PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis

Expert Views on HPV Infection

(2018) Alison McBride et al.   Viruses-Basel

Ectopic expression of the transcription factor MafB in basal keratinocytes induces hyperproliferation and perturbs epidermal homeostasis

(2017) Masashi Miyai et al.   EXPERIMENTAL DERMATOLOGY

Understanding the Molecular Genetics of Basal Cell Carcinoma

(2017) Cristina Pellegrini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The PTPN14 Tumor Suppressor Is a Degradation Target of Human Papillomavirus E7

(2017) Anita Szalmás et al.   JOURNAL OF VIROLOGY

Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes

(2017) Isha Sethi et al.   NUCLEIC ACIDS RESEARCH

Modulation of microRNA-mRNA Target Pairs by Human Papillomavirus 16 Oncoproteins

(2017) Mallory E. Harden et al.   mBio

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

(2017) Antonio Totaro et al.   Nature Communications

An oral keratinocyte life cycle model identifies novel host genome regulation by human papillomavirus 16 relevant to HPV positive head and neck cancer

(2017) Michael R. Evans et al.   Oncotarget

Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma

(2017) Tara J. Nulton et al.   Oncotarget

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states

(2017) Rachel Herndon Klein et al.   PLoS Genetics

Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation

(2016) Masashi Miyai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(2016) Ximena Bonilla et al.   NATURE GENETICS

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation

(2016) Elizabeth A. White et al.   mBio

Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney

(2016) R. Mehra et al.   Cancer Discovery

A LncRNA-MAF:MAFB Transcription Factor Network Regulates Epidermal Differentiation

(2015) Vanessa Lopez-Pajares et al.   DEVELOPMENTAL CELL

Epidemiology of Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma

(2015) Maura L. Gillison et al.   JOURNAL OF CLINICAL ONCOLOGY

Human Papillomavirus Carcinogenesis: an Identity Crisis in the Retinoblastoma Tumor Suppressor Pathway

(2015) Karl Munger et al.   JOURNAL OF VIROLOGY

Mutational dynamics between primary and relapse neuroblastomas

(2015) Alexander Schramm et al.   NATURE GENETICS

Human papillomavirus molecular biology and disease association

(2015) John Doorbar et al.   REVIEWS IN MEDICAL VIROLOGY

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

(2014) Julien Ablain et al.   INTERNATIONAL JOURNAL OF CANCER

PTPN14 Forms a Complex with Kibra and LATS1 Proteins and Negatively Regulates the YAP Oncogenic Function

(2014) Kayla E. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Papillomavirus E7 Proteins Associate with p190RhoGAP and Alter Its Function

(2014) B. Todorovic et al.   JOURNAL OF VIROLOGY

Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens

(2014) Elizabeth A. White et al.   JOURNAL OF VIROLOGY

Keratinocyte Detachment-Differentiation Connection Revisited, or Anoikis-Pityriasi Nexus Redux

(2014) Tomohiro Banno et al.   PLoS One

The Human Papillomavirus Type 8 E6 Protein Interferes with NOTCH Activation during Keratinocyte Differentiation

(2013) J. M. Meyers et al.   JOURNAL OF VIROLOGY

The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity

(2013) Chrysiis Michaloglou et al.   PLoS One

Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines

(2013) M. E. McLaughlin-Drubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The papillomavirus E7 proteins

(2013) Ann Roman et al.   VIROLOGY

Abstract 5418: α-Mangostin, a dietary xanthone, inhibits ectopic xenograft growth of pancreatic cancer cells in an athymic nude mice

(2012) Bilal B. Hafeez et al.   CANCER RESEARCH

Drosophila Pez Acts in Hippo Signaling to Restrict Intestinal Stem Cell Proliferation

(2012) Ingrid Poernbacher et al.   CURRENT BIOLOGY

PTPN14 is required for the density-dependent control of YAP1

(2012) W. Wang et al.   GENES & DEVELOPMENT

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity

(2012) E. A. White et al.   JOURNAL OF VIROLOGY

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

(2012) J-M Huang et al.   ONCOGENE

Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling

(2012) N Brimer et al.   ONCOGENE

PTPN14 interacts with and negatively regulates the oncogenic function of YAP

(2012) X Liu et al.   ONCOGENE

Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14

(2012) P Zhang et al.   ONCOGENE

Cutaneous  -human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling

(2012) M. J. A. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses

(2012) E. A. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia

(2012) Michael Benzinou et al.   Nature Communications

Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming

(2011) Margaret E. McLaughlin-Drubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Tyrosine Phosphatase PTPN14 Is a Regulator of Lymphatic Function and Choanal Development in Humans

(2010) Audrey C. Au et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis

(2008) Ingeborg Zehbe et al.   VIROLOGY