The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

Targeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High-Affinity Bivalent Ligand

(2015) Juan Ramirez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay

(2015) Renaud Vincentelli et al.   NATURE METHODS

Degradation of Human PDZ-Proteins by Human Alphapapillomaviruses Represents an Evolutionary Adaptation to a Novel Cellular Niche

(2015) Koenraad Van Doorslaer et al.   PLoS Pathogens

Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

(2014) M. E. Feigin et al.   CANCER RESEARCH

Restoration of MAGI-1 Expression in Human Papillomavirus-Positive Tumor Cells Induces Cell Growth Arrest and Apoptosis

(2014) C. Kranjec et al.   JOURNAL OF VIROLOGY

PDZRN3/LNX3 Is a Novel Target of Human Papillomavirus Type 16 (HPV-16) and HPV-18 E6

(2014) Miranda Thomas et al.   JOURNAL OF VIROLOGY

Cancer-Causing Human Papillomavirus E6 Proteins Display Major Differences in the Phospho-Regulation of Their PDZ Interactions

(2014) Siaw Shi Boon et al.   JOURNAL OF VIROLOGY

Human papillomavirus (HPV)-18 E6 oncoprotein interferes with the epithelial cell polarity Par3 protein

(2014) Florencia Facciuto et al.   Molecular Oncology

Rewiring cell polarity signaling in cancer

(2014) R Halaoui et al.   ONCOGENE

The Burden of HPV-Associated Anogenital Cancers

(2014) Katie Wakeham et al.   Current Oncology Reports

The Human Adenovirus E4-ORF1 Protein Subverts Discs Large 1 to Mediate Membrane Recruitment and Dysregulation of Phosphatidylinositol 3-Kinase

(2014) Kathleen Kong et al.   PLoS Pathogens

Human Papillomavirus in Head and Neck Cancer

(2014) Anna Garbuglia   Cancers

Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures

(2013) Fei Ye et al.   BIOCHEMICAL JOURNAL

Complexities of Crumbs Function and Regulation in Tissue Morphogenesis

(2013) Shirin Meher Pocha et al.   CURRENT BIOLOGY

The Role of Protein Kinase A Regulation of the E6 PDZ-Binding Domain during the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 18

(2013) C. P. Delury et al.   JOURNAL OF VIROLOGY

Papillomavirus E6 PDZ Interactions Can Be Replaced by Repression of p53 To Promote Episomal Human Papillomavirus Genome Maintenance

(2013) N. Brimer et al.   JOURNAL OF VIROLOGY

The Human PDZome: A Gateway to PSD95-Disc Large-Zonula Occludens (PDZ)-mediated Functions

(2013) Edwige Belotti et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

(2013) K. Zanier et al.   SCIENCE

Papillomavirus E6 oncoproteins

(2013) Scott B. Vande Pol et al.   VIROLOGY

Human papillomaviruses and the specificity of PDZ domain targeting

(2012) David Pim et al.   FEBS Journal

Differential expression of PDZ domain-containing proteins in human diseases - challenging topics and novel issues

(2012) Florencia Facciuto et al.   FEBS Journal

The PDZ protein discs-large (DLG): the ‘Jekyll and Hyde’ of the epithelial polarity proteins

(2012) Sally Roberts et al.   FEBS Journal

Plasticity of PDZ domains in ligand recognition and signaling

(2012) Ylva Ivarsson   FEBS LETTERS

High-Risk Human Papillomavirus E6 Oncoproteins Interact with 14-3-3ζ in a PDZ Binding Motif-Dependent Manner

(2012) Siaw Shi Boon et al.   JOURNAL OF VIROLOGY

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

(2012) Orit Rozenblatt-Rosen et al.   NATURE

The Papillomavirus Episteme: a central resource for papillomavirus sequence data and analysis

(2012) Koenraad Van Doorslaer et al.   NUCLEIC ACIDS RESEARCH

Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

(2012) Katia Zanier et al.   STRUCTURE

The Invasive Capacity of HPV Transformed Cells Requires the hDlg-Dependent Enhancement of SGEF/RhoG Activity

(2012) Vanitha Krishna Subbaiah et al.   PLoS Pathogens

Emerging Role for Epithelial Polarity Proteins of the Crumbs Family as Potential Tumor Suppressors

(2011) Patrick Laprise   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

(2011) Helen B. Pearson et al.   JOURNAL OF CLINICAL INVESTIGATION

The Structural and Dynamic Response of MAGI-1 PDZ1 with Noncanonical Domain Boundaries to the Binding of Human Papillomavirus E6

(2011) Sebastian Charbonnier et al.   JOURNAL OF MOLECULAR BIOLOGY

E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1

(2011) R. Accardi et al.   JOURNAL OF VIROLOGY

A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration and is associated with breast cancer progression

(2011) J N Anastas et al.   ONCOGENE

Epithelial organization, cell polarity and tumorigenesis

(2011) Luke Martin McCaffrey et al.   TRENDS IN CELL BIOLOGY

Dominant role of HPV16 E7 in anal carcinogenesis

(2011) Marie K. Thomas et al.   VIROLOGY

Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance

(2011) Lietta Nicolaides et al.   VIROLOGY

Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation

(2011) Thomas G. Magaldi et al.   VIROLOGY

Surface plasmon resonance analysis of the binding of high-risk mucosal HPV E6 oncoproteins to the PDZ1 domain of the tight junction protein MAGI-1

(2010) Sadek Fournane et al.   JOURNAL OF MOLECULAR RECOGNITION

A Systematic Analysis of Human Papillomavirus (HPV) E6 PDZ Substrates Identifies MAGI-1 as a Major Target of HPV Type 16 (HPV-16) and HPV-18 Whose Loss Accompanies Disruption of Tight Junctions

(2010) C. Kranjec et al.   JOURNAL OF VIROLOGY

hScrib, a Human Homolog of Drosophila Neoplastic Tumor Suppressor, Is Involved in the Progress of Endometrial Cancer

(2010) Zhuo Ouyang et al.   ONCOLOGY RESEARCH

Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice

(2010) Sean Jabbar et al.   VIROLOGY

Persistence of High-Grade Cervical Dysplasia and Cervical Cancer Requires the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncogene

(2009) S. F. Jabbar et al.   CANCER RESEARCH

Robust production and passaging of infectious HPV in squamous epithelium of primary human keratinocytes

(2009) H.-K. Wang et al.   GENES & DEVELOPMENT

A review of human carcinogens—Part B: biological agents

(2009) Véronique Bouvard et al.   LANCET ONCOLOGY

The stability of the human papillomavirus E6 oncoprotein is E6AP dependent

(2009) Vjekoslav Tomaić et al.   VIROLOGY

Binding of PDZ proteins to HPV E6 proteins does neither correlate with epidemiological risk classification nor with the immortalization of foreskin keratinocytes

(2009) Peter Muench et al.   VIROLOGY

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

(2008) P O Humbert et al.   ONCOGENE

Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators

(2008) V Tomaić et al.   ONCOGENE

E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway

(2008) Adriana Contreras-Paredes et al.   VIROLOGY

A Specificity Map for the PDZ Domain Family

(2008) Raffi Tonikian et al.   PLOS BIOLOGY

Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells

(2007) William C. Spanos et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK