标题
Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
作者
关键词
-
出版物
Antioxidants
Volume 9, Issue 9, Pages 865
出版商
MDPI AG
发表日期
2020-09-15
DOI
10.3390/antiox9090865
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Health benefits of fucoxanthin in the prevention of chronic diseases
- (2020) Minkyung Bae et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress
- (2020) Milad Ashrafizadeh et al. LIFE SCIENCES
- Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols
- (2020) Chung S. Yang et al. MOLECULAR CARCINOGENESIS
- MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?
- (2020) Hossein Rafiei et al. PHYTOTHERAPY RESEARCH
- Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway
- (2020) Youming Chen et al. Aging-US
- 3,3-Diindolylmethane (DIM): A nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial
- (2020) Rinat Yerushalmi et al. CARCINOGENESIS
- Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury
- (2020) Tian-Xin Zhao et al. ENVIRONMENTAL POLLUTION
- Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer
- (2020) Jong-Su Kang et al. BIOCHEMICAL PHARMACOLOGY
- Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
- (2020) Meiling Gong et al. Cell Communication and Signaling
- Emerging crosstalk between long non-coding RNAs and Nrf2 signaling
- (2020) Shamee Bhattacharjee et al. CANCER LETTERS
- Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition
- (2019) Praveen Rajendran et al. CANCER RESEARCH
- Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
- (2019) Helai P. Mohammad et al. NATURE MEDICINE
- Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer
- (2019) Linbo Gao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes
- (2019) Yao Zhu et al. ATHEROSCLEROSIS
- Luteolin, a flavonoid, as an anticancer agent: A review
- (2019) Muhammad Imran et al. BIOMEDICINE & PHARMACOTHERAPY
- Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- (2019) Kyoung Ah Kang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Nrf2 in cancers: A double‐edged sword
- (2019) Shijia Wu et al. Cancer Medicine
- Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway
- (2019) Hsiao-Chen Dina Kuo et al. AAPS Journal
- Pelargonidin reduces the TPA induced transformation of mouse epidermal cells –potential involvement of Nrf2 promoter demethylation
- (2019) Shanyi Li et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2
- (2019) Yujie Yang et al. LIVER INTERNATIONAL
- Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
- (2019) Yoko Yagishita et al. MOLECULES
- Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease
- (2019) Christine A. Houghton Oxidative Medicine and Cellular Longevity
- Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1
- (2019) Jesse R. Poganik et al. FASEB JOURNAL
- Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway
- (2019) Hossein Hosseini et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The timeline of epigenetic drug discovery: from reality to dreams
- (2019) A. Ganesan et al. Clinical Epigenetics
- Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells
- (2018) Yuqing Yang et al. AAPS Journal
- BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors
- (2018) Nirmalya Chatterjee et al. BIOESSAYS
- Apigenin: A dietary flavonoid with diverse anticancer properties
- (2018) Josip Madunić et al. CANCER LETTERS
- Vitamin E and its anticancer effects
- (2018) Annette Abraham et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- MiR-455-3p activates Nrf2/ARE signaling via HDAC2 and protects osteoblasts from oxidative stress
- (2018) Shijun Zhang et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells
- (2018) Linbo Gao et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells
- (2018) Jie Yang et al. MOLECULAR CARCINOGENESIS
- Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells
- (2018) Chao Wang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs
- (2018) F. P. Fabrizio et al. Oxidative Medicine and Cellular Longevity
- Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
- (2018) Xuling Su et al. Oxidative Medicine and Cellular Longevity
- Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
- (2018) Xiao-Juan Zhao et al. Redox Biology
- Modulating NRF2 in Disease: Timing Is Everything
- (2018) Matthew Dodson et al. Annual Review of Pharmacology and Toxicology
- The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells
- (2018) Qian Zuo et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets
- (2018) Marina Montagnani Marelli et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Diet and the epigenome
- (2018) Yi Zhang et al. Nature Communications
- Sabotaging of the oxidative stress response by an oncogenic noncoding RNA
- (2017) Nitin Mahajan et al. FASEB JOURNAL
- Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications
- (2017) Haixue Kuang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer
- (2017) Laura M. Beaver et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1
- (2017) Burak Akdemir et al. MOLECULAR CANCER RESEARCH
- A functional pseudogene,NMRAL2P, is regulated by Nrf2 and serves as a coactivator ofNQO1in sulforaphane-treated colon cancer cells
- (2017) Gavin S. Johnson et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes
- (2017) Chengyue Zhang et al. MOLECULAR PHARMACEUTICS
- DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
- (2017) David Brocks et al. NATURE GENETICS
- Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway
- (2017) Ai-Mei Gao et al. Oncotarget
- Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma
- (2017) Federico Pio Fabrizio et al. Oncotarget
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway
- (2016) Bo Hong et al. AAPS Journal
- MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer
- (2016) B. Zhang et al. CURRENT MOLECULAR MEDICINE
- Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression
- (2016) Tsui-Hwa Tseng et al. ENVIRONMENTAL TOXICOLOGY
- Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells
- (2016) Hyuck Kim et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- The bounty of nature for changing the cancer landscape
- (2016) Aamir Ahmad et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg
- (2016) Naomi Fujioka et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- (2016) Michael S. Bonkowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
- (2016) Leonard D. Goldstein et al. Cell Reports
- Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention
- (2015) Bryan Harder et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- NRF2 and microRNAs: new but awaited relations
- (2015) Svitlana Kurinna et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Taxifolin curbs NF-κB-mediated Wnt/β-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis
- (2015) Krishnan Manigandan et al. BIOCHIMIE
- Z-ligustilide ameliorated ultraviolet B-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO-1 and suppression of NF-κB pathway
- (2015) Zhouwei Wu et al. EXPERIMENTAL DERMATOLOGY
- MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
- (2015) Savan Kabaria et al. FREE RADICAL BIOLOGY AND MEDICINE
- Epigenetic regulation of Keap1-Nrf2 signaling
- (2015) Yue Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells
- (2015) Kaipeng Huang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components
- (2015) Christina DiMarco-Crook et al. Annual Review of Food Science and Technology
- Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon
- (2015) Praveen Rajendran et al. Clinical Epigenetics
- Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway
- (2014) Ling Wang et al. AAPS Journal
- Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications
- (2014) Ximena Paredes-Gonzalez et al. AAPS Journal
- Epigenetic DNA Methylation of Antioxidative Stress Regulator NRF2 in Human Prostate Cancer
- (2014) T. O. Khor et al. Cancer Prevention Research
- Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways
- (2014) Bhupendra Singh et al. CARCINOGENESIS
- The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2
- (2014) Ziming Li et al. FEBS LETTERS
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
- (2014) T. Wu et al. GENES & DEVELOPMENT
- Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells
- (2014) Carmen P. Wong et al. PLoS One
- The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response
- (2014) M Hussong et al. Cell Death & Disease
- Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Plant-Derived Compounds and Trace Minerals
- (2014) Amanda Stefanson et al. Nutrients
- Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors
- (2013) Tien-Yuan Wu et al. AAPS Journal
- Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia–reperfusion injury in vivo and in vitro
- (2013) Bin Peng et al. BRAIN RESEARCH
- Epigenetic Reactivation of Nrf2 in Murine Prostate Cancer TRAMP C1 Cells by Natural Phytochemicals Z-Ligustilide and Radix Angelica Sinensis via Promoter CpG Demethylation
- (2013) Zheng-Yuan Su et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
- (2013) Clarissa Gerhauser CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling
- (2013) N. Wakabayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane
- (2013) Lyndsey E. Shorey et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells
- (2012) Duo Guo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance
- (2012) S. A. Rushworth et al. BLOOD
- AberrantKeap1methylation in breast cancer and association with clinicopathological features
- (2012) Raffaela Barbano et al. Epigenetics
- A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation
- (2012) Ying Huang et al. JOURNAL OF NUTRITION
- miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells
- (2012) M T M van Jaarsveld et al. ONCOGENE
- 3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells
- (2012) Laura M. Beaver et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Dietary Factors and Epigenetic Regulation for Prostate Cancer Prevention
- (2012) Emily Ho et al. Advances in Nutrition
- Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
- (2011) Nicolas Mercado et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation
- (2011) Tin Oo Khor et al. BIOCHEMICAL PHARMACOLOGY
- Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome
- (2011) Lucia Anna Muscarella et al. Epigenetics
- Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
- (2011) Lucia Anna Muscarella et al. Epigenetics
- miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells
- (2011) Gabriel Eades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study
- (2011) Mitali Pandey et al. MOLECULAR CARCINOGENESIS
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
- (2011) Anna Hsu et al. Clinical Epigenetics
- Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
- (2010) L. M. Solis et al. CLINICAL CANCER RESEARCH
- Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice
- (2010) Siwang Yu et al. PLoS One
- Cancer-preventive activities of tocopherols and tocotrienols
- (2009) Jihyeung Ju et al. CARCINOGENESIS
- Nrf2: friend or foe for chemoprevention?
- (2009) T. W. Kensler et al. CARCINOGENESIS
- Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds
- (2009) Hui Nian et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
- (2009) Z. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting NRF2 signaling for cancer chemoprevention
- (2009) Mi-Kyoung Kwak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
- (2008) Guang-Hui Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Multi-targeted prevention of cancer by sulforaphane
- (2008) John D. Clarke et al. CANCER LETTERS
- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
- (2008) X.-J. Wang et al. CARCINOGENESIS
- Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates
- (2008) Roderick H Dashwood et al. NUTRITION REVIEWS
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