The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

Dual targeting of mitochondrial proteins: Mechanism, regulation and function

(2010) Ohad Yogev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural determinants of PINK1 topology and dual subcellular distribution

(2010) William Lin et al.   BMC CELL BIOLOGY

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Intramembrane Proteolysis of Mgm1 by the Mitochondrial Rhomboid Protease Is Highly Promiscuous Regarding the Sequence of the Cleaved Hydrophobic Segment

(2010) Anja Schäfer et al.   JOURNAL OF MOLECULAR BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The PARL family of mitochondrial rhomboid proteases

(2010) R. Blake Hill et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

Intramembrane Proteolysis

(2009) Michael S. Wolfe   CHEMICAL REVIEWS

PINK1 function in health and disease

(2009) Emma Deas et al.   EMBO Molecular Medicine

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

Genomic and proteomic biomarkers for Parkinson disease

(2009) T. Gasser   NEUROLOGY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhomboid Proteases and their Biological Functions

(2008) Matthew Freeman   Annual Review of Genetics

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

(2008) A. J. Whitworth et al.   Disease Models & Mechanisms

The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway

(2008) Birthe Meineke et al.   FEBS LETTERS

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

(2008) Ryan D. Mills et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

(2008) Jyh-Rong Chao et al.   NATURE

The kinase domain of mitochondrial PINK1 faces the cytoplasm

(2008) C. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA