Adjuvant chemotherapy with melatonin for targeting human cancers: A review

Human hepatocellular carcinoma: Protection by melatonin

(2018) Keywan Mortezaee   JOURNAL OF CELLULAR PHYSIOLOGY

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

(2018) Ying-Qiang Shen et al.   JOURNAL OF PINEAL RESEARCH

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

(2018) Chi Kwan Tsang et al.   MOLECULAR CELL

To Claim Growth Turf, mTOR Says SOD Off

(2018) Hyewon Kong et al.   MOLECULAR CELL

Complex Formation of Resorufin and Resazurin with Β-Cyclodextrins: Can Cyclodextrins Interfere with a Resazurin Cell Viability Assay?

(2018) Rita Csepregi et al.   MOLECULES

Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore

(2018) Saranya NavaneethaKrishnan et al.   ONCOGENE

Stimuli-responsive nanotherapeutics for precision drug delivery and cancer therapy

(2018) Yiting Qiao et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The Impact of Melatonin on Colon Cancer Cells’ Resistance to Doxorubicin in an in Vitro Study

(2017) Magdalena Fic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin application in targeting oxidative-induced liver injuries: A review

(2017) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy

(2017) Néstor Prieto-Domínguez et al.   Oncotarget

Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy

(2016) Shengpeng Wang et al.   JOURNAL OF CONTROLLED RELEASE

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

(2016) Néstor Prieto-Domínguez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways

(2016) Yue Gao et al.   JOURNAL OF PINEAL RESEARCH

Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action

(2016) SURIYAN PONNUSAMY et al.   ONCOLOGY REPORTS

Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

(2016) Yun-Xin Lu et al.   Cell Death & Disease

The mechanism of acacetin-induced apoptosis on oral squamous cell carcinoma

(2015) Chae-Doo Kim et al.   ARCHIVES OF ORAL BIOLOGY

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

(2015) P. Plaimee et al.   CELL PROLIFERATION

Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase

(2015) Miho Yamanishi et al.   EXPERIMENTAL HEMATOLOGY

Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane

(2015) Ornella Fantappiè et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation

(2015) Huai-Qiang Ju et al.   JOURNAL OF PINEAL RESEARCH

Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

(2015) Roberto Pariente et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells

(2015) Jian-Jun Lu et al.   Oncotarget

Melatonin Sensitizes H1975 Non-Small-Cell Lung Cancer Cells Harboring a T790M-Targeted Epidermal Growth Factor Receptor Mutation to the Tyrosine Kinase Inhibitor Gefitinib

(2014) Miyong Yun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

(2014) Canhui Yi et al.   PLoS One

Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing Survivin

(2013) Lulu Fan et al.   JOURNAL OF PINEAL RESEARCH

Endoplasmic Reticulum Stress–Induced Resistance to Doxorubicin Is Reversed by Paeonol Treatment in Human Hepatocellular Carcinoma Cells

(2013) Lulu Fan et al.   PLoS One

The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials

(2012) Ye-min Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The modulatory effect of melatonin on genotoxicity of irinotecan in healthy human lymphocytes and cancer cells

(2012) Renata Kontek et al.   DRUG AND CHEMICAL TOXICOLOGY

Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: Molecular basis for the anticancer effect of these molecules

(2012) Martina Margheri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin enhances thapsigargin-induced apoptosis through reactive oxygen species-mediated upregulation of CCAAT-enhancer-binding protein homologous protein in human renal cancer cells

(2012) Kyoung-jin Min et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction

(2012) Naree Song et al.   JOURNAL OF PINEAL RESEARCH

Phenotypic changes caused by melatonin increased sensitivity of prostate cancer cells to cytokine-induced apoptosis

(2012) Aida Rodriguez-Garcia et al.   JOURNAL OF PINEAL RESEARCH

Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways

(2012) Jingshu Wang et al.   JOURNAL OF PINEAL RESEARCH

TRP channels: diagnostic markers and therapeutic targets for breast cancer?

(2012) Halima Ouadid-Ahidouch et al.   TRENDS IN MOLECULAR MEDICINE

Melatonin sensitizes Caki renal cancer cells to kahweol-induced apoptosis through CHOP-mediated up-regulation of PUMA

(2011) Hee Jung Um et al.   JOURNAL OF PINEAL RESEARCH

Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer

(2011) Chun W. Tam et al.   JOURNAL OF PINEAL RESEARCH

Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells

(2011) Ji-Hyun Kim et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5′-adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells

(2011) Wonil Koh et al.   JOURNAL OF PINEAL RESEARCH

Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis

(2011) Lixia Zha et al.   JOURNAL OF PINEAL RESEARCH

Hsp27 Promotes Insulin-Like Growth Factor-I Survival Signaling in Prostate Cancer via p90Rsk-Dependent Phosphorylation and Inactivation of BAD

(2010) A. Zoubeidi et al.   CANCER RESEARCH

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

(2010) Giuseppe Paradies et al.   JOURNAL OF PINEAL RESEARCH

Protective effect of melatonin on oxaliplatin-induced apoptosis through sustained Mcl-1 expression and anti-oxidant action in renal carcinoma Caki cells

(2010) Hee Jung Um et al.   JOURNAL OF PINEAL RESEARCH

Notch Signaling Pathway as a Therapeutic Target in Breast Cancer

(2010) H. Al-Hussaini et al.   MOLECULAR CANCER THERAPEUTICS

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

(2009) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

Combination of melatonin and a peroxisome proliferator-activated receptor-γ agonist induces apoptosis in a breast cancer cell line

(2008) Ahmet Korkmaz et al.   JOURNAL OF PINEAL RESEARCH