Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases

Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications

(2020) Dawit Zewdu Wondafrash et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Epigenetic regulation of insulin action and secretion – role in the pathogenesis of type 2 diabetes

(2020) C. Ling   JOURNAL OF INTERNAL MEDICINE

Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas

(2020) Anqi Yao et al.   MOLECULAR NEUROBIOLOGY

Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling

(2020) Qiong Pan et al.   NEUROCHEMISTRY INTERNATIONAL

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

(2020) Yifan Jia et al.   Redox Biology

Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer

(2020) Ming Xie et al.   CELL BIOLOGY INTERNATIONAL

Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-Induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model

(2020) Islam N. Mohamed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent

(2020) Marianna M.S. Beyer et al.   JOURNAL OF NEUROSCIENCE

Glucose transporters in brain in health and disease

(2020) Hermann Koepsell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status

(2020) Che‐Yuan Wu et al.   Alzheimers & Dementia

GW0742 activates miR‐17‐5p and inhibits TXNIP/NLRP3‐mediated inflammation after hypoxic‐ischaemic injury in rats and in PC12 cells

(2020) Marcin Gamdzyk et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alzheimer’s disease and type 2 diabetes mellitus: A systematic review of proteomic studies

(2020) Jessica Diniz Pereira et al.   JOURNAL OF NEUROCHEMISTRY

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

(2020) Ranjithmenon Muraleedharan et al.   Cell Reports

Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

(2020) Aleksandra Gasecka et al.   Journal of Clinical Medicine

Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy

(2020) Ana Karen López-Contreras et al.   Antioxidants

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

(2020) Nur Zuliani Ramli et al.   Antioxidants

Defective mitophagy in Alzheimer’s disease

(2020) Jangampalli Adi Pradeepkiran et al.   AGEING RESEARCH REVIEWS

Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway

(2020) Jean Baptiste Nyandwi et al.   BIOCHEMICAL PHARMACOLOGY

Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation

(2020) Rui Ding et al.   NEUROCHEMISTRY INTERNATIONAL

Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin

(2019) Anarmaa Mendsaikhan et al.   Frontiers in Molecular Neuroscience

Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer’s Disease Brain

(2019) Lexiao Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

(2019) Yurika Katsu-Jiménez et al.   DIABETES

Cognitive Decline, Cerebral-Spleen Tryptophan Metabolism, Oxidative Stress, Cytokine Production, and Regulation of the Txnip Gene in 3xTg-AD Mice

(2019) Emre Fertan et al.   AMERICAN JOURNAL OF PATHOLOGY

TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells

(2019) Takhellambam S. Devi et al.   Biology Open

Effect of metformin on neurodegenerative disease among elderly adult US veterans with type 2 diabetes mellitus

(2019) Qian Shi et al.   BMJ Open

Resveratrol Suppresses Aβ-Induced Microglial Activation Through the TXNIP/TRX/NLRP3 Signaling Pathway

(2019) Lifang Feng et al.   DNA AND CELL BIOLOGY

Curcumin relieves paraquat‑induced lung injury through inhibiting the thioredoxin interacting protein/NLR pyrin domain containing 3‑mediated inflammatory pathway

(2019) Yi Ren et al.   Molecular Medicine Reports

Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice

(2019) Ge Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative stress-mediated TXNIP loss causes RPE dysfunction

(2019) Min Ji Cho et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Upregulation of Thioredoxin-Interacting Protein in Brain of Amyloid-β Protein Precursor/Presenilin 1 Transgenic Mice and Amyloid-β Treated Neuronal Cells

(2019) Yiran Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

(2019) Asta Lučiūnaitė et al.   JOURNAL OF NEUROCHEMISTRY

Silencing of TXNIP Alleviated Oxidative Stress Injury by Regulating MAPK–Nrf2 Axis in Ischemic Stroke

(2019) Yu Tian et al.   NEUROCHEMICAL RESEARCH

Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia

(2019) Veni Bharti et al.   NEUROCHEMISTRY INTERNATIONAL

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)2D3: Is It Really the Vitamin D3 Upregulated Protein?

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases

(2018) Jianghua Hu et al.   Oxidative Medicine and Cellular Longevity

Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway

(2018) Mariarosa Anna. Beatrice Melone et al.   PHARMACEUTICAL RESEARCH

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action

(2018) Karthik Nagaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined treatment with D-allose, docetaxel and radiation inhibits the tumor growth in an in�vivo model of head and neck cancer

(2018) Hiroshi Hoshikawa et al.   Oncology Letters

Alteration of Thioredoxin and Glutaredoxin in the Progression of Alzheimer's Disease

(2018) Lisa Arodin et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats

(2018) Marcin Gamdzyk et al.   NEUROPHARMACOLOGY

Inhibition of nuclear thioredoxin aggregation attenuates PM2.5-induced NF-κB activation and pro-inflammatory responses

(2018) Zhonghui Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased thioredoxin-interacting protein in brain of mice exposed to chronic stress

(2018) Hong Zhou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Thioredoxin-1, redox factor-1 and thioredoxin-interacting protein, mRNAs are differentially expressed in Multiple Sclerosis patients exposed and non-exposed to interferon and immunosuppressive treatments

(2017) Elham Mahmoudian et al.   GENE

Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons

(2017) Sabrina M Heman-Ackah et al.   HUMAN MOLECULAR GENETICS

Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage

(2017) Qing Zhao et al.   Journal of Neuroinflammation

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

A novel indication of thioredoxin-interacting protein as a tumor suppressor gene in malignant glioma

(2017) Pengxing Zhang et al.   Oncology Letters

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

(2017) Beibei Luo et al.   Frontiers in Physiology

Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia

(2017) Saisudha Koka et al.   Redox Biology

Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle

(2016) Ashok Mandala et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease

(2016) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

(2016) Ren-Hong Du et al.   Redox Biology

Alterations of the thioredoxin system during subarachnoid hemorrhage-induced cerebral vasospasm

(2015) B. Kaya et al.   ACTA NEUROCHIRURGICA

Fenofibrate suppressed proliferation and migration of human neuroblastoma cells via oxidative stress dependent of TXNIP upregulation

(2015) Cunjin Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy

(2015) A. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

(2015) Pan Gao et al.   Journal of Diabetes Research

In vitro and in vivo Effects of D-Allose: Up-Regulation of Thioredoxin-Interacting Protein in Head and Neck Cancer Cells

(2014) Hiroshi Hoshikawa et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Thioredoxin-Interacting Protein: Pathophysiology and Emerging Pharmacotherapeutics in Cardiovascular Disease and Diabetes

(2014) Cher-Rin Chong et al.   CARDIOVASCULAR DRUGS AND THERAPY

Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1

(2014) Fuminori Yamaguchi et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer

(2014) Jennifer A Morrison et al.   Molecular Cancer

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells

(2014) Yan Luo et al.   PLoS One

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

(2014) Liang-Jun Yan   Journal of Diabetes Research

TXNIP interacts with hEcd to increase p53 stability and activity

(2013) Hyun-Woo Suh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Alzheimer’s Disease Neuropathology is Associated with Type 2 Diabetes and ApoE ε4 Carrier Status

(2013) Michael Malek-Ahmadi et al.   Current Alzheimer Research

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

(2013) Islam N. Mohamed et al.   DIABETOLOGIA

Induction of the Metabolic Regulator Txnip in Fasting-Induced and Natural Torpor

(2013) Laura E. Hand et al.   ENDOCRINOLOGY

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy

(2013) Takhellambam S. Devi et al.   EXPERIMENTAL CELL RESEARCH

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Thioredoxin-Interacting Protein Gene Expression via MondoA Is Rapidly and Transiently Suppressed during Inflammatory Responses

(2013) Yasuyoshi Kanari et al.   PLoS One

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

(2013) Young-Jun Park et al.   PLoS Pathogens

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

TXNIP in Agrp Neurons Regulates Adiposity, Energy Expenditure, and Central Leptin Sensitivity

(2012) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Deficiency of Thioredoxin Binding Protein-2 (TBP-2) Enhances TGF-β Signaling and Promotes Epithelial to Mesenchymal Transition

(2012) So Masaki et al.   PLoS One

Thioredoxin-interacting protein suppresses bladder carcinogenesis

(2011) Koji Nishizawa et al.   CARCINOGENESIS

Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells

(2011) Yonghong Shi et al.   FEBS LETTERS

MondoA Senses Non-glucose Sugars

(2011) Carrie A. Stoltzman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice

(2011) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

(2011) Maayan Shaked et al.   PLoS One

The Emerging Role of the Thioredoxin System in Angiogenesis

(2010) Louise L. Dunn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of endothelial cell proliferation on atherogenesis: A role of p21Sdi/Cip/Waf1 in monocyte adhesion to endothelial cells

(2010) Hiyo Obikane et al.   ATHEROSCLEROSIS

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin and glutaredoxin system proteins—immunolocalization in the rat central nervous system

(2010) Maria Laura Aon-Bertolino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Flexible ligand recognition of peroxisome proliferator-activated receptor-γ (PPARγ)

(2010) Kenji Yamagishi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression

(2010) Marc-Andre Martel et al.   Channels

Deletion of the  -Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

(2010) W. A. Chutkow et al.   DIABETES

p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells

(2010) Yunzhuo Ren et al.   FEBS LETTERS

Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity

(2010) Michael R. Farrell et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Retinal Pigment Epithelium: Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy

(2010) Rafael Simó et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion

(2010) O. Sbai et al.   JOURNAL OF CELL SCIENCE

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Transcription Factors Krüppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-γ Mediate High Glucose-Induced Thioredoxin-Interacting Protein

(2009) Weier Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein

(2009) Junqin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thioredoxin Binding Protein 2 Modulates Natural Killer T Cell-Dependent Innate Immunity in the Liver: Possible Link to Lipid Metabolism

(2009) Hiroaki Okuyama et al.   ANTIOXIDANTS & REDOX SIGNALING

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets

(2009) M. Shaked et al.   DIABETOLOGIA

Thioredoxin-independent Regulation of Metabolism by the α-Arrestin Proteins

(2009) Parth Patwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the inhibitory mechanism of d-allose on MOLT-4F leukemia cell proliferation

(2009) Yuko Hirata et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

(2009) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression and regulation of vitamin D3upregulated protein 1 (VDUP1) is conserved in mammalian and insect brain

(2009) Mark C. Levendusky et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Adenosine-Containing Molecules Amplify Glucose Signaling and Enhance Txnip Expression

(2009) Fa-Xing Yu et al.   MOLECULAR ENDOCRINOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Tandem ChoRE and CCAAT Motifs and Associated Factors Regulate Txnip Expression in Response to Glucose or Adenosine-Containing Molecules

(2009) Fa-Xing Yu et al.   PLoS One

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function

(2008) Shin-ichi Oka et al.   ENDOCRINOLOGY

Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses

(2008) Aoi Son et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rare sugar d-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7

(2008) Fuminori Yamaguchi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Thioredoxin-1 and Its Natural Inhibitor, Vitamin D3 Up-Regulated Protein 1, Are Differentially Regulated by PPARα in Human Macrophages

(2008) Ludivine Billiet et al.   JOURNAL OF MOLECULAR BIOLOGY