Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies

Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription

(2020) Claire D. James et al.   mSphere

Tocilizumab, an anti-interleukin-6 receptor antibody, efficiently ameliorates persistent joint inflammation in rheumatoid arthritis

(2020) Yasuhiko Hirabayashi   Modern Rheumatology

IL-23R in laryngeal cancer: a cancer immunoediting process that facilitates tumor cell proliferation and results in cisplatin resistance

(2020) Ye Tao et al.   CARCINOGENESIS

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

(2020) Ethan L. Morgan et al.   PLoS Pathogens

Randomized, Double-blind, Placebo-controlled, Multicenter Study of Siltuximab in High-risk Smoldering Multiple Myeloma

(2019) Timothy A Brighton et al.   CLINICAL CANCER RESEARCH

ADAM17-dependent signaling is required for oncogenic Human Papilloma virus entry platform assembly

(2019) Snježana Mikuličić et al.   eLife

Suppression of stromal interferon signaling by human papillomavirus type 16

(2019) Gaurav Raikhy et al.   JOURNAL OF VIROLOGY

The changing therapeutic landscape of head and neck cancer

(2019) John D. Cramer et al.   Nature Reviews Clinical Oncology

Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis

(2019) Ethan L. Morgan et al.   PLoS Pathogens

Correction for Evans et al., “Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle”

(2019) Michael R. Evans et al.   JOURNAL OF VIROLOGY

CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression

(2019) Joseph A. Westrich et al.   ONCOGENE

Level of phospho-STAT3 (Tyr705) correlates with copy number and physical state of human papillomavirus 16 genome in cervical precancer and cancer lesions

(2019) Shirish Shukla et al.   PLoS One

STAT3 and STAT5 Activation in Solid Cancers

(2019) Sebastian Igelmann et al.   Cancers

The Known and Potential Intersections of Rab-GTPases in Human Papillomavirus Infections

(2019) Jesse M. Young et al.   Frontiers in Cell and Developmental Biology

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

Human papillomavirus type 16 E5 inhibits interferon signaling and supports episomal viral maintenance

(2019) Matthew L. Scott et al.   JOURNAL OF VIROLOGY

ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

(2019) Schumacher et al.   Cancers

Targeting STAT3 in Cancer with Nucleotide Therapeutics

(2019) Yue-Ting K. Lau et al.   Cancers

JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death

(2019) Ethan L. Morgan et al.   Cancers

A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer and Systemic Inflammation

(2018) Giuseppe Giaccone et al.   Clinical Lung Cancer

HPV: Molecular pathways and targets

(2018) Shilpi Gupta et al.   CURRENT PROBLEMS IN CANCER

Sarilumab: A Review in Moderate to Severe Rheumatoid Arthritis

(2018) Yvette N. Lamb et al.   DRUGS

Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases

(2018) Susanna Nikolaus et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

ICTV Virus Taxonomy Profile: Papillomaviridae

(2018) Koenraad Van Doorslaer et al.   JOURNAL OF GENERAL VIROLOGY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

A First‐in‐Human Phase I Study of OPB‐111077, a Small‐Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers

(2018) Anthony Tolcher et al.   ONCOLOGIST

The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets

(2018) Karin Hoppe-Seyler et al.   TRENDS IN MICROBIOLOGY

Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma

(2018) Changhoon Yoo et al.   Cancer Research and Treatment

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

(2018) Ethan L. Morgan et al.   PLoS Pathogens

Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis

(2018) John Mascarenhas et al.   JAMA Oncology

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

(2018) Ryan D Ferrao et al.   eLife

“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway

(2018) Emira Bousoik et al.   Frontiers in Oncology

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

(2018) Matthew J. Reilley et al.   Journal for ImmunoTherapy of Cancer

Do STAT3 inhibitors have potential in the future for cancer therapy?

(2017) Andrea L.A. Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ruxolitinib for the treatment of inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): a randomised, open-label, phase 3b study

(2017) Francesco Passamonti et al.   LANCET ONCOLOGY

How Human Papillomavirus Replication and Immune Evasion Strategies Take Advantage of the Host DNA Damage Repair Machinery

(2017) Valentina Bordignon et al.   Viruses-Basel

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

(2017) Christopher W. Wasson et al.   Oncotarget

HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions

(2017) Nagayasu Egawa et al.   PLoS Pathogens

Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis

(2017) Christine M. Calton et al.   PLoS Pathogens

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry

(2017) Inci Aydin et al.   PLoS Pathogens

Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV + Patients

(2016) Toni M. Brand et al.   CLINICAL CANCER RESEARCH

STAT5 in Cancer and Immunity

(2016) Aradhana Rani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins

(2016) Matthew P. Bronnimann et al.   JOURNAL OF VIROLOGY

Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma

(2016) Jureeporn Chuerduangphui et al.   MEDICAL ONCOLOGY

KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8

(2016) W Zhang et al.   ONCOGENE

Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma

(2016) JIAN GAO et al.   ONCOLOGY REPORTS

Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14

(2016) Louis Cicchini et al.   mBio

Molecular mechanisms of cisplatin resistance in cervical cancer

(2016) Xueqiong Zhu et al.   Drug Design Development and Therapy

MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression

(2016) Z Fan et al.   Oncogenesis

Prognostic Impact of Epidermal Growth Factor Receptor Overexpression in Patients with Cervical Cancer: A Meta-Analysis

(2016) Wei-Jie Tian et al.   PLoS One

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

(2015) E. M. Dijkgraaf et al.   ANNALS OF ONCOLOGY

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma

(2015) Daria A. Gaykalova et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer

(2015) Freya A. Goumas et al.   INTERNATIONAL JOURNAL OF CANCER

Interaction of human papillomavirus type 16 particles with heparan sulfate and syndecan-1 molecules in the keratinocyte extracellular matrix plays an active role in infection

(2015) Zurab Surviladze et al.   JOURNAL OF GENERAL VIROLOGY

Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins

(2015) Christina Habiger et al.   JOURNAL OF VIROLOGY

Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis

(2015) Gauri Shishodia et al.   Molecular Cancer

Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia

(2015) Z. Liao et al.   MOLECULAR CANCER THERAPEUTICS

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

(2015) Lara Brambilla et al.   Molecular Oncology

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

(2015) David Hong et al.   Science Translational Medicine

Regulation of the Host Antiviral State by Intercellular Communications

(2015) Sonia Assil et al.   Viruses-Basel

Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins

(2015) Jesus Bello et al.   Viruses-Basel

STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication

(2015) Shiyuan Hong et al.   mBio

MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3

(2015) Zhongyi Fan et al.   Oncotarget

Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection

(2015) Andreea Popa et al.   PLoS Pathogens

JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth

(2015) Malabika Sen et al.   NEOPLASIA

Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein

(2015) Gauri Shishodia et al.   BMC CANCER

STAT4 Knockout Mice Are More Susceptible to Concanavalin A–Induced T-Cell Hepatitis

(2014) Yan Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-2 Enhances Cervical Cancer Cells Proliferation and JAK3/STAT5 Phosphorylation at Low Doses, While at High Doses IL-2 Has Opposite Effects

(2014) Arturo Valle-Mendiola et al.   CANCER INVESTIGATION

A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2014) E. Angevin et al.   CLINICAL CANCER RESEARCH

Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints

(2014) Valeria Orecchia et al.   EXPERIMENTAL DERMATOLOGY

PDZRN3/LNX3 Is a Novel Target of Human Papillomavirus Type 16 (HPV-16) and HPV-18 E6

(2014) Miranda Thomas et al.   JOURNAL OF VIROLOGY

E2 Proteins of High Risk Human Papillomaviruses Down-Modulate STING and IFN-κ Transcription in Keratinocytes

(2014) Nuchsupha Sunthamala et al.   PLoS One

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

(2014) P. J. Lupardus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

The Arrival of JAK Inhibitors: Advancing the Treatment of Immune and Hematologic Disorders

(2013) Yasuko Furumoto et al.   BIODRUGS

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

(2013) X. Zhang et al.   CANCER RESEARCH

Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment

(2013) Chunxia Ren et al.   EUROPEAN JOURNAL OF CANCER

Tetraspanin CD151 Mediates Papillomavirus Type 16 Endocytosis

(2013) K. D. Scheffer et al.   JOURNAL OF VIROLOGY

Functional Regulatory Role of STAT3 in HPV16-Mediated Cervical Carcinogenesis

(2013) Shirish Shukla et al.   PLoS One

HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures

(2013) E.-Y. Kho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus

(2013) A. Lipovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E4 protein; structure, function and patterns of expression

(2013) John Doorbar   VIROLOGY

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases

(2013) F Hayakawa et al.   Blood Cancer Journal

Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

(2013) Martina Niebler et al.   PLoS Pathogens

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

(2013) Jennifer M. Spangle et al.   PLoS Pathogens

The JAK-STAT Transcriptional Regulator, STAT-5, Activates the ATM DNA Damage Pathway to Induce HPV 31 Genome Amplification upon Epithelial Differentiation

(2013) Shiyuan Hong et al.   PLoS Pathogens

Reducing HPV-Associated Cancer Globally

(2012) D. R. Lowy et al.   Cancer Prevention Research

Inactivating All Three Rb Family Pocket Proteins Is Insufficient to Initiate Cervical Cancer

(2012) M.-K. Shin et al.   CANCER RESEARCH

Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer

(2012) M. Sen et al.   CLINICAL CANCER RESEARCH

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

(2012) Z. Surviladze et al.   JOURNAL OF VIROLOGY

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Entry of Human Papillomavirus Type 16 by Actin-Dependent, Clathrin- and Lipid Raft-Independent Endocytosis

(2012) Mario Schelhaas et al.   PLoS Pathogens

Essential Roles for Soluble Virion-Associated Heparan Sulfonated Proteoglycans and Growth Factors in Human Papillomavirus Infections

(2012) Zurab Surviladze et al.   PLoS Pathogens

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

(2011) E. A. Nelson et al.   BLOOD

Early Tumor Progression Associated with Enhanced EGFR Signaling with Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer

(2011) A. Argiris et al.   CLINICAL CANCER RESEARCH

Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness

(2011) David M Winder et al.   JOURNAL OF PATHOLOGY

Suppression of STAT-1 Expression by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification and Plasmid Maintenance

(2011) S. Hong et al.   JOURNAL OF VIROLOGY

High-Risk Human Papillomaviruses Repress Constitutive Kappa Interferon Transcription via E6 To Prevent Pathogen Recognition Receptor and Antiviral-Gene Expression

(2011) J. Reiser et al.   JOURNAL OF VIROLOGY

Papillomavirus E5: the smallest oncoprotein with many functions

(2011) Aldo Venuti et al.   Molecular Cancer

IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway

(2011) A. Yadav et al.   MOLECULAR CANCER RESEARCH

A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer

(2010) J-F Rossi et al.   BRITISH JOURNAL OF CANCER

A Role for HPV16 E5 in Cervical Carcinogenesis

(2010) John P. Maufort et al.   CANCER RESEARCH

Targeted Blockage of Signal Transducer and Activator of Transcription 5 Signaling Pathway with Decoy Oligodeoxynucleotides Suppresses Leukemic K562 Cell Growth

(2010) Xiaozhong Wang et al.   DNA AND CELL BIOLOGY

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

(2010) C. J. Greenhill et al.   JOURNAL OF IMMUNOLOGY

Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor

(2010) Ken Miyoshi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV

(2010) S. Miura et al.   JOURNAL OF VIROLOGY

IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes

(2010) Correne A DeCarlo et al.   LABORATORY INVESTIGATION

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

(2010) Shirish Shukla et al.   Molecular Cancer

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Usage of heparan sulfate, integrins, and FAK in HPV16 infection

(2010) Cynthia Y. Abban et al.   VIROLOGY

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

(2010) Xiaomei Ren et al.   ACS Medicinal Chemistry Letters

Epigenetic Silencing of Interferon-  in Human Papillomavirus Type 16-Positive Cells

(2009) B. Rincon-Orozco et al.   CANCER RESEARCH

Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway

(2009) A C Hoover et al.   ONCOGENE

Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies

(2009) Jacqueline Sayyah et al.   Current Oncology Reports

Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

(2009) Cary A. Moody et al.   PLoS Pathogens

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH

Constitutive Activation of Signal Transducer and Activator of Transcription 5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition, and Resistance to Epidermal Growth Factor Receptor Targeting

(2008) P. Koppikar et al.   CLINICAL CANCER RESEARCH

Arrangement of L2 within the Papillomavirus Capsid

(2008) C. B. Buck et al.   JOURNAL OF VIROLOGY

Heparan Sulfate-Independent Cell Binding and Infection with Furin-Precleaved Papillomavirus Capsids

(2008) P. M. Day et al.   JOURNAL OF VIROLOGY

Human papillomaviruses, cervical cancer and cell polarity

(2008) M Thomas et al.   ONCOGENE

Virus activated filopodia promote human papillomavirus type 31 uptake from the extracellular matrix

(2008) Jessica L. Smith et al.   VIROLOGY

The human papillomavirus E7 oncoprotein

(2008) Margaret E. McLaughlin-Drubin et al.   VIROLOGY

Human Papillomavirus Type 16 Entry: Retrograde Cell Surface Transport along Actin-Rich Protrusions

(2008) Mario Schelhaas et al.   PLoS Pathogens