TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells

Mechanisms, pathophysiological roles and methods for analyzing mitophagy – recent insights

(2018) Jessica A. Williams et al.   BIOLOGICAL CHEMISTRY

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Neurodegeneration in diabetic retinopathy: does it really matter?

(2018) Rafael Simó et al.   DIABETOLOGIA

Therapeutic targets for altering mitochondrial dysfunction associated with diabetic retinopathy

(2018) Renu A. Kowluru et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

(2018) Rahul Mittal et al.   Frontiers in Genetics

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima

(2017) Nuo Sun et al.   Nature Protocols

Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes

(2017) Xian-Yong Zhou et al.   Cell Death & Disease

TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy

(2017) Takhellambam Swornalata Devi et al.   Cell Death & Disease

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

(2017) Althea N. Waldhart et al.   Cell Reports

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

Mitochondrial contribution to lipofuscin formation

(2017) Jeannette König et al.   Redox Biology

Increase of transcription factor EB (TFEB) and lysosomes in rat DRG neurons and their transportation to the central nerve terminal in dorsal horn after nerve injury

(2016) J. Jung et al.   NEUROSCIENCE

Significance of optineurin mutations in glaucoma and other diseases

(2016) Yuriko Minegishi et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Diabetic retinopathy

(2016) Tien Y. Wong et al.   Nature Reviews Disease Primers

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

(2015) Anastasia G. Henry et al.   HUMAN MOLECULAR GENETICS

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Protecting the mitochondrial powerhouse

(2015) Morten Scheibye-Knudsen et al.   TRENDS IN CELL BIOLOGY

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment

(2014) Steven F. Abcouwer et al.   Annals of the New York Academy of Sciences

Understanding photoreceptor outer segment phagocytosis: Use and utility of RPE cells in culture

(2014) Francesca Mazzoni et al.   EXPERIMENTAL EYE RESEARCH

Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases

(2014) Faraz Ahmad et al.   FREE RADICAL BIOLOGY AND MEDICINE

MondoA-Mlx Transcriptional Activity Is Limited by mTOR-MondoA Interaction

(2014) Mohan R. Kaadige et al.   MOLECULAR AND CELLULAR BIOLOGY

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy

(2013) Takhellambam S. Devi et al.   EXPERIMENTAL CELL RESEARCH

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

(2013) Y. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Iron, Iron Chelation, and Cell Death

(2012) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

The Enlarged Lysosomes in beigej Cells Result From Decreased Lysosome Fission and Not Increased Lysosome Fusion

(2011) Nina Durchfort et al.   TRAFFIC

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

(2010) C. A. Aveleira et al.   DIABETES

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

The Retinal Pigment Epithelium: Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy

(2010) Rafael Simó et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy

(2010) L Perrone et al.   Cell Death & Disease

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

(2009) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY