Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

Human papillomavirus E5 oncoprotein: function and potential target for antiviral therapeutics

(2015) Marietta Müller et al.   Future Virology

Viroporins: structure, function and potential as antiviral targets

(2015) Claire Scott et al.   JOURNAL OF GENERAL VIROLOGY

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein

(2015) Da Ao et al.   PLoS One

Response of host inflammasomes to viral infection

(2015) I-Yin Chen et al.   TRENDS IN MICROBIOLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

NLRP3 Inflammasome Activation by Viroporins of Animal Viruses

(2015) Hui-Chen Guo et al.   Viruses-Basel

Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin

(2015) Vanesa Madan et al.   Viruses-Basel

Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?

(2015) Jaume Torres et al.   Viruses-Basel

YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins

(2015) Marietta Müller et al.   Scientific Reports

Anion homeostasis is important for non-lytic release of BK polyomavirus from infected cells

(2015) Gareth L. Evans et al.   Open Biology

Nuclear Magnetic Resonance Structure Revealed that the Human Polyomavirus JC Virus Agnoprotein Contains an  -Helix Encompassing the Leu/Ile/Phe-Rich Domain

(2014) P. Coric et al.   JOURNAL OF VIROLOGY

Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment

(2014) Y. Li et al.   JOURNAL OF VIROLOGY

Two Different Conformations in Hepatitis C Virus p7 Protein Account for Proton Transport and Dye Release

(2014) Siok Wan Gan et al.   PLoS One

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

(2014) Jose L. Nieto-Torres et al.   PLoS Pathogens

Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus

(2014) Gabrielė Stakaitytė et al.   Cancers

The human JC polyomavirus (JCPyV): virological background and clinical implications

(2013) Hans H. Hirsch et al.   APMIS

Viroporin-mediated calcium-activated autophagy

(2013) Sue E. Crawford et al.   Autophagy

SV40 Late Protein VP4 Forms Toroidal Pores To Disrupt Membranes for Viral Release

(2013) Smita Raghava et al.   BIOCHEMISTRY

The minimalist architectures of viroporins and their therapeutic implications

(2013) Bo OuYang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

(2013) Toshana L. Foster et al.   HEPATOLOGY

Unusual architecture of the p7 channel from hepatitis C virus

(2013) Bo OuYang et al.   NATURE

A cornucopia of human polyomaviruses

(2013) James A. DeCaprio et al.   NATURE REVIEWS MICROBIOLOGY

Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3

(2013) T. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential roles of Leu/Ile/Phe-rich domain of JC virus agnoprotein in dimer/oligomer formation, protein stability and splicing of viral transcripts

(2013) A. Sami Saribas et al.   VIROLOGY

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences

(2013) Elizabeth Atkins et al.   VIROLOGY

The Rapidly Expanding Family of Human Polyomaviruses: Recent Developments in Understanding Their Life Cycle and Role in Human Pathology

(2013) Martyn K. White et al.   PLoS Pathogens

The Small Hydrophobic Protein of the Human Respiratory Syncytial Virus Forms Pentameric Ion Channels

(2012) Siok-Wan Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viroporin Activity of the Minor Structural Proteins VP2 and VP3 Is Required for SV40 Propagation

(2012) Kristina M. Giorda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Simian Virus 40 Late Viral Protein VP4 Disrupts the Nuclear Envelope for Viral Release

(2012) K. M. Giorda et al.   JOURNAL OF VIROLOGY

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine

(2012) D. P. Gladue et al.   JOURNAL OF VIROLOGY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-  signaling is required for rotavirus replication

(2012) S. E. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agnoprotein of mammalian polyomaviruses

(2012) Nancy Gerits et al.   VIROLOGY

Virion Assembly Factories in the Nucleus of Polyomavirus-Infected Cells

(2012) Kimberly D. Erickson et al.   PLoS Pathogens

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

(2011) Toshana L. Foster et al.   HEPATOLOGY

Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content

(2011) Ilker K Sariyer et al.   Virology Journal

The SV40 Late Protein VP4 Is a Viroporin that Forms Pores to Disrupt Membranes for Viral Release

(2011) Smita Raghava et al.   PLoS Pathogens

A Role for HPV16 E5 in Cervical Carcinogenesis

(2010) John P. Maufort et al.   CANCER RESEARCH

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

(2010) Stephen D. Carter et al.   FEBS LETTERS

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

(2010) Chen S Tan et al.   LANCET NEUROLOGY

Progressive multifocal leukoencephalopathy and other forms of JC virus disease

(2010) Bruce J. Brew et al.   Nature Reviews Neurology

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments

(2010) Hans-Ulrich Bernard et al.   VIROLOGY

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

(2010) J. M. Hyser et al.   mBio

Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production

(2010) Ann L. Wozniak et al.   PLoS Pathogens

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

(2010) Tadaki Suzuki et al.   PLoS Pathogens

Membrane Orientation of the Human Papillomavirus Type 16 E5 Oncoprotein

(2009) E. Krawczyk et al.   JOURNAL OF VIROLOGY

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

(2009) C. StGelais et al.   JOURNAL OF VIROLOGY

JC Virus: An oncogenic virus in animals and humans?

(2009) Melissa S. Maginnis et al.   SEMINARS IN CANCER BIOLOGY

Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell–cell fusion

(2009) Lulin Hu et al.   VIROLOGY

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

(2009) Konstantin Pervushin et al.   PLoS Pathogens

Koilocytosis

(2008) Ewa Krawczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

Karyopherin β3: A new cellular target for the HPV-16 E5 oncoprotein

(2008) Ewa Krawczyk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein

(2008) J. A. Regan et al.   JOURNAL OF VIROLOGY

An siRNA against JC virus (JCV) agnoprotein inhibits JCV infection in JCV-producing cells inoculated in nude mice

(2008) Tomoko Matoba et al.   NEUROPATHOLOGY

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE

Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: Inhibition by small t antigen

(2008) Ilker K. Sariyer et al.   VIROLOGY