Steps in metastasis: an updated review

Cancer Genome Evolutionary Trajectories in Metastasis

(2020) Nicolai J. Birkbak et al.   CANCER CELL

VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling

(2020) Zhuan Zhou et al.   CANCER LETTERS

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

(2020) Timothy Marsh et al.   DEVELOPMENTAL CELL

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

(2020) Ryan T. Davis et al.   NATURE CELL BIOLOGY

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

(2020) Marco Montagner et al.   NATURE CELL BIOLOGY

Zinc finger protein 367 promotes metastasis by inhibiting the Hippo pathway in breast cancer

(2020) Xianqiu Wu et al.   ONCOGENE

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

(2020) Bo He et al.   Cell Reports

Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX

(2020) Eudmar Marcolino et al.   Oncogenesis

Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis

(2020) Cheng-Liang Kuo et al.   CANCER LETTERS

Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

(2020) Katie L Owen et al.   EMBO REPORTS

Tumour‐derived exosomal miR‐3473b promotes lung tumour cell intrapulmonary colonization by activating the nuclear factor‐κB of local fibroblasts

(2020) Cancan Du et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis

(2020) Keywan Mortezaee   LIFE SCIENCES

Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib

(2020) Gianluigi Giannelli et al.   PLoS One

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

(2020) Lin Zhang et al.   Science Translational Medicine

Glypican-3 (GPC3) inhibits metastasis development promoting dormancy in breast cancer cells by p38 MAPK pathway activation

(2020) Macarena Guereño et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

­­The transcriptional repressor BCL11A promotes breast cancer metastasis

(2020) Darcie D. Seachrist et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth

(2020) Ruo-Yu Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Navigating the path to distant metastasis

(2020) Trevor A. Graham et al.   NATURE GENETICS

TGFβ biology in cancer progression and immunotherapy

(2020) Rik Derynck et al.   Nature Reviews Clinical Oncology

IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion

(2020) Rakhee Bajaj et al.   ONCOGENE

Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis

(2020) Chun-Jung Ko et al.   ONCOGENE

CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK

(2020) Binyan Lin et al.   ONCOGENE

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

(2020) Erin N. Howe et al.   Nature Communications

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

(2020) Kenji Fujiyoshi et al.   EBioMedicine

ERK1/2 signaling induces upregulation of ANGPT2 and CXCR4 to mediate liver metastasis in colon cancer

(2020) Jelena Urosevic et al.   CANCER RESEARCH

Immune escape: A critical hallmark in solid tumors

(2020) Keywan Mortezaee   LIFE SCIENCES

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

(2020) Cinzia Donato et al.   Cell Reports

Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model

(2020) W. F. Hynes et al.   Science Advances

Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment.

(2019) Claudia Tulotta et al.   CLINICAL CANCER RESEARCH

Phase I dose-escalation study of chiauranib, a novel angiogenic, mitotic, and chronic inflammation inhibitor, in patients with advanced solid tumors

(2019) Yongkun Sun et al.   Journal of Hematology & Oncology

Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis

(2019) Karla C. Williams et al.   ONCOGENE

Brain metastases

(2019) Achal Singh Achrol et al.   Nature Reviews Disease Primers

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

(2019) Stefanie Hendrikx et al.   Cell Reports

Neutrophil Degranulation, Plasticity, and Cancer Metastasis

(2019) Faustino Mollinedo   TRENDS IN IMMUNOLOGY

NF‐κB targeting for overcoming tumor resistance and normal tissues toxicity

(2019) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A novel ACKR2-dependent role of fibroblast-derived CXCL14 in epithelial-to-mesenchymal transition and metastasis of breast cancer

(2019) Elin Sjöberg et al.   CLINICAL CANCER RESEARCH

TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer

(2019) Davide Melisi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural mesothelioma in the IFCT-GFPC-0701 MAPS Phase 3 trial

(2019) Elodie Maille et al.   BRITISH JOURNAL OF CANCER

Phase I Study of Emactuzumab Single Agent or in Combination with Paclitaxel in Patients with Advanced/Metastatic Solid Tumors Reveals Depletion of Immunosuppressive M2-like Macrophages

(2019) C A Gomez-Roca et al.   ANNALS OF ONCOLOGY

Wnt/PCP Signaling Contribution to Carcinoma Collective Cell Migration and Metastasis

(2019) Kacey VanderVorst et al.   CANCER RESEARCH

Extracellular‐signal‐regulated kinase (ERK)/mitogen‐activated protein kinase (MAPK) signaling as a target for cancer therapy: An updated review

(2019) Masoud Najafi et al.   CELL BIOLOGY INTERNATIONAL

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clinicopathological significance and prognostic role of chemokine receptor CXCR4 expression in pancreatic ductal adenocarcinoma, a meta-analysis and literature review

(2019) Yong Ding et al.   International Journal of Surgery

Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer

(2019) Thomas B. Karasic et al.   JAMA Oncology

The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection

(2019) Lauritz Miarka et al.   Cancers

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

(2019) Wenjing Su et al.   CANCER CELL

Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review

(2019) Keywan Mortezaee et al.   LIFE SCIENCES

Tenascin-C increases lung metastasis by impacting blood vessel invasions

(2019) Zhen Sun et al.   MATRIX BIOLOGY

EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis

(2019) Lechen Li et al.   ONCOGENE

Neutrophil Diversity in Health and Disease

(2019) Carlos Silvestre-Roig et al.   TRENDS IN IMMUNOLOGY

A Phase 2 Study of Galunisertib (TGF-β1 Receptor Type I Inhibitor) and Sorafenib in Patients With Advanced Hepatocellular Carcinoma

(2019) R.K. Kelley et al.   Clinical and Translational Gastroenterology

Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma

(2019) Reena P Thomas et al.   CLINICAL CANCER RESEARCH

Cancer stem cell (a)symmetry & plasticity: Tumorigenesis and therapy relevance

(2019) Masoud Najafi et al.   LIFE SCIENCES

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins

(2019) Cédric Zeltz et al.   SEMINARS IN CANCER BIOLOGY

Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest

(2019) Naël Osmani et al.   Cell Reports

Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis

(2019) Lu Tong et al.   CELL DEATH AND DIFFERENTIATION

Redox interactions and genotoxicity of metal-based nanoparticles: A comprehensive review

(2019) Keywan Mortezaee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

(2019) Keywan Mortezaee et al.   CURRENT CANCER DRUG TARGETS

Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance

(2019) Masoud Najafi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cancer stem cell (CSC) resistance drivers

(2019) Masoud Najafi et al.   LIFE SCIENCES

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

(2019) Gonçalo Rodrigues et al.   NATURE CELL BIOLOGY

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

(2019) Sijia Liu et al.   CLINICAL CANCER RESEARCH

Hypoxia induces core-to-edge transition of progressive tumoral cells: A critical review on differential yet corroborative roles for HIF-1α and HIF-2α

(2019) Keywan Mortezaee   LIFE SCIENCES

Boosting immune system against cancer by melatonin: A mechanistic viewpoint

(2019) Keywan Mortezaee et al.   LIFE SCIENCES

Stromal reprogramming: A target for tumor therapy

(2019) Masoud Najafi et al.   LIFE SCIENCES

A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis

(2019) Jacob P. Hoj et al.   Cell Reports

A Phase II Study of Celecoxib With Irinotecan, 5-Fluorouracil, and Leucovorin in Patients With Previously Untreated Advanced or Metastatic Colorectal Cancer

(2018) Emerson Y. Chen et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

(2018) Nobuaki Takahashi et al.   CANCER CELL

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review

(2018) Keywan Mortezaee   CELL BIOCHEMISTRY AND FUNCTION

Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study

(2018) Manish A. Shah et al.   CLINICAL CANCER RESEARCH

Human hepatocellular carcinoma: Protection by melatonin

(2018) Keywan Mortezaee   JOURNAL OF CELLULAR PHYSIOLOGY

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

(2018) Vasiliki Gkretsi et al.   Frontiers in Oncology

Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization

(2018) B. Farhood et al.   Clinical & Translational Oncology

Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer

(2018) Jinlin Cai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Disruption of the redox balance with either oxidative or anti-oxidative overloading as a promising target for cancer therapy

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cancer-associated fibroblasts: Secretions, interactions, and therapy

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adjuvant chemotherapy with melatonin for targeting human cancers: A review

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization

(2018) Zafira Castaño et al.   NATURE CELL BIOLOGY

Dynamic changes of different phenotypic and genetic circulating tumor cells as a biomarker for evaluating the prognosis of RCC

(2018) Zhen-Long Wang et al.   CANCER BIOLOGY & THERAPY

Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming

(2018) Custodia García-Jiménez et al.   Cell Metabolism

Curcumin as an anti-inflammatory agent: Implications to radiotherapy and chemotherapy

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A framework for the development of effective anti-metastatic agents

(2018) Robin L. Anderson et al.   Nature Reviews Clinical Oncology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

NSD2 is a conserved driver of metastatic prostate cancer progression

(2018) Alvaro Aytes et al.   Nature Communications

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells

(2018) Simone Bersini et al.   Oncotarget

NADPH oxidase as a target for modulation of radiation response; implications to carcinogenesis and radiotherapy

(2018) Keywan Mortezaee et al.   Current Molecular Pharmacology

Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition

(2017) Wei Li et al.   International Journal of Nanomedicine

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

The role of exosomes in cancer metastasis

(2017) Teresa Bernadette Steinbichler et al.   SEMINARS IN CANCER BIOLOGY

Senescent tumor cells lead the collective invasion in thyroid cancer

(2017) Young Hwa Kim et al.   Nature Communications

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study

(2017) Ryan J. Sullivan et al.   Cancer Discovery

High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study

(2017) Kishore Polireddy et al.   Scientific Reports

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

(2016) Sonam Dhamija et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma

(2016) Takaaki Higashi et al.   MEDICAL ONCOLOGY

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis

(2014) Mihoko Sutoh Yoneyama et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer

(2014) Jordi Rodón et al.   INVESTIGATIONAL NEW DRUGS

The expression of hypoxia-inducible factor-1α and its clinical significance in lung cancer: a systematic review and meta-analysis

(2014) W Ren et al.   SWISS MEDICAL WEEKLY

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

Antiangiogenic therapy, hypoxia and metastasis: risky liaisons, or not?

(2011) Katrien De Bock et al.   Nature Reviews Clinical Oncology

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Weekly topotecan as second- or third-line treatment in patients with recurrent or metastatic cervical cancer

(2008) Jaime Coronel et al.   MEDICAL ONCOLOGY