The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription

(2020) Claire D. James et al.   mSphere

The Role of microRNAs, Long Non-coding RNAs, and Circular RNAs in Cervical Cancer

(2020) Maria Lina Tornesello et al.   Frontiers in Oncology

Promoter methylation of tumor suppressor genes induced by human papillomavirus in cervical cancer

(2020) Pattamawadee Yanatatsaneejit et al.   Oncology Letters

A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

(2020) Takuya Tomita et al.   Nature Communications

Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers

(2020) Theofano Panayiotou et al.   PLoS Pathogens

The Role of Long Noncoding RNAs in Human Papillomavirus-associated Pathogenesis

(2020) Surendra Sharma et al.   Pathogens

BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma

(2020) Fang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

(2020) Ethan L. Morgan et al.   PLoS Pathogens

Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies

(2020) Ethan L. Morgan et al.   Viruses-Basel

The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation

(2020) Masaru Shimada et al.   Scientific Reports

E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer

(2020) Ethan L. Morgan et al.   CELL DEATH AND DIFFERENTIATION

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

(2019) Chunbo He et al.   Cell Reports

PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis

(2019) Joshua Hatterschide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human papillomavirus E6/E7 and lncRNA TMPOP2 mutually upregulated gene expression in cervical cancer cells

(2019) Hongpeng He et al.   JOURNAL OF VIROLOGY

E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1

(2019) Camille M. Drews et al.   PLoS Pathogens

hsa_circ_0000745 promotes cervical cancer by increasing cell proliferation, migration, and invasion

(2019) Jun Jiao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade

(2019) Yu Guo et al.   ONCOGENE

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus

(2019) Jiawei Zhao et al.   Nature Communications

Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus

(2019) Hye-Yeoung Yun et al.   PLOS BIOLOGY

Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis

(2019) Ethan L. Morgan et al.   PLoS Pathogens

CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)

(2019) Katherine Harper et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

HPV E7 Oncoprotein Subverts Host Innate Immunity Via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes

(2019) Irene Lo Cigno et al.   JOURNAL OF VIROLOGY

Human papillomavirus type 16 E5 inhibits interferon signaling and supports episomal viral maintenance

(2019) Matthew L. Scott et al.   JOURNAL OF VIROLOGY

HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer

(2019) Sayuri Miyauchi et al.   CANCER RESEARCH

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

(2019) Xiaobo Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death

(2019) Ethan L. Morgan et al.   Cancers

Up-regulation of miR-20a by HPV16 E6 exerts growth-promoting effects by targeting PDCD6 in cervical carcinoma cells

(2018) Xin Liu   BIOMEDICINE & PHARMACOTHERAPY

HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting miR-23b /MAPK1 axis

(2018) Qin Li et al.   BIOSCIENCE REPORTS

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

(2018) Jiamei Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys

(2018) Elektra Peta et al.   ONCOGENE

Expression of the cervical carcinoma expressed PCNA regulatory (CCEPR) long noncoding RNA is driven by the human papillomavirus E6 protein and modulates cell proliferation independent of PCNA

(2018) Surendra Sharma et al.   VIROLOGY

Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization

(2018) Sydney Webb Strickland et al.   VIROLOGY

Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes

(2018) Matthew L. Scott et al.   VIROLOGY

Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification

(2018) Kavi Mehta et al.   mBio

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

(2018) Ethan L. Morgan et al.   PLoS Pathogens

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5

(2018) Laura F. Wetherill et al.   ANTIVIRAL RESEARCH

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking

(2018) Pengwei Zhang et al.   CELL

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

KDM5 histone demethylases repress immune response via suppression of STING

(2018) Lizhen Wu et al.   PLOS BIOLOGY

LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR-335-5p

(2018) Huiling Liang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Worldwide burden of cancer attributable to HPV by site, country and HPV type

(2017) Catherine de Martel et al.   INTERNATIONAL JOURNAL OF CANCER

LINC01101 and LINC00277 expression levels as novel factors in HPV-induced cervical neoplasia

(2017) Iulia Virginia Iancu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Suppression of MicroRNA 424 Levels by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification

(2017) Shiyuan Hong et al.   JOURNAL OF VIROLOGY

The PTPN14 Tumor Suppressor Is a Degradation Target of Human Papillomavirus E7

(2017) Anita Szalmás et al.   JOURNAL OF VIROLOGY

The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling

(2017) Cindy Chiang et al.   JOURNAL OF VIROLOGY

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Human papillomavirus E6-regulated microRNA-20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2

(2017) Yuan Cheng et al.   Molecular Medicine Reports

HPV entry into cells

(2017) Pinar Aksoy et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Integrated genomic and molecular characterization of cervical cancer

(2017)   NATURE

Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation

(2017) Alexander G. Karabadzhak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Papillomavirus assembly: An overview and perspectives

(2017) Carla Cerqueira et al.   VIRUS RESEARCH

Telomerase Induction in HPV Infection and Oncogenesis

(2017) Rachel Katzenellenbogen   Viruses-Basel

Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin

(2017) Steven F. Gameiro et al.   Oncotarget

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

(2017) Christopher W. Wasson et al.   Oncotarget

KDM6A addiction of cervical carcinoma cell lines is triggered by E7 and mediated by p21CIP1 suppression of replication stress

(2017) David R. Soto et al.   PLoS Pathogens

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry

(2017) Inci Aydin et al.   PLoS Pathogens

The role of integration in oncogenic progression of HPV-associated cancers

(2017) Alison A. McBride et al.   PLoS Pathogens

Identification of Novel Long Non-coding and Circular RNAs in Human Papillomavirus-Mediated Cervical Cancer

(2017) Hongbo Wang et al.   Frontiers in Microbiology

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Papillomavirus Episteme: a major update to the papillomavirus sequence database

(2016) Koenraad Van Doorslaer et al.   NUCLEIC ACIDS RESEARCH

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma

(2016) M Hazawa et al.   ONCOGENE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14

(2016) Louis Cicchini et al.   mBio

High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation

(2016) Elizabeth A. White et al.   mBio

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways

(2016) Ketaki Ganti et al.   PLoS Pathogens

Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential

(2016) Miranda Thomas et al.   PLoS Pathogens

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

Human papillomavirus E5 oncoprotein: function and potential target for antiviral therapeutics

(2015) Marietta Müller et al.   Future Virology

HPV 16 E2 binding sites 1 and 2 become more methylated than E2 binding site 4 during cervical carcinogenesis

(2015) Tsin-Wah Leung et al.   JOURNAL OF MEDICAL VIROLOGY

The Acetyltransferase Tip60 Is a Critical Regulator of the Differentiation-Dependent Amplification of Human Papillomaviruses

(2015) Shiyuan Hong et al.   JOURNAL OF VIROLOGY

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Human papillomavirus molecular biology and disease association

(2015) John Doorbar et al.   REVIEWS IN MEDICAL VIROLOGY

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA

(2015) Meng Yang et al.   TUMOR BIOLOGY

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

(2015) Ketaki Ganti et al.   Viruses-Basel

Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

(2015) Jamie Royle et al.   Viruses-Basel

E6^E7, a Novel Splice Isoform Protein of Human Papillomavirus 16, Stabilizes Viral E6 and E7 Oncoproteins via HSP90 and GRP78

(2015) Masahiko Ajiro et al.   mBio

STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication

(2015) Shiyuan Hong et al.   mBio

YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins

(2015) Marietta Müller et al.   Scientific Reports

The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes

(2015) Kathryn H. Richards et al.   Scientific Reports

Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis

(2015) Sweta Sharma et al.   Scientific Reports

Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection

(2015) Andreea Popa et al.   PLoS Pathogens

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition

(2014) Danilo Ranieri et al.   INTERNATIONAL JOURNAL OF CANCER

The Human Papillomavirus E7 Proteins Associate with p190RhoGAP and Alter Its Function

(2014) B. Todorovic et al.   JOURNAL OF VIROLOGY

Human Papillomavirus E7 Oncoprotein Increases Production of the Anti-Inflammatory Interleukin-18 Binding Protein in Keratinocytes

(2014) K. H. Richards et al.   JOURNAL OF VIROLOGY

The nuclear retention signal of HPV16 L2 protein is essential for incoming viral genome to transverse the trans-Golgi network

(2014) Stephen DiGiuseppe et al.   VIROLOGY

HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling

(2014) Sophia Sominsky et al.   VIROLOGY

Human papillomavirus E5 oncoproteins bind the A4 endoplasmic reticulum protein to regulate proliferative ability upon differentiation

(2014) Katarina Kotnik Halavaty et al.   VIROLOGY

The role of MALAT1 correlates with HPV in cervical cancer

(2014) YAN JIANG et al.   Oncology Letters

Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses

(2014) Inci Aydin et al.   PLoS Pathogens

HPV16-E7 Expression in Squamous Epithelium Creates a Local Immune Suppressive Environment via CCL2- and CCL5- Mediated Recruitment of Mast Cells

(2014) Anne-Sophie Bergot et al.   PLoS Pathogens

Up-Regulation of FOXM1 by E6 Oncoprotein through the MZF1/NKX2-1 Axis Is Required for Human Papillomavirus–Associated Tumorigenesis

(2014) Po-Ming Chen et al.   NEOPLASIA

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation of the NOTCH Pathway in Head and Neck Cancer

(2013) W. Sun et al.   CANCER RESEARCH

The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin

(2013) Anna M. Mileo et al.   CARCINOGENESIS

The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter

(2013) Uzma A. Hasan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NFX1-123 and Human Papillomavirus 16E6 Increase Notch Expression in Keratinocytes

(2013) P. A. Vliet-Gregg et al.   JOURNAL OF VIROLOGY

Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection

(2013) P. M. Day et al.   JOURNAL OF VIROLOGY

A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c)

(2013) C L Pang et al.   ONCOGENE

Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus

(2013) A. Lipovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear import of high risk HPV16 E7 oncoprotein is mediated by its zinc-binding domain via hydrophobic interactions with Nup62

(2013) Jeremy Eberhard et al.   VIROLOGY

Diseases associated with human papillomavirus infection

(2013) Heather A. Cubie   VIROLOGY

The E5 proteins

(2013) Daniel DiMaio et al.   VIROLOGY

The E1 proteins

(2013) Monika Bergvall et al.   VIROLOGY

The Papillomavirus E2 proteins

(2013) Alison A. McBride   VIROLOGY

Papillomavirus E6 oncoproteins

(2013) Scott B. Vande Pol et al.   VIROLOGY

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

(2013) Jennifer M. Spangle et al.   PLoS Pathogens

The JAK-STAT Transcriptional Regulator, STAT-5, Activates the ATM DNA Damage Pathway to Induce HPV 31 Genome Amplification upon Epithelial Differentiation

(2013) Shiyuan Hong et al.   PLoS Pathogens

Cervical Cancers Require the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncoprotein Even in the Presence of the Viral E6 Oncoprotein

(2012) Sean F. Jabbar et al.   CANCER RESEARCH

Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women

(2012) S. M. Leonard et al.   CARCINOGENESIS

Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor Suppressor

(2012) B. Todorovic et al.   JOURNAL OF VIROLOGY

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Human Papillomaviruses Recruit Cellular DNA Repair and Homologous Recombination Factors to Viral Replication Centers

(2012) K. A. Gillespie et al.   JOURNAL OF VIROLOGY

Cyclophilins Facilitate Dissociation of the Human Papillomavirus Type 16 Capsid Protein L1 from the L2/DNA Complex following Virus Entry

(2012) Malgorzata Bienkowska-Haba et al.   JOURNAL OF VIROLOGY

Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity

(2012) E. A. White et al.   JOURNAL OF VIROLOGY

High-Risk Human Papillomavirus E6 Oncoproteins Interact with 14-3-3ζ in a PDZ Binding Motif-Dependent Manner

(2012) Siaw Shi Boon et al.   JOURNAL OF VIROLOGY

The PxDLLCxE Sequence in Conserved Region 2 of Human Papilloma Virus 18 Protein E7 Is Required for E7 Binding to Centromere Protein C

(2012) Yuji Yaginuma et al.   ONCOLOGY

Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses

(2012) E. A. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer

(2012) M. Herfs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

(2012) Katia Zanier et al.   STRUCTURE

Association between hTERT activation by HPV E6 proteins and oncogenic risk

(2012) Koenraad Van Doorslaer et al.   VIROLOGY

Entry of Human Papillomavirus Type 16 by Actin-Dependent, Clathrin- and Lipid Raft-Independent Endocytosis

(2012) Mario Schelhaas et al.   PLoS Pathogens

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Human Papillomavirus (HPV)E7Induces Prolonged G2following S Phase Reentry in Differentiated Human Keratinocytes

(2011) N. Sanjib Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells

(2011) N. Nor Rashid et al.   JOURNAL OF GENERAL VIROLOGY

The Human Papillomavirus Type 16 E5 Oncoprotein Translocates Calpactin I to the Perinuclear Region

(2011) E. Krawczyk et al.   JOURNAL OF VIROLOGY

High-Risk Human Papillomaviruses Repress Constitutive Kappa Interferon Transcription via E6 To Prevent Pathogen Recognition Receptor and Antiviral-Gene Expression

(2011) J. Reiser et al.   JOURNAL OF VIROLOGY

E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1

(2011) R. Accardi et al.   JOURNAL OF VIROLOGY

The E6 Oncoprotein from HPV16 Enhances the Canonical Wnt/ -Catenin Pathway in Skin Epidermis In Vivo

(2011) J. Bonilla-Delgado et al.   MOLECULAR CANCER RESEARCH

The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription

(2011) C-H Hsu et al.   ONCOGENE

HPV16 E5 affects the KGFR/FGFR2b-mediated epithelial growth through alteration of the receptor expression, signaling and endocytic traffic

(2011) F Belleudi et al.   ONCOGENE

Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming

(2011) Margaret E. McLaughlin-Drubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1

(2011) Dieter Morandell et al.   VIROLOGY

Genomic instability and cancer: Lessons learned from human papillomaviruses

(2010) Nina Korzeniewski et al.   CANCER LETTERS

Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer

(2010) R.-K. Lin et al.   CANCER RESEARCH

Human Papillomavirus E7 Enhances Hypoxia-Inducible Factor 1-Mediated Transcription by Inhibiting Binding of Histone Deacetylases

(2010) J. M. Bodily et al.   CANCER RESEARCH

A Role for HPV16 E5 in Cervical Carcinogenesis

(2010) John P. Maufort et al.   CANCER RESEARCH

Pathology and epidemiology of HPV infection in females

(2010) Margaret Stanley   GYNECOLOGIC ONCOLOGY

The Human Papillomavirus Type 16 E5 Oncoprotein Inhibits Epidermal Growth Factor Trafficking Independently of Endosome Acidification

(2010) Frank A. Suprynowicz et al.   JOURNAL OF VIROLOGY

CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV

(2010) S. Miura et al.   JOURNAL OF VIROLOGY

Human Papillomaviruses Modulate Expression of MicroRNA 203 upon Epithelial Differentiation to Control Levels of p63 Proteins

(2010) M. Melar-New et al.   JOURNAL OF VIROLOGY

The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis

(2010) J. M. Spangle et al.   JOURNAL OF VIROLOGY

Activation of Wnt Signaling Pathway by Human Papillomavirus E6 and E7 Oncogenes in HPV16-Positive Oropharyngeal Squamous Carcinoma Cells

(2010) T. Rampias et al.   MOLECULAR CANCER RESEARCH

Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway

(2010) Sudhakar Jha et al.   MOLECULAR CELL

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53

(2010) Kwok   ONCOLOGY REPORTS

The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27Kip1

(2010) Adolfo Pedroza-Saavedra et al.   VIROLOGY

HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells

(2010) M.S. Campo et al.   VIROLOGY

Human papillomavirus type 16 E5 protein inhibits hydrogen peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells

(2009) J.-M. Oh et al.   CARCINOGENESIS

Robust production and passaging of infectious HPV in squamous epithelium of primary human keratinocytes

(2009) H.-K. Wang et al.   GENES & DEVELOPMENT

All 4 di-leucine motifs in the first hydrophobic domain of the E5 oncoprotein of human papillomavirus type 16 are essential for surface MHC class I downregulation activity and E5 endomembrane localization

(2009) Marc S. Cortese et al.   INTERNATIONAL JOURNAL OF CANCER

The Ubiquitin-Specific Peptidase USP15 Regulates Human Papillomavirus Type 16 E6 Protein Stability

(2009) R. M. Vos et al.   JOURNAL OF VIROLOGY

Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway

(2009) A C Hoover et al.   ONCOGENE

Human Papillomavirus-16 E7 Interacts with Glutathione S-Transferase P1 and Enhances Its Role in Cell Survival

(2009) Anna M. Mileo et al.   PLoS One

HPV E6 protein interacts physically and functionally with the cellular telomerase complex

(2009) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6

(2009) X. Wang et al.   RNA

Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression

(2009) Dohun Pyeon et al.   PLoS Pathogens

Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

(2009) Cary A. Moody et al.   PLoS Pathogens

Karyopherin β3: A new cellular target for the HPV-16 E5 oncoprotein

(2008) Ewa Krawczyk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of the CYLD Deubiquitinase by HPV E6 Mediates Hypoxia-Induced NF-κB Activation

(2008) Jiabin An et al.   CANCER CELL

E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6

(2008) Li Zheng et al.   GENES TO CELLS

DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues☆

(2008) Yuh-Jin Liang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins

(2008) Gary A. Clawson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human Papillomavirus E7 Protein Deregulates Mitosis via an Association with Nuclear Mitotic Apparatus Protein 1

(2008) C. L. Nguyen et al.   JOURNAL OF VIROLOGY

Casein Kinase II Motif-Dependent Phosphorylation of Human Papillomavirus E7 Protein Promotes p130 Degradation and S-Phase Induction in Differentiated Human Keratinocytes

(2008) N. J. Genovese et al.   JOURNAL OF VIROLOGY

Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein

(2008) J. A. Regan et al.   JOURNAL OF VIROLOGY

Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6

(2008) M. E. McLaughlin-Drubin et al.   JOURNAL OF VIROLOGY

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes

(2008) Christine L. Nguyen et al.   VIROLOGY

The human papillomavirus E7 oncoprotein

(2008) Margaret E. McLaughlin-Drubin et al.   VIROLOGY

Identification of the nuclear localization and export signals of high risk HPV16 E7 oncoprotein

(2008) Alixandra A. Knapp et al.   VIROLOGY

Papillomavirus E6 proteins

(2008) Heather L. Howie et al.   VIROLOGY

E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway

(2008) Adriana Contreras-Paredes et al.   VIROLOGY