De novo design of bioactive protein switches

Modular and tunable biological feedback control using a de novo protein switch

(2019) Andrew H. Ng et al.   NATURE

De novo design of a fluorescence-activating β-barrel

(2018) Jiayi Dou et al.   NATURE

Rational design of proteins that exchange on functional timescales

(2017) James A Davey et al.   Nature Chemical Biology

Global analysis of protein folding using massively parallel design, synthesis, and testing

(2017) Gabriel J. Rocklin et al.   SCIENCE

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

(2016) S. E. Boyken et al.   SCIENCE

Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast

(2016) Andrés Aranda-Díaz et al.   ACS Synthetic Biology

Allostery: An Overview of Its History, Concepts, Methods, and Applications

(2016) Jin Liu et al.   PLoS Computational Biology

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

(2016) Stephanie Berger et al.   eLife

Exploring the repeat protein universe through computational protein design

(2015) TJ Brunette et al.   NATURE

Synthetic protein switches: design principles and applications

(2015) Viktor Stein et al.   TRENDS IN BIOTECHNOLOGY

Design of protein switches based on an ensemble model of allostery

(2015) Jay H. Choi et al.   Nature Communications

A Highly Characterized Yeast Toolkit for Modular, Multipart Assembly

(2015) Michael E. Lee et al.   ACS Synthetic Biology

De novo design of a transmembrane Zn2+-transporting four-helix bundle

(2014) Nathan H. Joh et al.   SCIENCE

High thermodynamic stability of parametrically designed helical bundles

(2014) Po-Ssu Huang et al.   SCIENCE

Engineering allostery

(2014) Srivatsan Raman et al.   TRENDS IN GENETICS

The enabled state of DNA nanotechnology

(2013) Veikko Linko et al.   CURRENT OPINION IN BIOTECHNOLOGY

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

(2012) Ahmad S. Khalil et al.   CELL

Protein Conformational Switches: From Nature to Design

(2012) Jeung-Hoi Ha et al.   CHEMISTRY-A EUROPEAN JOURNAL

Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators

(2012) Alexander Wittmann et al.   FEBS LETTERS

Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins

(2012) Laura Delgado-Soler et al.   Journal of Chemical Information and Modeling

Molecular biology of Bax and Bak activation and action

(2010) Dana Westphal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Probing Designability via a Generalized Model of Helical Bundle Geometry

(2010) Gevorg Grigoryan et al.   JOURNAL OF MOLECULAR BIOLOGY

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

(2010) Thomas Güttler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient Protein-Protein Interactions: Structural, Functional, and Network Properties

(2010) James R. Perkins et al.   STRUCTURE

Control of DNA Strand Displacement Kinetics Using Toehold Exchange

(2009) David Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase

(2008) Junko Takeuchi et al.   BIOCHEMICAL JOURNAL

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY