Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

(2018) Maria Kalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

(2018) Maria Kalli et al.   Frontiers in Oncology

Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA)

(2017) Vasiliki Gkretsi et al.   EXPERIMENTAL CELL RESEARCH

The Solid Mechanics of Cancer and Strategies for Improved Therapy

(2017) Triantafyllos Stylianopoulos   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

(2017) Fotios Mpekris et al.   JOURNAL OF CONTROLLED RELEASE

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach

(2017) Vasiliki Gkretsi et al.   Oncotarget

Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications

(2017) Xiao-Xiang Jie et al.   Oncotarget

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

(2017) Christiana Polydorou et al.   Oncotarget

Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview

(2017) Do Kim et al.   Journal of Clinical Medicine

Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner

(2017) Panagiotis Papageorgis et al.   Scientific Reports

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome

(2016) Edward R. Horton et al.   EXPERIMENTAL CELL RESEARCH

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

The predictive link between matrix and metastasis

(2016) LE Barney et al.   Current Opinion in Chemical Engineering

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples

(2015) Nikolina Giotopoulou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Remodeling of extracellular matrix due to solid stress accumulation during tumor growth

(2015) Athanassios P. Pirentis et al.   CONNECTIVE TISSUE RESEARCH

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Role of TGFβ in regulation of the tumor microenvironment and drug delivery (Review)

(2015) PANAGIOTIS PAPAGEORGIS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis

(2015) Hideki Ueno et al.   VIRCHOWS ARCHIV

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

(2015) Priscilla S. Briquez et al.   Advances in Wound Care

Remodeling Components of the Tumor Microenvironment to Enhance Cancer Therapy

(2015) Vasiliki Gkretsi et al.   Frontiers in Oncology

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

The landscape of metastatic progression patterns across major human cancers

(2015) Jan Budczies et al.   Oncotarget

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate

(2014) Matthew G. Rubashkin et al.   CANCER RESEARCH

Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis

(2014) H.-Y. Jung et al.   CLINICAL CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Role of Constitutive Behavior and Tumor-Host Mechanical Interactions in the State of Stress and Growth of Solid Tumors

(2014) Chrysovalantis Voutouri et al.   PLoS One

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

E-cadherin-integrin crosstalk in cancer invasion and metastasis

(2013) M. Canel et al.   JOURNAL OF CELL SCIENCE

Mechanical Stress Impairs Mitosis Progression in Multi-Cellular Tumor Spheroids

(2013) Annaïck Desmaison et al.   PLoS One

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Expression and clinical significance of FAK, ILK, and PTEN in salivary adenoid cystic carcinoma

(2012) Dong Chen et al.   ACTA OTO-LARYNGOLOGICA

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Overexpression of integrin-linked kinase (ILK) is associated with tumor progression and an unfavorable prognosis in patients with colorectal cancer

(2012) Rui Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Erik Sahai: Getting the whole picture of metastasis

(2011) Caitlin Sedwick   JOURNAL OF CELL BIOLOGY

Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma

(2011) Hong-Xing Cai   Molecular Medicine Reports

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Expression Profiles in 3D Tumor Analogs Indicate Compressive Strain Differentially Enhances Metastatic Potential

(2010) Zoe N. Demou   ANNALS OF BIOMEDICAL ENGINEERING

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

The dual kinase complex FAK-Src as a promising therapeutic target in cancer

(2010) Victoria Bolós   OncoTargets and Therapy

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms

(2009) Samuel Schmidt et al.   CELL AND TISSUE RESEARCH

How ILK and kindlins cooperate to orchestrate integrin signaling

(2009) Ralph T Böttcher et al.   CURRENT OPINION IN CELL BIOLOGY

Migfilin Interacts with Src and Contributes to Cell-Matrix Adhesion-mediated Survival Signaling

(2009) Jianping Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

(2009) John A. Pedersen et al.   JOURNAL OF BIOMECHANICS

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

Focal adhesion kinase (FAK) expression in normal and neoplastic lymphoid tissues

(2009) Sermin Ozkal et al.   PATHOLOGY RESEARCH AND PRACTICE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Expression of integrin-linked kinase and its binding partners in chondrosarcoma: Association with prognostic significance

(2008) Dionysios J. Papachristou et al.   EUROPEAN JOURNAL OF CANCER