleocapsid Nanoparticles: A Nasal Vaccine against Respiratory Syncytial Virus

(2008) Xavier Roux et al.   PLoS One