Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

(2018) Nicola Guzzi et al.   CELL

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

(2018) Canan Kuscu et al.   RNA

PtRFdb: a database for plant transfer RNA-derived fragments

(2018) Nikita Gupta et al.   Database-The Journal of Biological Databases and Curation

tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA

(2018) Siqi Li et al.   Genes

Argonaute and the Nuclear RNAs: New Pathways for RNA-Mediated Control of Gene Expression

(2018) Keith T. Gagnon et al.   Nucleic Acid Therapeutics

Impact of microRNA-375 and its target gene SMAD-7 polymorphism on susceptibility of colorectal cancer

(2017) Olfat Gamil Shaker et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Prognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer

(2017) Zhen-Lin Nie et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance

(2017) Mengqian Tian et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection

(2017) Tianwen Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The discovery potential of RNA processing profiles

(2017) Amadís Pagès et al.   NUCLEIC ACIDS RESEARCH

SPOt: A novel and streamlined microarray platform for observing cellular tRNA levels

(2017) Simon Grelet et al.   PLoS One

Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

(2017) Shawn M. Lyons et al.   Nature Communications

Regulatory mechanisms of long noncoding RNAs on gene expression in cancers

(2017) Weiliang Sun et al.   Cancer Genetics

Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety

(2017) A K Short et al.   Translational Psychiatry

Noncoding RNA: Current Deep Sequencing Data Analysis Approaches and Challenges

(2016) Dario Veneziano et al.   HUMAN MUTATION

IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells

(2016) Xue Zhang et al.   JOURNAL OF IMMUNOLOGY

tRNA-Derived RNA Fragments Associate with Human Multisynthetase Complex (MSC) and Modulate Ribosomal Protein Translation

(2016) Simon P. Keam et al.   JOURNAL OF PROTEOME RESEARCH

A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress

(2016) Jennifer Gebetsberger et al.   RNA Biology

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

(2016) Pankaj Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

A comprehensive repertoire of tRNA-derived fragments in prostate cancer

(2016) Michael Olvedy et al.   Oncotarget

Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets

(2015) Spyros Karaiskos et al.   Biology Direct

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

(2015) Junfang Deng et al.   MOLECULAR THERAPY

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Differential and coherent processing patterns from small RNAs

(2015) Sachin Pundhir et al.   Scientific Reports

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

(2015) Sara R. Selitsky et al.   Scientific Reports

Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

(2014) Pankaj Kumar et al.   BMC BIOLOGY

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

(2014) Ender Karaca et al.   CELL

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage

(2014) E. Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

tRFdb: a database for transfer RNA fragments

(2014) Pankaj Kumar et al.   NUCLEIC ACIDS RESEARCH

Beyond microRNA – Novel RNAs derived from small non-coding RNA and their implication in cancer

(2013) Elena S. Martens-Uzunova et al.   CANCER LETTERS

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Comprehensive Expression Profile of MicroRNAs and Other Classes of Non-Coding Small RNAs in Barley Under Phosphorous-Deficient and -Sufficient Conditions

(2012) M. Hackenberg et al.   DNA RESEARCH

Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress

(2012) Mridusmita Saikia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

A Tetrahymena Piwi Bound to Mature tRNA 3′ Fragments Activates the Exonuclease Xrn2 for RNA Processing in the Nucleus

(2012) Mary T. Couvillion et al.   MOLECULAR CELL

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

High throughput sequencing reveals a plethora of small RNAs including tRNA derived fragments inHaloferax volcanii

(2012) Ruth Heyer et al.   RNA Biology

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

(2011) Michael A. van Es et al.   ANNALS OF NEUROLOGY

Emerging role of angiogenin in stress response and cell survival under adverse conditions

(2011) Shuping Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

A miRNA-tRNA mix-up: tRNA origin of proposed miRNA

(2011) Nick C.T. Schopman et al.   RNA Biology

Genome-wide discovery and analysis of microRNAs and other small RNAs from rice embryogenic callus

(2011) Chong-Jian Chen et al.   RNA Biology

A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo

(2010) M. T. Couvillion et al.   GENES & DEVELOPMENT

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel MicroRNA-Like Molecules Generated from Herpesvirus and Host tRNA Transcripts

(2010) T. A. Reese et al.   JOURNAL OF VIROLOGY

Pontocerebellar hypoplasia: Clinical, pathologic, and genetic studies

(2010) D. Cassandrini et al.   NEUROLOGY

Regulatory RNAs derived from transfer RNA?

(2010) T. Pederson   RNA

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid

(2009) Man Lung Yeung et al.   NUCLEIC ACIDS RESEARCH

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

Hidden layers of human small RNAs

(2008) Hideya Kawaji et al.   BMC GENOMICS

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Endogenous small interfering RNAs in animals

(2008) Katsutomo Okamura et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA

Preserving Accuracy in GenBank

(2008) M. I. Bidartondo   SCIENCE