Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease

(2019) Huan Liu et al.   Science Translational Medicine

The Mononuclear Phagocytic System. Generation of Diversity

(2019) Siamon Gordon et al.   Frontiers in Immunology

CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma

(2019) Ruyi Xu et al.   Cell Death & Disease

The Osteoclast in Bone Metastasis: Player and Target

(2018) Antonio Maurizi et al.   Cancers

Diverse Functions of Macrophages in Different Tumor Microenvironments

(2018) Ming Yang et al.   CANCER RESEARCH

IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

(2018) Sahil Gupta et al.   OncoImmunology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

(2017) Lena Batoon et al.   BIOMATERIALS

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies

(2016) Daniela F. Quail et al.   CLINICAL CANCER RESEARCH

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Working with Commercially Available Quantum Dots for Immunofluorescence on Tissue Sections

(2016) Sandrine Prost et al.   PLoS One

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

(2016) Trevor T. Price et al.   Science Translational Medicine

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

IL4 Receptor ILR4  Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways

(2014) K. T. Venmar et al.   CANCER RESEARCH

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Paradoxical Roles of IL-4 in Tumor Immunity

(2010) Zhiguang Li et al.   Cellular & Molecular Immunology

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors

(2009) Laureen S. Ojalvo et al.   AMERICAN JOURNAL OF PATHOLOGY

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion

(2009) A. Varin et al.   BLOOD

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE