Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis

HPV: Molecular pathways and targets

(2018) Shilpi Gupta et al.   CURRENT PROBLEMS IN CANCER

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

(2018) Ethan L. Morgan et al.   PLoS Pathogens

Viral manipulation of STAT3: Evade, exploit, and injure

(2018) Armando Andres Roca Suarez et al.   PLoS Pathogens

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5

(2018) Laura F. Wetherill et al.   ANTIVIRAL RESEARCH

IL6 is associated with response to dasatinib and cetuximab: Phase II clinical trial with mechanistic correlatives in cetuximab-resistant head and neck cancer

(2017) L.P. Stabile et al.   ORAL ONCOLOGY

Somatic Host Cell Alterations in HPV Carcinogenesis

(2017) Tamara Litwin et al.   Viruses-Basel

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

(2017) Christopher W. Wasson et al.   Oncotarget

Rac1 promotes chondrogenesis by regulating STAT3 signaling pathway

(2016) Hyoin Kim et al.   CELL BIOLOGY INTERNATIONAL

Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma

(2016) Jureeporn Chuerduangphui et al.   MEDICAL ONCOLOGY

Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma

(2016) JIAN GAO et al.   ONCOLOGY REPORTS

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells

(2016) Wani Arjumand et al.   Oncotarget

Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis

(2016) Jayesh Deshmukh et al.   Oncotarget

Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential

(2016) Miranda Thomas et al.   PLoS Pathogens

Expression of IL-1α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer

(2016) Zhiwang Song et al.   MEDICAL SCIENCE MONITOR

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma

(2015) Aditya Stanam et al.   Molecular Oncology

Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)

(2015) JOSÉ VERÍSSIMO FERNANDES et al.   Oncology Letters

EGFR signaling patterns are regulated by its different ligands

(2014) Stine Louise Jeppe Knudsen et al.   GROWTH FACTORS

Dynamic Reprogramming of Signaling Upon Met Inhibition Reveals a Mechanism of Drug Resistance in Gastric Cancer

(2014) A. Z. Lai et al.   Science Signaling

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

Human papillomavirus (HPV) deregulation of Toll-like receptor 9

(2014) Uzma Hasan   OncoImmunology

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

The IκB kinase complex in NF-κB regulation and beyond

(2013) Michael Hinz et al.   EMBO REPORTS

Merkel Cell Polyomavirus Small T Antigen Targets the NEMO Adaptor Protein To Disrupt Inflammatory Signaling

(2013) D. A. Griffiths et al.   JOURNAL OF VIROLOGY

Human papillomavirus and cervical cancer

(2013) Emma J Crosbie et al.   LANCET

Functional Regulatory Role of STAT3 in HPV16-Mediated Cervical Carcinogenesis

(2013) Shirish Shukla et al.   PLoS One

Oncogenic PI3K Mutations Lead to NF- B-Dependent Cytokine Expression following Growth Factor Deprivation

(2012) J. E. Hutti et al.   CANCER RESEARCH

Human papillomaviruses and the specificity of PDZ domain targeting

(2012) David Pim et al.   FEBS Journal

Unknown

(2012) Alexandra Lucs et al.   MOLECULAR MEDICINE

Cross-Talk between NFkB and the PI3-Kinase/AKT Pathway Can Be Targeted in Primary Effusion Lymphoma (PEL) Cell Lines for Efficient Apoptosis

(2012) Azhar R. Hussain et al.   PLoS One

Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas

(2012) Chun-Yi Chuang et al.   PLoS One

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization

(2012) Erik R. Vandermark et al.   VIROLOGY

Human Papillomavirus (HPV)E7Induces Prolonged G2following S Phase Reentry in Differentiated Human Keratinocytes

(2011) N. Sanjib Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness

(2011) David M Winder et al.   JOURNAL OF PATHOLOGY

IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway

(2011) A. Yadav et al.   MOLECULAR CANCER RESEARCH

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis

(2010) J. M. Spangle et al.   JOURNAL OF VIROLOGY

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

(2010) Shirish Shukla et al.   Molecular Cancer

Convergence between Wnt-β-catenin and EGFR signaling in cancer

(2010) Tianhui Hu et al.   Molecular Cancer

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation

(2010) S E Wheeler et al.   ONCOGENE

HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6-STAT3 Axis

(2010) E. Slinger et al.   Science Signaling

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

(2010) Jamel Mankouri et al.   PLoS Pathogens

Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration

(2009) Rozanne Arulanandam et al.   EXPERIMENTAL CELL RESEARCH

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation

(2009) L F Yap et al.   ONCOGENE

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

(2009) Cary A. Moody et al.   PLoS Pathogens

STAT3 can be activated through paracrine signaling in breast epithelial cells

(2008) Jacqueline C Lieblein et al.   BMC CANCER

Inactivation of the CYLD Deubiquitinase by HPV E6 Mediates Hypoxia-Induced NF-κB Activation

(2008) Jiabin An et al.   CANCER CELL

Human Papillomavirus Type 16/18 Up-Regulates the Expression of Interleukin-6 and Antiapoptotic Mcl-1 in Non-Small Cell Lung Cancer

(2008) Y.-W. Cheng et al.   CLINICAL CANCER RESEARCH

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor- B pathways in subtypes of diffuse large B-cell lymphoma

(2007) L. T. Lam et al.   BLOOD