Installing hydrolytic activity into a completely de novo protein framework

De novo protein design: how do we expand into the universe of possible protein structures?

(2015) Derek N Woolfson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

New Tricks for Old Proteins: Single Mutations in a Nonenzymatic Protein Give Rise to Various Enzymatic Activities

(2015) Yurii S. Moroz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies

(2014) C. W. Wood et al.   BIOINFORMATICS

Design of activated serine–containing catalytic triads with atomic-level accuracy

(2014) Sridharan Rajagopalan et al.   Nature Chemical Biology

Short peptides self-assemble to produce catalytic amyloids

(2014) Caroline M. Rufo et al.   Nature Chemistry

Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase

(2014) N. Preiswerk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A designed supramolecular protein assembly with in vivo enzymatic activity

(2014) Woon Ju Song et al.   SCIENCE

Computational design of water-soluble α-helical barrels

(2014) Andrew R. Thomson et al.   SCIENCE

High thermodynamic stability of parametrically designed helical bundles

(2014) Po-Ssu Huang et al.   SCIENCE

Computational Enzyme Design

(2013) Gert Kiss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of Protein Catalysts

(2013) Donald Hilvert   Annual Review of Biochemistry

Designing functional metalloproteins: From structural to catalytic metal sites

(2013) Melissa L. Zastrow et al.   COORDINATION CHEMISTRY REVIEWS

De novo enzymes by computational design

(2013) Hajo Kries et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly

(2013) Antony J. Burton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precision is essential for efficient catalysis in an evolved Kemp eliminase

(2013) Rebecca Blomberg et al.   NATURE

Evolution of a designed retro-aldolase leads to complete active site remodeling

(2013) Lars Giger et al.   Nature Chemical Biology

Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering

(2012) Bryan S. Der et al.   BIOCHEMISTRY

New currency for old rope: from coiled-coil assemblies to α-helical barrels

(2012) Derek N Woolfson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Constructing manmade enzymes for oxygen activation

(2012) Craig T. Armstrong et al.   DALTON TRANSACTIONS

Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis

(2012) Florian Richter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology

(2012) Jordan M. Fletcher et al.   ACS Synthetic Biology

A de novo peptide hexamer with a mutable channel

(2011) Nathan R Zaccai et al.   Nature Chemical Biology

Hydrolytic catalysis and structural stabilization in a designed metalloprotein

(2011) Melissa L. Zastrow et al.   Nature Chemistry

De Novo Enzyme Design Using Rosetta3

(2011) Florian Richter et al.   PLoS One

An exciting but challenging road ahead for computational enzyme design

(2010) David Baker   PROTEIN SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

Designing artificial enzymes by intuition and computation

(2009) Vikas Nanda et al.   Nature Chemistry

PoreWalker: A Novel Tool for the Identification and Characterization of Channels in Transmembrane Proteins from Their Three-Dimensional Structure

(2009) Marialuisa Pellegrini-Calace et al.   PLoS Computational Biology

Structural Reorganization and Preorganization in Enzyme Active Sites: Comparisons of Experimental and Theoretically Ideal Active Site Geometries in the Multistep Serine Esterase Reaction Cycle

(2008) Adam J. T. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE