Biochemical Evaluation of the Antioxidant Effects of Hydroxytyrosol on Pancreatitis-Associated Gut Injury

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

(2020) Manuela Leri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model

(2020) Siwon Kim et al.   NEUROPHARMACOLOGY

The Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale L. Cashew Nuts in a Mouse Model of Colitis

(2020) Rosalba Siracusa et al.   Nutrients

Protective Effect of Hydroxytyrosol Against Oxidative Stress Induced by the Ochratoxin in Kidney Cells: in vitro and in vivo Study

(2020) Rosalia Crupi et al.   Frontiers in Veterinary Science

Butyrate ameliorates caerulein‐induced acute pancreatitis and associated intestinal injury by tissue specific mechanisms

(2019) Xiaohua Pan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice

(2019) Sudarshan R. Malla et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways

(2018) Tatiana Montoya et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

TH1 and TH2 Cytokine Profiles as Predictors of Severity in Acute Pancreatitis

(2018) Antonio Rodriguez-Nicolas et al.   PANCREAS

Anti-inflammatory effect of ATB-352, a H2S −releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats

(2018) Enrico Gugliandolo et al.   PHARMACOLOGICAL RESEARCH

Adhesion molecules and pancreatitis

(2018) Takeshi Sato et al.   JOURNAL OF GASTROENTEROLOGY

Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis

(2018) Roberta Fusco et al.   Oncotarget

Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling

(2018) Man Zhang et al.   Frontiers in Pharmacology

Anti-oxidant and anti-inflammatory effects of a flavonoid-rich extract from orange juice in experimental colitis

(2017) Roberta Fusco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

(2017) Anna S. Gukovskaya et al.   GASTROENTEROLOGY

Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

(2017) Elisabetta Bigagli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Methane-rich saline alleviates cerulein-induced acute pancreatitis by inhibiting inflammatory response, oxidative stress and pancreatic apoptosis in mice

(2017) Qun Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Capsaicin-Sensitive Sensory Nerves Are Necessary for the Protective Effect of Ghrelin in Cerulein-Induced Acute Pancreatitis in Rats

(2017) Joanna Bonior et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

(2017) Paulina Dumnicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions

(2017) Francisca Echeverría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells

(2017) Dimitra Zagoura et al.   NEUROCHEMISTRY INTERNATIONAL

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury

(2017) Enrico Gugliandolo et al.   PHARMACOLOGICAL RESEARCH

Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia

(2017) Marika Cordaro et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inulin-Type Fructans Modulates Pancreatic–Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner

(2017) Yue He et al.   Frontiers in Immunology

Hyperbaric oxygen preconditioning protects the lung against acute pancreatitis induced injury via attenuating inflammation and oxidative stress in a nitric oxide dependent manner

(2016) Qi-hong Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans

(2016) Raquel Mateos et al.   FOOD CHEMISTRY

Cell-specific Activation of the Nrf2 Antioxidant Pathway Increases Mucosal Inflammation in Acute but Not in Chronic Colitis

(2016) Alexandra Gerstgrasser et al.   Journal of Crohns & Colitis

Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice

(2016) YUAN-YUAN DENG et al.   Molecular Medicine Reports

Severity of pancreatitis-associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin

(2016) Wenhong Deng et al.   Molecular Medicine Reports

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones

(2016) Aya Umeno et al.   MOLECULES

Immunopathogenesis of pancreatitis

(2016) T Watanabe et al.   Mucosal Immunology

Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

(2016) Zhaojun Dong et al.   Oxidative Medicine and Cellular Longevity

Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis

(2016) Ze-Si Lin et al.   PHYTOTHERAPY RESEARCH

Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice

(2016) Guotao Lu et al.   Biomed Research International

Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring

(2015) Adi Zheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

(2015) S. Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Acute pancreatitis

(2015) Paul Georg Lankisch et al.   LANCET

Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury

(2015) Jing-Wen Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

Redox signaling in acute pancreatitis

(2015) Salvador Pérez et al.   Redox Biology

Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer

(2014) Sergio Granados-Principal et al.   BIOCHEMICAL PHARMACOLOGY

Regional Arterial Infusion with Lipoxin A4 Attenuates Experimental Severe Acute Pancreatitis

(2014) Fajing Yang et al.   PLoS One

Vascular effects of the Mediterranean diet—Part II: Role of omega-3 fatty acids and olive oil polyphenols

(2014) Egeria Scoditti et al.   VASCULAR PHARMACOLOGY

Treatment of severe acute pancreatitis and its complications

(2014) Enver Zerem   WORLD JOURNAL OF GASTROENTEROLOGY

Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition

(2013) Egeria Scoditti et al.   ATHEROSCLEROSIS

Phenylpropanoid glycosides from plant cell cultures induce heme oxygenase 1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors

(2012) Anna Sgarbossa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

(2012) Matthias Sendler et al.   GUT

Heme Oxygenase 1–Generated Carbon Monoxide and Biliverdin Attenuate the Course of Experimental Necrotizing Pancreatitis

(2012) Philipp Nuhn et al.   PANCREAS

Experimental and clinical evidence of antioxidant therapy in acute pancreatitis

(2012) Mukaddes Esrefoglu   WORLD JOURNAL OF GASTROENTEROLOGY

Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-β1 in the pathophysiology of acute pancreatitis

(2011) Kyung Don Ju et al.   INFLAMMATION RESEARCH

Hydroxytyrosol Is the Major Anti-Inflammatory Compound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Production in Macrophages

(2011) Nathalie Richard et al.   PLANTA MEDICA

Polyphenol oxidase and its relationship with oleuropein concentration in fruits and leaves of olive (Olea europaea) cv. 'Picual' trees during fruit ripening

(2011) F. Ortega-Garcia et al.   TREE PHYSIOLOGY

Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells

(2010) Monica Deiana et al.   FOOD AND CHEMICAL TOXICOLOGY

Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours

(2010) Sergio Granados-Principal et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Gingival vascular damage in atherosclerotic rabbits: Hydroxytyrosol and squalene benefits

(2009) Pedro Bullon et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification of Throuba Thassos, a Traditional Greek Table Olive Variety, as a Nutritional Rich Source of Oleuropein

(2009) Evagelia Zoidou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol

(2009) Alessandra Incani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with α-linolenic acid on postprandial endothelial function in healthy men

(2008) F. Fuentes et al.   BRITISH JOURNAL OF NUTRITION