Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX

The Platelet Lifeline to Cancer: Challenges and Opportunities

(2018) Monika Haemmerle et al.   CANCER CELL

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth

(2017) R M Kershaw et al.   Oncogenesis

CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation

(2017) Y H Siddiqui et al.   Oncogenesis

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

(2016) MengJie Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synergistic immunologic targets for the treatment of prostate cancer

(2016) Karen M Doersch et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal

(2016) Monika Haemmerle et al.   JOURNAL OF CLINICAL INVESTIGATION

Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion

(2016) Kevin Gaston et al.   Cell and Bioscience

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Inflammation and prostate cancer: the role of interleukin 6 (IL-6)

(2013) Daniel P. Nguyen et al.   BJU INTERNATIONAL

Comment on “Platelet-Derived Nucleotides Promote Tumor Cell Transendothelial Migration and Metastasis via P2Y2 Receptor” by Schumacher et al.

(2013) Matthew T. Harper et al.   CANCER CELL

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin

(2013) R M Kershaw et al.   ONCOGENE

Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival

(2012) Peter Noy et al.   NUCLEIC ACIDS RESEARCH

TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation

(2012) Jonas Fuxe et al.   SEMINARS IN CANCER BIOLOGY

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

A potential role for the homeoprotein Hhex in hepatocellular carcinoma progression

(2011) Juan Su et al.   MEDICAL ONCOLOGY

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

(2010) L. Erpenbeck et al.   BLOOD

Protein Kinase Cθ Negatively Regulates Store-independent Ca2+Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets

(2010) Matthew T. Harper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRH/Hhex Controls Cell Survival through Coordinate Transcriptional Regulation of Vascular Endothelial Growth Factor Signaling

(2010) P. Noy et al.   MOLECULAR AND CELLULAR BIOLOGY

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding

(2009) Abdenour Soufi et al.   NUCLEIC ACIDS RESEARCH

PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate

(2008) Abdenour Soufi et al.   BIOCHEMICAL JOURNAL