Mucosal immunity and tRNA, tRF, and tiRNA

Innate Lymphoid Cells in Colorectal Cancers: A Double-Edged Sword

(2020) Qiutong Huang et al.   Frontiers in Immunology

A novel, mitochondrial, internal tRNA-derived RNA fragment possesses clinical utility as a molecular prognostic biomarker in chronic lymphocytic leukemia

(2020) Paraskevi Karousi et al.   CLINICAL BIOCHEMISTRY

The Role of Mucosal Immunity in Pertussis

(2019) Luis Solans et al.   Frontiers in Immunology

Innate lymphoid cells in intestinal cancer development

(2019) Imke Atreya et al.   SEMINARS IN IMMUNOLOGY

Angiogenin promotes colorectal cancer metastasis via tiRNA production

(2019) Siqi Li et al.   INTERNATIONAL JOURNAL OF CANCER

Using tRNA halves as novel biomarkers for the diagnosis of gastric cancer

(2019) Linwen Zhu et al.   Cancer Biomarkers

Identification of a novel tRNA‐derived RNA fragment exhibiting high prognostic potential in chronic lymphocytic leukemia

(2019) Paraskevi Karousi et al.   HEMATOLOGICAL ONCOLOGY

tRNA-derived fragments and tRNA halves: The new players in cancers

(2019) Linwen Zhu et al.   CANCER LETTERS

Deciphering the Roles of Innate Lymphoid Cells in Cancer

(2019) Melanie Bruchard et al.   Frontiers in Immunology

tRNA-Derived Small Non-Coding RNAs as Novel Epigenetic Molecules Regulating Adipogenesis

(2019) Linyuan Shen et al.   Biomolecules

tRNA-derived fragment tRF-03357 promotes cell proliferation, migration and invasion in high-grade serous ovarian cancer

(2019) Minmin Zhang et al.   OncoTargets and Therapy

Identification of a novel, internal tRNA-derived RNA fragment as a new prognostic and screening biomarker in chronic lymphocytic leukemia, using an innovative quantitative real-time PCR assay

(2019) Katerina Katsaraki et al.   LEUKEMIA RESEARCH

Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors

(2018) Angeliki Giannelou et al.   ANNALS OF THE RHEUMATIC DISEASES

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

(2018) Nicola Guzzi et al.   CELL

Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS

(2018) Hannah M. Burgess et al.   JOURNAL OF VIROLOGY

Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection

(2018) Judy J. Brown et al.   JOURNAL OF VIROLOGY

Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease

(2018) Jihyun Yang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

(2018) Joannie M. Allaire et al.   TRENDS IN IMMUNOLOGY

Probiotic bacteria cell walls stimulate the activity of the intestinal epithelial cells and macrophage functionality

(2018) J.M. Lemme-Dumit et al.   Beneficial Microbes

tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA

(2018) Siqi Li et al.   Genes

Cytokine Tuning of Intestinal Epithelial Function

(2018) Caroline Andrews et al.   Frontiers in Immunology

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

(2018) Ching-Hou Ma et al.   Redox Biology

Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases

(2018) Yijing Shen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A comprehensive understanding of the gut mucosal immune system in allergic inflammation

(2018) Daisuke Tokuhara et al.   ALLERGOLOGY INTERNATIONAL

Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs

(2017) Siqi Li et al.   MOLECULAR NEUROBIOLOGY

A transfer-RNA-derived small RNA regulates ribosome biogenesis

(2017) Hak Kyun Kim et al.   NATURE

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

(2017) Paul Schimmel   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease

(2017) Aaron Buckley et al.   Cold Spring Harbor Perspectives in Biology

An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances Splicing

(2017) Lise Sarah Namer et al.   Cell Reports

Guards at the gate: physiological and pathological roles of tissue-resident innate lymphoid cells in the lung

(2017) Hang Cheng et al.   Protein & Cell

Reactivation of Intestinal Inflammation Is Suppressed by Catestatin in a Murine Model of Colitis via M1 Macrophages and Not the Gut Microbiota

(2017) Mohammad F. Rabbi et al.   Frontiers in Immunology

HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation

(2017) Samantha E. Heron et al.   Frontiers in Immunology

Discriminating Self and Non-Self by RNA: Roles for RNA Structure, Misfolding, and Modification in Regulating the Innate Immune Sensor PKR

(2016) Chelsea M. Hull et al.   ACCOUNTS OF CHEMICAL RESEARCH

TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response

(2016) Zhi-Yuan Li et al.   Aging-US

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein

(2016) Liyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces

(2016) Chigusa Nakahashi-Oda et al.   NATURE IMMUNOLOGY

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

TRNT1 deficiency: clinical, biochemical and molecular genetic features

(2016) Yehani Wedatilake et al.   Orphanet Journal of Rare Diseases

Activation of PKR by short stem–loop RNAs containing single-stranded arms

(2016) Christopher B. Mayo et al.   RNA

The Immunological Basis of Inflammatory Bowel Disease

(2016) Francesca A. R. Silva et al.   Gastroenterology Research and Practice

Regulation of PKR by RNA: Formation of Active and Inactive Dimers

(2015) Bushra Husain et al.   BIOCHEMISTRY

The potential protective role of the combination of IL-22 and TNF-α against genital tract Chlamydia trachomatis infection

(2015) Xiumin Zhao et al.   CYTOKINE

The 3′ addition of CCA to mitochondrial tRNASer(AGY) is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1

(2015) Florin Sasarman et al.   HUMAN MOLECULAR GENETICS

Double Stranded RNA-Dependent Protein Kinase is Necessary for TNF-α-Induced Osteoclast Formation In Vitro and In Vivo

(2015) Hiroki Shinohara et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Involvement of RNA Polymerase III in Immune Responses

(2015) Damian Graczyk et al.   MOLECULAR AND CELLULAR BIOLOGY

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

(2015) Junfang Deng et al.   MOLECULAR THERAPY

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

(2015) Lucas C. Reineke et al.   mBio

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

(2015) Sara R. Selitsky et al.   Scientific Reports

Recombinant Modified Vaccinia Virus Ankara Generating Excess Early Double-Stranded RNA Transiently Activates Protein Kinase R and Triggers Enhanced Innate Immune Responses

(2014) M. Wolferstatter et al.   JOURNAL OF VIROLOGY

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Epithelial Cell Shedding and Barrier Function

(2014) J. M. Williams et al.   VETERINARY PATHOLOGY

tRNAs as regulators of biological processes

(2014) Medha Raina et al.   Frontiers in Genetics

A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD)

(2013) D. H. Wiseman et al.   BLOOD

Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR

(2013) Subba Rao Nallagatla et al.   PLoS One

PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling

(2012) Stewart Siyan Cao et al.   INFLAMMATORY BOWEL DISEASES

Protein Kinase PKR Amplification of Interferon β Induction Occurs through Initiation Factor eIF-2α-mediated Translational Control

(2012) Christopher S. McAllister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large G3BP-induced granules trigger eIF2α phosphorylation

(2012) Lucas C. Reineke et al.   MOLECULAR BIOLOGY OF THE CELL

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein

(2012) W Abbas et al.   Cell Death & Disease

Innate immunity in the small intestine

(2011) Rebeca Santaolalla et al.   CURRENT OPINION IN GASTROENTEROLOGY

Rotavirus-induced IFN-β promotes anti-viral signaling and apoptosis that modulate viral replication in intestinal epithelial cells

(2011) Amena H Frias et al.   Innate Immunity

Emerging role of angiogenin in stress response and cell survival under adverse conditions

(2011) Shuping Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

tRNAs Marked with CCACCA Are Targeted for Degradation

(2011) J. E. Wilusz et al.   SCIENCE

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules

(2009) Paul Anderson et al.   CURRENT BIOLOGY

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template

(2009) Smadar Cohen-Chalamish et al.   Nature Chemical Biology

Modulation of Gene Expression by Human Cytosolic tRNase ZL through 5′-Half-tRNA

(2009) Reyad A. Elbarbary et al.   PLoS One

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

(2008) S. R. Nallagatla et al.   RNA