Guards at the gate: physiological and pathological roles of tissue-resident innate lymphoid cells in the lung

Prostaglandin I2Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses

(2016) Weisong Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response

(2016) Yi Jia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Innate Lymphocyte/Ly6C hi Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance

(2016) Huizhong Xiong et al.   CELL

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

(2016) Saïda Dadi et al.   CELL

Hallmarks of Tissue-Resident Lymphocytes

(2016) Xiying Fan et al.   CELL

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

(2016) Maya R. Karta et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation

(2016) Itziar Martinez-Gonzalez et al.   IMMUNITY

Complement resistance mechanisms of Klebsiella pneumoniae

(2016) Dennis J. Doorduijn et al.   IMMUNOBIOLOGY

Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity

(2016) Laetitia Everaere et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

(2016) Matthew T. Stier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

(2016) Ai Ing Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2

(2016) Erin C. Zook et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Group 2 Innate Lymphoid Cells Promote an Early Antibody Response to a Respiratory Antigen in Mice

(2016) Li Yin Drake et al.   JOURNAL OF IMMUNOLOGY

Synergistically increased ILC2 and Th9 cells in lung tissue jointly promote the pathological process of asthma in mice

(2016) XINYU YING et al.   Molecular Medicine Reports

IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells

(2016) T Mchedlidze et al.   Mucosal Immunology

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

Surfactant Protein-D Is Essential for Immunity to Helminth Infection

(2016) Sumaiyya Thawer et al.   PLoS Pathogens

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung

(2016) Katrien C. De Grove et al.   PLoS One

Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis

(2015) Thomas Wohlfahrt et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection

(2015) Michael C. Abt et al.   Cell Host & Microbe

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation

(2015) Henry J. McSorley et al.   EXPERIMENTAL PARASITOLOGY

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Natural helper cells contribute to pulmonary eosinophilia by producing IL-13 via IL-33/ST2 pathway in a murine model of respiratory syncytial virus infection

(2015) Jing Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

(2015) Yong Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl11b is essential for group 2 innate lymphoid cell development

(2015) Jennifer A. Walker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unique and redundant functions of NKp46+ILC3s in models of intestinal inflammation

(2015) Christina Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Collaborative Interactions between Type 2 Innate Lymphoid Cells and Antigen-Specific CD4+Th2 Cells Exacerbate Murine Allergic Airway Diseases with Prominent Eosinophilia

(2015) Bo Liu et al.   JOURNAL OF IMMUNOLOGY

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

(2015) E D Tait Wojno et al.   Mucosal Immunology

Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis

(2015) A Mohapatra et al.   Mucosal Immunology

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Complementarity and redundancy of IL-22-producing innate lymphoid cells

(2015) Lucille C Rankin et al.   NATURE IMMUNOLOGY

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

(2015) G. Gasteiger et al.   SCIENCE

Innate lymphoid cells: A new paradigm in immunology

(2015) G. Eberl et al.   SCIENCE

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

(2015) Paolo Carrega et al.   Nature Communications

Group 2 innate lymphoid cells and CD4+T cells cooperate to mediate type 2 immune response in mice

(2014) L. Y. Drake et al.   ALLERGY

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid Cells

(2014) Elisa Montaldo et al.   IMMUNITY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense

(2014) Jeremy P. McAleer et al.   IMMUNOLOGICAL REVIEWS

Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells

(2014) Jun Young Hong et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures

(2014) Matthew J. Gold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gata3drives development of RORγt+group 3 innate lymphoid cells

(2014) Nicolas Serafini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enforced Expression of Gata3 in T Cells and Group 2 Innate Lymphoid Cells Increases Susceptibility to Allergic Airway Inflammation in Mice

(2014) A. KleinJan et al.   JOURNAL OF IMMUNOLOGY

IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure

(2014) Koji Iijima et al.   JOURNAL OF IMMUNOLOGY

Conventional NK Cells Can Produce IL-22 and Promote Host Defense in Klebsiella pneumoniae Pneumonia

(2014) X. Xu et al.   JOURNAL OF IMMUNOLOGY

Activation of Type 3 Innate Lymphoid Cells and Interleukin 22 Secretion in the Lungs During Streptococcus pneumoniae Infection

(2014) Laurye Van Maele et al.   JOURNAL OF INFECTIOUS DISEASES

Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy

(2014) H J McSorley et al.   Mucosal Immunology

Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine

(2014) Jennifer K Bando et al.   NATURE IMMUNOLOGY

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells

(2014) Yuefeng Huang et al.   NATURE IMMUNOLOGY

The Transcription Factor AHR Prevents the Differentiation of a Stage 3 Innate Lymphoid Cell Subset to Natural Killer Cells

(2014) Tiffany Hughes et al.   Cell Reports

Recognition Strategies of Group 3 Innate Lymphoid Cells

(2014) Monica Killig et al.   Frontiers in Immunology

Innate Type 2 Immunity Is Associated with Eosinophilic Pleural Effusion in Primary Spontaneous Pneumothorax

(2013) Bo-In Kwon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44

(2013) Timor Glatzer et al.   IMMUNITY

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

New friendships and old feuds: relationships between innate lymphoid cells and microbial communities

(2013) Naomi H Philip et al.   IMMUNOLOGY AND CELL BIOLOGY

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production

(2013) Taylor A. Doherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

(2013) Jan-Eric Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers

(2013) X Yu et al.   Mucosal Immunology

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

(2013) Lucille C Rankin et al.   NATURE IMMUNOLOGY

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1

(2013) Chauncey J Spooner et al.   NATURE IMMUNOLOGY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

(2013) E. Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Innate immune cells in asthma

(2013) Julie Deckers et al.   TRENDS IN IMMUNOLOGY

Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2

(2013) Rebecca Gentek et al.   Frontiers in Immunology

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

(2012) Hergen Spits et al.   Annual Review of Immunology

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

Type 2 innate lymphoid cells: new players in asthma and allergy

(2012) Seth T Scanlon et al.   CURRENT OPINION IN IMMUNOLOGY

Susceptibility and immunity to helminth parasites

(2012) Rick M Maizels et al.   CURRENT OPINION IN IMMUNOLOGY

Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma

(2012) Roel G. J. Klein Wolterink et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

(2012) Jenny Mjösberg et al.   IMMUNITY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

(2012) K. Yasuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Differences between Human NKp44− and NKp44+ RORC+ Innate Lymphoid Cells

(2012) Kerim Hoorweg et al.   Frontiers in Immunology

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

(2011) K. R. Bartemes et al.   JOURNAL OF IMMUNOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

(2011) Christoph Wilhelm et al.   NATURE IMMUNOLOGY

IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease

(2011) Christian Taube et al.   PLoS One

The function of natural killer cells: education, reminders and some good memories

(2010) Werner Held et al.   CURRENT OPINION IN IMMUNOLOGY

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

(2010) L. Van Maele et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1  reveals intrinsic functional plasticity

(2010) M. Cella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

Amphiregulin attenuates bleomycin-induced pneumopathy in mice

(2009) Jutaro Fukumoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Cytokine Network in Chronic Obstructive Pulmonary Disease

(2009) Peter J. Barnes   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Body mass index and phenotype in subjects with mild-to-moderate persistent asthma

(2009) E. Rand Sutherland et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function

(2009) J. C. Massacand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY