Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review

Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis

(2018) Xiaoyu Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice

(2018) Min Li et al.   FASEB JOURNAL

NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis

(2018) Silvia Svegliati et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of methyltrienolone (R1881) in AKTs and AR expression patterns of cultured granulosa-lutein cells

(2018) Saeid Nekoonam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammasome: Its role in traumatic brain and spinal cord injury

(2018) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human hepatocellular carcinoma: Protection by melatonin

(2018) Keywan Mortezaee   JOURNAL OF CELLULAR PHYSIOLOGY

To Claim Growth Turf, mTOR Says SOD Off

(2018) Hyewon Kong et al.   MOLECULAR CELL

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB

(2018) Simona Camorani et al.   Oncotarget

Aucubin and its hydrolytic derivative attenuate activation of hepatic stellate cells via modulation of TGF-β stimulation

(2017) Pei-Yu Lv et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats

(2017) Razieh Kabirifar et al.   Hepatobiliary & Pancreatic Diseases International

Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats

(2017) Jianlin He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

(2017) Zhongwei Cao et al.   Science Translational Medicine

Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice

(2017) Dalia M. El-Tanbouly et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ursolic acid suppresses TGF-β1-induced quiescent HSC activation and transformation by inhibiting NADPH oxidase expression and Hedgehog signaling

(2017) Shan-Shan Yu et al.   Experimental and Therapeutic Medicine

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

(2017) So Yeon Kim et al.   Nature Communications

Sex-determining region Y-box 9 acts downstream of NADPH oxidase to influence the effect of leptin on PPARγ1 expression in hepatic stellate cells

(2016) Haowen Qiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic value of melatonin post-treatment on CCl4-induced fibrotic rat liver

(2016) Keywan Mortezaee et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

(2016) Haitao Shi et al.   CLINICAL NUTRITION

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

(2016) Elena Arriazu et al.   GUT

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

(2016) Duy-Khanh Dang et al.   Journal of Neuroinflammation

Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells

(2016) Yue Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

(2016) Shuang Liang et al.   Frontiers in Physiology

Salidroside alleviates oxidative stress in the liver with non- alcoholic steatohepatitis in rats

(2016) Ze-ran Yang et al.   BMC Pharmacology & Toxicology

Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells

(2016) Soo-Mi Kweon et al.   PLoS One

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

(2015) Diptadip Dattaroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cross-Talk Between TGF-β and NADPH Oxidases During Liver Fibrosis and Hepatocarcinogenesis

(2015) Eva Crosas-Molist et al.   CURRENT PHARMACEUTICAL DESIGN

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

(2015) Ahmed Bettaieb et al.   GASTROENTEROLOGY

The human Nox4: gene, structure, physiological function and pathological significance

(2015) Shuhui Guo et al.   JOURNAL OF DRUG TARGETING

Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models

(2015) Ze Zheng et al.   JOURNAL OF HEPATOLOGY

Effect of human recombinant granulocyte colony-stimulating factor on rat busulfan-induced testis injury

(2015) Neda Khanlarkhani et al.   JOURNAL OF MOLECULAR HISTOLOGY

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

(2015) Kai Y Mak et al.   MOLECULAR THERAPY

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis

(2014) Yan-yan Tao et al.   BMC Complementary and Alternative Medicine

Polyunsaturated fatty acids balance affects platelet NOX2 activity in patients with liver cirrhosis

(2014) Stefania Basili et al.   DIGESTIVE AND LIVER DISEASE

Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: Role of NADPH oxidase

(2014) Mi Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma

(2014) Jinah Choi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression

(2014) Eva Crosas-Molist et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro

(2014) Young Ji Choi et al.   LIFE SCIENCES

Simultaneous quantification and validation of new peroxynitrite scavengers fromArtemisia iwayomogi

(2014) Agung Nugroho et al.   PHARMACEUTICAL BIOLOGY

Lipid Metabolism, Oxidative Stress and Cell Death Are Regulated by PKC Delta in a Dietary Model of Nonalcoholic Steatohepatitis

(2014) Michael W. Greene et al.   PLoS One

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Role of NADPH Oxidases in Liver Fibrosis

(2013) Yong-Han Paik et al.   ANTIOXIDANTS & REDOX SIGNALING

Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis

(2013) Gang Zhao et al.   GUT

Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr−/− Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis

(2013) Christopher M. Depner et al.   JOURNAL OF NUTRITION

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

(2012) David E. Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation

(2012) Jong-Min Han et al.   FOOD AND CHEMICAL TOXICOLOGY

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor

(2012) Ching-Fen Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Large hepatitis delta antigen activates STAT-3 and NF-κB via oxidative stress

(2012) V. Williams et al.   JOURNAL OF VIRAL HEPATITIS

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

(2012) Radina Kostadinova et al.   Cell and Bioscience

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

(2011) Wenhao Cui et al.   HEPATOLOGY

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation

(2011) Xinjuan Pan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Angiotensin II increases mRNA levels of all TGF-β isoforms in quiescent and activated rat hepatic stellate cells

(2010) Paola Moreno-Alvarez et al.   CELL BIOLOGY INTERNATIONAL

Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis In Vivo

(2010) Joy X. Jiang et al.   GASTROENTEROLOGY

Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis

(2010) Samuele De Minicis et al.   HEPATOLOGY

Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells

(2010) Erica Novo et al.   JOURNAL OF HEPATOLOGY

NOX/NADPH Oxidase, the Superoxide-Generating Enzyme: Its Transcriptional Regulation and Physiological Roles

(2010) Masato Katsuyama   JOURNAL OF PHARMACOLOGICAL SCIENCES

Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice

(2010) Subhadip Ghatak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

(2009) Jordi Colmenero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

(2009) Joy X. Jiang et al.   JOURNAL OF HEPATOLOGY

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress

(2009) Wataru Okiyama et al.   JOURNAL OF HEPATOLOGY

Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells

(2009) Eduardo L.M. Guimarães et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor  -Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

(2009) H. E. Boudreau et al.   JOURNAL OF VIROLOGY

Regulation of cell proliferation by NADPH oxidase-mediated signaling: Potential roles in tissue repair, regenerative medicine and tissue engineering

(2009) Elsa C. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats

(2009) Ming-Kuei Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects

(2008) Seiichiro Kurita et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tissue Inhibitor of Metalloproteinase 3 Deficiency Causes Hepatic Steatosis and Adipose Tissue Inflammation in Mice

(2008) Rossella Menghini et al.   GASTROENTEROLOGY

Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells

(2008) Samuele De Minicis et al.   HEPATOLOGY

Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis

(2008) Nidal Muhanna et al.   HEPATOLOGY

Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor α, reduced glutathione, and transforming growth factor β-dependent mechanisms

(2008) Francisco Javier Cubero et al.   HEPATOLOGY

Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration

(2008) Ghazaleh Aram et al.   HEPATOLOGY

Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism

(2008) Joy X. Jiang et al.   HEPATOLOGY

Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide

(2008) Adam C. Straub et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative stress in alcoholic liver disease: Role of NADPH oxidase complex

(2008) Samuele De Minicis et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Apocynin: Molecular Aptitudes

(2008) J. Stefanska et al.   MEDIATORS OF INFLAMMATION

Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells

(2008) Mark F. McCarty et al.   MEDICAL HYPOTHESES