Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein

ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury

(2016) Hui Wang et al.   Scientific Reports

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

(2015) Meihong Deng et al.   Science Signaling

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

(2015) Meihong Deng et al.   Science Signaling

Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses

(2014) Zhiyong Ma et al.   Cellular & Molecular Immunology

How the Innate Immune System Senses Trouble and Causes Trouble

(2014) T. Hato et al.   Clinical Journal of the American Society of Nephrology

The Inducible Nitric-oxide Synthase (iNOS)/Src Axis Mediates Toll-like Receptor 3 Tyrosine 759 Phosphorylation and Enhances Its Signal Transduction, Leading to Interferon-β Synthesis in Macrophages

(2014) Ming-Yu Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

(2014) Shengyong Yang et al.   JOURNAL OF IMMUNOLOGY

Long-term stimulation of Toll-like receptor 3 in primary human hepatocytes leads to sensitization for antiviral responses induced by poly I:C treatment

(2014) R. Broering et al.   JOURNAL OF VIRAL HEPATITIS

Molecular mechanisms of hepatic apoptosis

(2014) K Wang   Cell Death & Disease

The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages

(2013) Yuan He et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly-I:C

(2013) Tyler C. Moore et al.   FEBS LETTERS

Toll Like Receptor 3 Plays a Critical Role in the Progression and Severity of Acetaminophen-Induced Hepatotoxicity

(2013) Karen A. Cavassani et al.   PLoS One

The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells

(2013) Lumin Zhang et al.   VIROLOGY

Disruption of Type-I IFN Pathway Ameliorates Preservation Damage in Mouse Orthotopic Liver Transplantation via HO-1 Dependent Mechanism

(2012) X.-D. Shen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury

(2012) Patrizia Loi et al.   HEPATOLOGY

A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes

(2012) R. Savanh Chanthaphavong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR3, TRIF, and Caspase 8 Determine Double-Stranded RNA-Induced Epithelial Cell Death and Survival In Vivo

(2012) C. S. McAllister et al.   JOURNAL OF IMMUNOLOGY

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

The Nitric Oxide Pathway Provides Innate Antiviral Protection in Conjunction with the Type I Interferon Pathway in Fibroblasts

(2012) Devangi R. Mehta et al.   PLoS One

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

(2012) K.-G. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling

(2012) M. Yamashita et al.   Science Signaling

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Characterization of DISC Formation and TNFR1 Translocation to Mitochondria in TNF-α–Treated Hepatocytes

(2011) Hyun-Ae Eum et al.   AMERICAN JOURNAL OF PATHOLOGY

The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages

(2010) Ming-Chei Maa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress

(2010) Liyong Zhang et al.   EMBO JOURNAL

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Toll-like receptor 3 signaling attenuates liver regeneration

(2009) Elina Zorde-Khvalevsky et al.   HEPATOLOGY

Inflammatory Regulation by TLR3 in Acute Hepatitis

(2009) X. Xiao et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3

(2008) E. Vercammen et al.   CLINICAL MICROBIOLOGY REVIEWS

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Macrophages in Hepatitis B and Hepatitis C Virus Infections

(2008) M. Heydtmann   JOURNAL OF VIROLOGY