E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

(2020) Shannon Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

(2020) Ethan L. Morgan et al.   PLoS Pathogens

TCPA v3.0: An Integrative Platform to Explore the Pan-cancer Analysis of Functional Proteomic Data

(2019) Mei-Ju May Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis

(2019) Ethan L. Morgan et al.   PLoS Pathogens

HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer

(2019) Sayuri Miyauchi et al.   CANCER RESEARCH

JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death

(2019) Ethan L. Morgan et al.   Cancers

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

(2018) Ethan L. Morgan et al.   PLoS Pathogens

The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation

(2018) Nomeda Girnius et al.   eLife

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5

(2018) Laura F. Wetherill et al.   ANTIVIRAL RESEARCH

Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

(2018) Ieisha Pentland et al.   PLOS BIOLOGY

The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

(2017) Christopher W. Wasson et al.   Oncotarget

HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions

(2017) Nagayasu Egawa et al.   PLoS Pathogens

Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV + Patients

(2016) Toni M. Brand et al.   CLINICAL CANCER RESEARCH

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

(2016) X Xie et al.   ONCOGENE

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis

(2016) Donia Mili et al.   Molecular Cytogenetics

A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor

(2016) Mojgan Padash Barmchi et al.   PLoS Pathogens

Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach

(2016) Sophie Schumann et al.   Nature Microbiology

EMT in cervical cancer: Its role in tumour progression and response to therapy

(2015) Rehana Qureshi et al.   CANCER LETTERS

JNK-dependent gene regulatory circuitry governs mesenchymal fate

(2015) S. K. Sahu et al.   EMBO JOURNAL

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins

(2015) Jesus Bello et al.   Viruses-Basel

HPV16 E5 and KGFR/FGFR2b interplay in differentiating epithelial cells

(2015) Valeria Purpura et al.   Oncotarget

A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition

(2014) Yong Fang et al.   BIOCHEMICAL JOURNAL

p38MAPK and MK2 Pathways Are Important for the Differentiation-Dependent Human Papillomavirus Life Cycle

(2014) Ayano Satsuka et al.   JOURNAL OF VIROLOGY

IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples

(2014) Frency Varghese et al.   PLoS One

Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells

(2014) Erying Zhang et al.   PLoS One

The Role of Protein Kinase A Regulation of the E6 PDZ-Binding Domain during the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 18

(2013) C. P. Delury et al.   JOURNAL OF VIROLOGY

Human papillomavirus and cervical cancer

(2013) Emma J Crosbie et al.   LANCET

HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures

(2013) E.-Y. Kho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

(2013) Jennifer M. Spangle et al.   PLoS Pathogens

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

(2011) C. Cellurale et al.   MOLECULAR AND CELLULAR BIOLOGY

Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

(2011) Sutapa Mahata et al.   Molecular Cancer

A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK–cyclin complexes and G2/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L1 capsid protein expression

(2011) Gillian L. Knight et al.   VIROLOGY

Jun and JunD-dependent functions in cell proliferation and stress response

(2010) A Meixner et al.   CELL DEATH AND DIFFERENTIATION

JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis

(2009) Dong-Oh Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF- 1

(2008) J. F. Alcorn et al.   JOURNAL OF CELL SCIENCE

Reducing Uncertainties About the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 18 Randomized Trials

(2008)   JOURNAL OF CLINICAL ONCOLOGY

Human papillomaviruses, cervical cancer and cell polarity

(2008) M Thomas et al.   ONCOGENE

E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway

(2008) Adriana Contreras-Paredes et al.   VIROLOGY