Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

(2013) Fabia Febbraro et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein phosphorylation as a therapeutic target in Parkinson’s disease

(2012) Steven P. Braithwaite et al.   REVIEWS IN THE NEUROSCIENCES

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Establishment of a Database of Metformin Plasma Concentrations and Erythrocyte Levels in Normal and Emergency Situations

(2011) Jean-Daniel Lalau et al.   CLINICAL DRUG INVESTIGATION

Enhanced Phosphatase Activity Attenuates  -Synucleinopathy in a Mouse Model

(2011) K.-W. Lee et al.   JOURNAL OF NEUROSCIENCE

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

Control of mTORC1 signaling by the Opitz syndrome protein MID1

(2011) E. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

(2010) Preeti J Khandelwal et al.   Molecular Neurodegeneration

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

(2009) G. Ahlin et al.   DRUG METABOLISM AND DISPOSITION

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin

(2009) Regan M. Memmott et al.   JOURNAL OF CLINICAL ONCOLOGY

Organic Cation Transporters and their Pharmacokinetic and Pharmacodynamic Consequences

(2008) Min-Koo Choi et al.   Drug Metabolism and Pharmacokinetics