Mitophagy Impairment in Neurodegenerative Diseases: Pathogenesis and Therapeutic Interventions
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mitophagy Impairment in Neurodegenerative Diseases: Pathogenesis and Therapeutic Interventions
Authors
Keywords
Neurodegenerative diseases, Mitophagy, Mitochondria, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington diseases
Journal
MITOCHONDRION
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-01-19
DOI
10.1016/j.mito.2021.01.001
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Exaggerated mitophagy: a weapon of striatal destruction in the brain?
- (2020) Srinivasa Subramaniam BIOCHEMICAL SOCIETY TRANSACTIONS
- ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
- (2020) Natalia Moskal et al. Nature Communications
- ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs
- (2020) Yueh-Lin Tsai et al. GENES & DEVELOPMENT
- Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
- (2020) Clara Berenguer-Escuder et al. HUMAN MOLECULAR GENETICS
- Coordinated action of miR-146a and Parkin gene regulate Rotenone-induced neurodegeneration
- (2020) Abhishek Jauhari et al. TOXICOLOGICAL SCIENCES
- Downregulation of miR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis
- (2020) Noemi De Luna et al. Scientific Reports
- Mdm2 enhances ligase activity of parkin and facilitates mitophagy
- (2020) Seunghyi Kook et al. Scientific Reports
- Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective
- (2020) Manohar Kodavati et al. Cells
- Mitochondrial turnover and homeostasis in ageing and neurodegeneration
- (2020) Maria Markaki et al. FEBS LETTERS
- Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases
- (2020) Xu Yan et al. Frontiers in Cellular Neuroscience
- Altered mitochondrial dynamics and function in APOE4-expressing astrocytes
- (2020) Eran Schmukler et al. Cell Death & Disease
- Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges
- (2020) Rong Yu et al. Frontiers in Endocrinology
- Early Mitochondrial Fragmentation and Dysfunction in a Drosophila Model for Alzheimer’s Disease
- (2020) Xingjun Wang et al. MOLECULAR NEUROBIOLOGY
- Resveratrol ameliorates disorders of mitochondrial biogenesis and mitophagy in rats continuously exposed to benzo(a)pyrene from embryonic development through adolescence
- (2020) Kai-Ge Chen et al. TOXICOLOGY
- LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease
- (2019) Fiona Bonello et al. HUMAN MOLECULAR GENETICS
- Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
- (2019) Evandro F. Fang et al. NATURE NEUROSCIENCE
- Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1
- (2019) Shiori Sekine et al. MOLECULAR CELL
- PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells
- (2019) Chia-Yuan Lin et al. FOOD AND CHEMICAL TOXICOLOGY
- PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All
- (2019) Alejandro Lloret et al. NEUROCHEMICAL RESEARCH
- TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
- (2019) Peng Wang et al. PLoS Genetics
- Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer’s Disease
- (2019) Patricia Martín-Maestro et al. JOURNAL OF ALZHEIMERS DISEASE
- Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells
- (2019) Patricia Martín-Maestro et al. MOLECULAR NEUROBIOLOGY
- Reversible induction of mitophagy by an optogenetic bimodular system
- (2019) Pasquale D’Acunzo et al. Nature Communications
- Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
- (2019) Ricardo Aparicio et al. Cell Reports
- Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment
- (2019) Jia Liu et al. Cells
- Neuroprotective effects of memantine via enhancement of autophagy
- (2019) Kazuoki Hirano et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo
- (2019) Shira Simonovitch et al. JOURNAL OF ALZHEIMERS DISEASE
- NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
- (2019) Evandro F. Fang et al. Nature Communications
- FKBP8 LIRL‐dependent mitochondrial fragmentation facilitates mitophagy under stress conditions
- (2019) Seung‐Min Yoo et al. FASEB JOURNAL
- Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice
- (2019) Sachiko Noda et al. NEUROBIOLOGY OF DISEASE
- Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death
- (2019) Mitchell L. De Snoo et al. Cell Death & Disease
- The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
- (2019) Caroline Kumsta et al. Nature Communications
- Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment
- (2019) Massimiliano Castellazzi et al. Scientific Reports
- IMAGING MITOPHAGY IN THE FRUIT FLY
- (2018) Wim Vandenberghe et al. Autophagy
- Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
- (2018) Thomas Briston et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy
- (2018) Arthur F. Kluge et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease
- (2018) P Hemachandra Reddy et al. HUMAN MOLECULAR GENETICS
- Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease
- (2018) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- The multifaceted contributions of mitochondria to cellular metabolism
- (2018) Jessica B. Spinelli et al. NATURE CELL BIOLOGY
- Building and decoding ubiquitin chains for mitophagy
- (2018) J. Wade Harper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
- (2018) Stephani A. Davis et al. NEUROSCIENCE LETTERS
- ROCK inhibition in models of neurodegeneration and its potential for clinical translation
- (2018) Jan Christoph Koch et al. PHARMACOLOGY & THERAPEUTICS
- Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death
- (2018) Maria A. Gonzalez Porras et al. PHYSIOLOGY
- NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- (2018) Yujun Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease
- (2018) Hui Wang et al. TOXICOLOGY LETTERS
- AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
- (2018) Anthea Di Rita et al. Frontiers in Cellular Neuroscience
- Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
- (2018) Tom Cornelissen et al. eLife
- The Therapeutic Potential of Metformin in Neurodegenerative Diseases
- (2018) Carola Rotermund et al. Frontiers in Endocrinology
- Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy
- (2018) Zhihao Wu et al. EXPERIMENTAL GERONTOLOGY
- Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes
- (2018) Bernadette Schreiner et al. JOURNAL OF ALZHEIMERS DISEASE
- Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
- (2018) Konstantinos Palikaras et al. NATURE CELL BIOLOGY
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
- (2018) Claudio Soto et al. NATURE NEUROSCIENCE
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
- (2018) Barry Boland et al. NATURE REVIEWS DRUG DISCOVERY
- FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models
- (2018) Jianwen Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor
- (2018) Zhao-Tao Wang et al. AGING CELL
- Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria
- (2018) Nadia Cummins et al. EMBO JOURNAL
- Miro proteins prime mitochondria for Parkin translocation and mitophagy
- (2018) Dzhamilja Safiulina et al. EMBO JOURNAL
- mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons
- (2017) Han-Kyu Lee et al. JOURNAL OF ALZHEIMERS DISEASE
- Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
- (2017) Vincenzo Sorrentino et al. NATURE
- Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease
- (2017) Adam L. Orr et al. NEUROCHEMISTRY INTERNATIONAL
- Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture
- (2017) Thomas Misgeld et al. NEURON
- The role of mitochondria in amyotrophic lateral sclerosis
- (2017) Emma F. Smith et al. NEUROSCIENCE LETTERS
- Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
- (2017) Elodie Villa et al. Cell Reports
- Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
- (2017) Anna-Elisa Roser et al. Frontiers in Aging Neuroscience
- Edaravone and its clinical development for amyotrophic lateral sclerosis
- (2017) Koji Takei et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice
- (2017) Robert S. Rogers et al. Frontiers in Neuroscience
- Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
- (2017) Sayad Kocahan et al. Clinical Psychopharmacology and Neuroscience
- Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
- (2017) Brianada Koentjoro et al. Scientific Reports
- Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins
- (2017) Vladimir V. Rogov et al. Scientific Reports
- Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
- (2016) Ming Chen et al. Autophagy
- NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy
- (2016) V E Kagan et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges
- (2016) Aiwu Cheng et al. Cell Metabolism
- Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
- (2016) Chung-Han Hsieh et al. Cell Stem Cell
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Protein aggregation and neurodegenerative diseases: From theory to therapy
- (2016) Vijay Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Role of mitochondrial dysfunction in cancer progression
- (2016) Chia-Chi Hsu et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway
- (2016) Raymonde Szargel et al. HUMAN MOLECULAR GENETICS
- Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection
- (2016) Daniel A. East et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance
- (2016) Ming Lu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
- (2016) Erica Barini et al. Molecular Neurodegeneration
- Autophagy maintains stemness by preventing senescence
- (2016) Laura García-Prat et al. NATURE
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
- (2016) Dongryeol Ryu et al. NATURE MEDICINE
- The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
- (2016) Wenzhang Wang et al. NATURE MEDICINE
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
- (2016) Benjamin Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis
- (2016) Ji Heun Jeong et al. Experimental and Therapeutic Medicine
- VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
- (2016) Xing Guo et al. Nature Communications
- An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models
- (2016) Archana Prasad et al. Scientific Reports
- HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within?
- (2015) Yan-Ning Rui et al. Autophagy
- Reticulophagy and nucleophagy: New findings and unsolved issues
- (2015) Hitoshi Nakatogawa et al. Autophagy
- Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria
- (2015) Yvette C Wong et al. Autophagy
- BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32
- (2015) Kinya Otsu et al. Autophagy
- Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy
- (2015) Cathrin Meissner et al. Autophagy
- The role of mitochondrial dysfunction in age-related diseases
- (2015) Rebecca K. Lane et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Loss of mitochondrial transmembrane potential and glutathione depletion are not sufficient to account for induction of apoptosis by carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone in human leukemia K562 cells
- (2015) Petr Mlejnek et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease
- (2015) S. Hwang et al. EMBO Molecular Medicine
- NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
- (2015) V. Corsetti et al. HUMAN MOLECULAR GENETICS
- PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
- (2015) Patricia Martín-Maestro et al. HUMAN MOLECULAR GENETICS
- The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling
- (2015) Divya Pathak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy receptor defects and ALS-FTLD
- (2015) Veronika Majcher et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Measuring In Vivo Mitophagy
- (2015) Nuo Sun et al. MOLECULAR CELL
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
- (2015) Jin-Mi Heo et al. MOLECULAR CELL
- Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt
- (2015) Amrita M. Nargund et al. MOLECULAR CELL
- Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
- (2015) Konstantinos Palikaras et al. NATURE
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
- (2015) Christian N. Cunningham et al. NATURE CELL BIOLOGY
- Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
- (2015) Wenzhang Wang et al. NATURE MEDICINE
- Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?
- (2015) Seyedeh Maryam Alavi Naini et al. Oxidative Medicine and Cellular Longevity
- Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
- (2015) Uma A. Mukherjee et al. PHARMACOLOGY & THERAPEUTICS
- STEP61is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
- (2015) Pradeep K. Kurup et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease
- (2015) B Khalil et al. Cell Death & Disease
- Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
- (2015) Tomokazu Murakawa et al. Nature Communications
- Altered macroautophagy in the spinal cord of SOD1 mutant mice
- (2014) Liang Li et al. Autophagy
- Autophagy is required for extension of yeast chronological life span by rapamycin
- (2014) Ashley L. Alvers et al. Autophagy
- LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons
- (2014) Charleen T Chu et al. Autophagy
- BECN1 is involved in the initiation of mitophagy
- (2014) Vinay Choubey et al. Autophagy
- mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits
- (2014) Fengying Yang et al. BEHAVIOURAL BRAIN RESEARCH
- Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration
- (2014) Krysti Todd et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
- (2014) F Strappazzon et al. CELL DEATH AND DIFFERENTIATION
- Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation
- (2014) Dirk Mossmann et al. Cell Metabolism
- Fasting: Molecular Mechanisms and Clinical Applications
- (2014) Valter D. Longo et al. Cell Metabolism
- A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
- (2014) Wen Yue et al. CELL RESEARCH
- Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP
- (2014) Camilla T. Ambivero et al. CELLULAR SIGNALLING
- PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy
- (2014) Daniel A. East et al. CHEMISTRY & BIOLOGY
- PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions
- (2014) Conggang Zhang et al. CURRENT BIOLOGY
- Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
- (2014) Konstantinos Palikaras et al. EXPERIMENTAL GERONTOLOGY
- The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
- (2014) Y. C. Wong et al. JOURNAL OF NEUROSCIENCE
- A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy
- (2014) Guo Chen et al. MOLECULAR CELL
- The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
- (2014) Baris Bingol et al. NATURE
- Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease
- (2014) Bindu D. Paul et al. NATURE
- Involvement of oxidative stress in SAMP10 mice with age-related neurodegeneration
- (2014) Jun Wang et al. NEUROLOGICAL SCIENCES
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
- (2014) V. A. Morais et al. SCIENCE
- Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation
- (2014) B I Pérez-Revuelta et al. Cell Death & Disease
- Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin
- (2014) Thomas R. Caulfield et al. PLoS Computational Biology
- Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease
- (2014) Jana Hroudová et al. Biomed Research International
- Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity
- (2014) Sijun Yang et al. Redox Biology
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- PINK1 is degraded through the N-end rule pathway
- (2013) Koji Yamano et al. Autophagy
- Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines
- (2013) Joel A. Cassel et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
- (2013) Nicholas T. Hertz et al. CELL
- Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast
- (2013) Akinori Eiyama et al. FEBS LETTERS
- How Parkinsonian Toxins Dysregulate the Autophagy Machinery
- (2013) Ruben Dagda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Phosphorylation by Protein Kinase Cδ (PKCδ) Inhibits Mitochondria Elimination by Lysosomal-like Structures following Ischemia and Reoxygenation-induced Injury
- (2013) Gouri Yogalingam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model
- (2013) Hong Xie et al. JOURNAL OF NEUROSCIENCE
- Regulation of mitophagy by the Gp78 E3 ubiquitin ligase
- (2013) Min Fu et al. MOLECULAR BIOLOGY OF THE CELL
- Genetics of amyotrophic lateral sclerosis: an update
- (2013) Sheng Chen et al. Molecular Neurodegeneration
- Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
- (2013) Charleen T. Chu et al. NATURE CELL BIOLOGY
- Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
- (2013) A. Rana et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
- (2013) J.-F. Trempe et al. SCIENCE
- Spatiotemporally controlled induction of autophagy-mediated lysosome turnover
- (2013) Yu-Hsien Hung et al. Nature Communications
- Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
- (2013) Atsushi Hoshino et al. Nature Communications
- Neuropathological Alterations in Alzheimer Disease
- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
- Trafficking and Proteolytic Processing of APP
- (2013) C. Haass et al. Cold Spring Harbor Perspectives in Medicine
- Parkin Disease
- (2013) Karen M. Doherty et al. JAMA Neurology
- The genetics and neuropathology of Parkinson’s disease
- (2012) Henry Houlden et al. ACTA NEUROPATHOLOGICA
- Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation
- (2012) Mauricio Budini et al. BRAIN RESEARCH
- The pathways of mitophagy for quality control and clearance of mitochondria
- (2012) G Ashrafi et al. CELL DEATH AND DIFFERENTIATION
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
- (2012) Carles Cantó et al. Cell Metabolism
- Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions
- (2012) Masashi Kitazawa et al. CURRENT PHARMACEUTICAL DESIGN
- Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
- (2012) Michael Lazarou et al. DEVELOPMENTAL CELL
- G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
- (2012) Tatiana D. Papkovskaia et al. HUMAN MOLECULAR GENETICS
- Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis
- (2012) Yanyan Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy
- (2012) Rita A. Hanna et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A New Link to Mitochondrial Impairment in Tauopathies
- (2012) Kathrin L. Schulz et al. MOLECULAR NEUROBIOLOGY
- α-Synuclein and Neuronal Cell Death
- (2012) Toru Yasuda et al. MOLECULAR NEUROBIOLOGY
- Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
- (2012) Lei Liu et al. NATURE CELL BIOLOGY
- Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
- (2012) Dong Liu et al. NEUROBIOLOGY OF AGING
- Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease
- (2012) C. Venkateshappa et al. NEUROCHEMICAL RESEARCH
- Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line
- (2012) Kun Hong et al. NEUROSCIENCE LETTERS
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
- (2012) Song Liu et al. PLoS Genetics
- Cerebral amyloid angiopathy in the elderly
- (2011) Anand Viswanathan et al. ANNALS OF NEUROLOGY
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
- (2011) Flavie Strappazzon et al. EMBO JOURNAL
- Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
- (2011) M. J. Calkins et al. HUMAN MOLECULAR GENETICS
- Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
- (2011) U. Shirendeb et al. HUMAN MOLECULAR GENETICS
- Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
- (2011) Vinay Choubey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
- (2011) Cathrin Meissner et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis
- (2011) Shoichi Sasaki JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Parkin Interacts with Ambra1 to Induce Mitophagy
- (2011) C. Van Humbeeck et al. JOURNAL OF NEUROSCIENCE
- Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
- (2011) Wenjun Song et al. NATURE MEDICINE
- PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease
- (2011) Ming-Chang Chiang et al. NEUROBIOLOGY OF DISEASE
- 2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease
- (2011) Jia Yao et al. PLoS One
- Mitochondria and Neuroplasticity
- (2010) Aiwu Cheng et al. ASN Neuro
- Short-term fasting induces profound neuronal autophagy
- (2010) Mehrdad Alirezaei et al. Autophagy
- Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage
- (2010) Shiu-Hwa Yeh et al. BRAIN PATHOLOGY
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Mitochondrial Dynamics in Alzheimerʼs Disease
- (2010) David J. Bonda et al. DRUGS & AGING
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
- (2010) C. Rose et al. HUMAN MOLECULAR GENETICS
- The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
- (2010) Virginie Loeb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration
- (2010) Tomohiro Nakamura et al. MITOCHONDRION
- The molecular mechanism of mitochondria autophagy in yeast
- (2010) Tomotake Kanki et al. MOLECULAR MICROBIOLOGY
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- (2010) Sven Geisler et al. NATURE CELL BIOLOGY
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease
- (2010) Tyisha Hathorn et al. NEUROBIOLOGY OF DISEASE
- ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import
- (2010) Q. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
- (2010) M. M. Lipinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)
- (2010) J Sassone et al. Cell Death & Disease
- Coenzyme Q10 effects in neurodegenerative disease
- (2010) Claire Henchcliffe Neuropsychiatric Disease and Treatment
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases
- (2009) Gary E. Gibson et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondria in Huntington's disease
- (2009) Maria Damiano et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
- (2009) Hyunkyung Jeong et al. CELL
- Role of BNIP3 and NIX in cell death, autophagy and mitophagy
- (2009) J Zhang et al. CELL DEATH AND DIFFERENTIATION
- Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
- (2009) Koji Okamoto et al. DEVELOPMENTAL CELL
- Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
- (2009) Vanessa A. Morais et al. EMBO Molecular Medicine
- MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission
- (2009) Emélie Braschi et al. EMBO REPORTS
- Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease
- (2009) Jiro Fukae et al. FEBS LETTERS
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- (2009) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Optical Reporters for the Conformation of -Synuclein Reveal a Specific Interaction with Mitochondria
- (2008) K. Nakamura et al. JOURNAL OF NEUROSCIENCE
- PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
- (2008) Alison Wood-Kaczmar et al. PLoS One
- The amyloid -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
- (2008) C. A. Hansson Petersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started