Article
Plant Sciences
Sorelle Ines Fotsing, Judith Christiane Ngo Pambe, Kevine Kamga Silihe, Natacha Lena Yembeau, Armand Choupo, Dieudonne Njamen, Constant Anatole Pieme, Stephane Zingue
Summary: In this study, the anti-breast cancer activity of the ethanolic extract of Passiflora edulis leaves was evaluated in vitro and in vivo. The results showed that the extract significantly inhibited the growth and proliferation of breast cancer cells and induced apoptosis. In addition, the extract also reduced tumor incidence and burden, and improved antioxidant and anti-inflammatory capacities in the in vivo experiment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huseyin Fatih Gul, Necip Ilhan, Nevin Ilhan, Ibrahim Hanifi Ozercan, Tuncay Kuloglu
Summary: The study aimed to investigate the protective effects of pomegranate extract and tangeretin alone or in combination in a rat breast cancer model. The results showed that the combined application of pomegranate extract and tangeretin may be more beneficial in preventing breast cancer development, by reducing tumor markers, angiogenesis parameters, and influencing protein expressions to decrease apoptosis and proliferation of cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maite Garcia-Guasch, Eduard Escrich, Raquel Moral, Iola F. Duarte
Summary: The aim of this study was to investigate the effects of two phenolic compounds, hydroxytyrosol (HT) and luteolin (LUT), on the metabolism of breast cancer cells of different molecular subtypes. The researchers used untargeted metabolomics to study the metabolic responses of MDA-MB-231 and MCF-7 cells to treatment with these phenols. The results showed that the effects of the phenolic compounds varied depending on the cell type and included changes in mitochondrial metabolism, glycolysis, lipid metabolism, and cellular redox status.
Article
Medicine, Research & Experimental
Pankti Patel, Jigna Shah
Summary: The study demonstrated that hesperidin alone and in combination with doxorubicin showed protective effects against experimentally induced breast cancer in female rats by reducing tumor occurrence, volume, and improving survival rates. Hesperidin pretreatment also led to significant reduction in malondialdehyde levels, improvement in glutathione levels, and modulation of inflammatory markers in doxorubicin treated animals. Additionally, histopathological analysis revealed better control of tumor growth in hesperidin pretreatment groups compared to DMBA-induced groups.
Article
Oncology
Takahiro Yamazaki, Erik Wennerberg, Michal Hensler, Aitziber Buque, Jeffrey Kraynak, Jitka Fucikova, Xi Kathy Zhou, Baldur Sveinbjornsson, Oystein Rekdal, Sandra Demaria, Lorenzo Galluzzi
Summary: LTX-315 controls breast cancer progression by engaging NK cell-dependent immunity and can be boosted by radiation therapy.
Article
Medicine, Research & Experimental
Seda Beyaz, Abdullah Aslan, Ozlem Gok, Harun Uslu, Can Ali Agca, Ibrahim Hanifi Ozercan
Summary: The study demonstrates the protective and therapeutic effect of fullerene C-60 nanoparticles on DMBA-induced breast cancer in rats. In vitro experiments show that fullerene C-60 inhibits the viability of MCF-7 cells. In vivo experiments reveal changes in apoptotic and inflammatory protein levels in rats treated with fullerene C-60.
Article
Genetics & Heredity
Shan Wang, Pei Shang, Guangyu Yao, Changsheng Ye, Lujia Chen, Xiaolei Hu
Summary: This study delved into the molecular mechanisms of breast cancer at the genomic and transcriptomic levels in different subtypes, aiming to provide a theoretical basis for personalized treatments and precision medicine. It was found that carcinogenesis and development of triple-negative breast cancer were the most important and complex processes, and the luminal A subtype exhibited a different pathogenesis compared to the other subtypes. Additionally, 16 hub genes related to good prognosis in triple-negative breast cancer were identified, and new transcription factors and microRNAs were introduced, offering novel perspectives for breast cancer research and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Lanyang Gao, Lei Zhu, Chen Shen, Xiaoming Hou, Youyou Chen, Linglin Zou, Huiyan Qiang, Alexander T. Teichmann, Wenguang Fu, Yao Luo
Summary: 4-OHA cream can effectively inhibit the growth of breast cancer, with similar anti-tumor effects as its injection formulation. It can also enhance immune cell infiltration in mammary tumor tissues, suggesting its potential value in neoadjuvant treatment of ER+ breast cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Marina K. Ibragimova, Matvey M. Tsyganov, Nikolai V. Litviakov
Summary: Breast cancer is a genetically heterogeneous disease with different molecular biological and clinical characteristics, impacting drug treatment and prognosis. Understanding the genetic phenotype of breast cancer allows for personalized treatment and prognostic prediction.
Article
Pharmacology & Pharmacy
Girish Meravanige Basavarajappa, Abdur Rehman, Predeepkumar Narayanappa Shiroorkar, Nagaraja Sreeharsha, Md. Khalid Anwer, Bandar Aloufi
Summary: Breast cancer is a silent killer disorder among women and a serious economic burden. Despite advances in research and treatment, rates of breast cancer continue to rise. This study combines data mining, network pharmacology, and docking analysis to explore the potential of Crataegus monogyna in treating breast cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Rassanee Bissanum, Sitthichok Chaichulee, Rawikant Kamolphiwong, Raphatphorn Navakanitworakul, Kanyanatt Kanokwiroon
Summary: TNBC lacks well-defined molecular targets and is highly heterogeneous, making treatment challenging. This study attempted to define gene signatures for each TNBC subtype and develop a classification method using machine learning. SVM algorithm achieved the highest accuracy in classifying TNBC into four subtypes, but some samples could not be classified.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Multidisciplinary Sciences
Nursabillilah Mohd Ali, Rosli Besar, Nor Azlina Ab Aziz
Summary: Breast cancer is the most dominant cancer among women worldwide. Gene expression microarray is employed for accurate classification and prognosis, but suffers from limitations such as large number of features, limited sample size, and irrelevant features, making it difficult to determine the actual features contributing to cancer classification. Therefore, feature selection methods are needed to identify relevant and discriminant feature subsets.
Article
Biochemistry & Molecular Biology
Wataru Sato, Kazuhiro Ikeda, Noriko Gotoh, Satoshi Inoue, Kuniko Horie
Summary: Efp plays a tumor-promotive role in TNBC and may serve as a potential therapeutic target for this aggressive disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Anallely Lopez-Yerena, Anna Vallverdu-Queralt, Rosa M. Lamuela-Raventos, Elvira Escribano-Ferrer
Summary: Using LC-ESI-LTQ-Orbitrap-MS analysis, this study found that oleacein (OLEA) and its metabolites were distributed in various tissues, with unmetabolized OLEA notably present in the heart, suggesting potential implications for cardiovascular disease prevention. The detection of high levels of hydroxytyrosol (OH-TY) and OLEA + CH3 in the small intestine, liver, and plasma, as well as the identification of nine OLEA metabolites, provides deeper insights into the metabolism and tissue distribution of OLEA, contributing to the understanding of its health effects.
Article
Biochemistry & Molecular Biology
Elif Gulbahce-Mutlu, Saltuk Bugra Baltaci, Esma Menevse, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Summary: This study found that combined therapy of zinc and melatonin in female rats with DMBA-induced breast cancer can contribute to preventing tumor growth by improving disruption in element metabolism, suppressing IL-6 levels, and reducing tissue damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Amalia Garcia-Garcia, Sara Rojas, Lorenzo Rivas-Garcia, Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Jose G. Fernandez-Bolanos, Duane Choquesillo-Lazarte, Alfonso Salinas-Castillo, Oscar Lopez, Jose L. Quiles, Antonio Rodriguez-Dieguez
Summary: A new palladium coordination compound based on gliclazide has been synthesized and characterized, showing promising inhibitory activity against an enzyme related to Alzheimer's disease and protective activity in a Caenorhabditis elegans model.
CHEMICAL COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Giuseppe Grosso, Justyna Godos, Walter Currenti, Agnieszka Micek, Luca Falzone, Massimo Libra, Francesca Giampieri, Tamara Y. Forbes-Hernandez, Jose L. Quiles, Maurizio Battino, Sandro La Vignera, Fabio Galvano
Summary: This review examines the effects of dietary polyphenols on vascular health, blood pressure, and hypertension. Evidence suggests that certain polyphenol-rich foods, such as berries, cocoa, green tea, almonds, pistachios, and soy products, can improve blood pressure levels. However, there are limitations to consider, such as the variability of polyphenol content and absorption in plant-derived foods, as well as differences in dosages between animal and human studies.
Article
Environmental Sciences
Justyna Godos, Francesca Giampieri, Emanuele Chisari, Agnieszka Micek, Nadia Paladino, Tamara Y. Forbes-Hernandez, Jose L. Quiles, Maurizio Battino, Sandro La Vignera, Giuseppe Musumeci, Giuseppe Grosso
Summary: Excess alcohol consumption is detrimental to health, while light-to-moderate alcohol intake may have certain cardiovascular benefits. The role of alcohol consumption in bone mineral density and the risk of osteoporotic fractures is still unclear. This study aimed to assess the relationship between alcohol intake and bone mineral density as well as the risk of osteoporotic fractures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Victoria Jimenez-Trigo, Laura Vera-Ramirez, Tamara J. Forbes-Hernandez, Adelaida Esteban-Munoz, Francesca Giampieri, Pedro Bullon, Maurizio Battino, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: This study characterized an olive leaf extract enriched in oleuropein and found that it exhibited no toxicity and improved oxidative stress and proteotoxicity. The study also identified potential molecular mechanisms involving multiple signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Victoria Jimenez-Trigo, Pedro Munoz-Ollero, Tamara Y. Forbes-Hernandez, Adelaida Esteban-Munoz, Francesca Giampieri, Irene Delgado Noya, Pedro Bullon, Laura Vera-Ramirez, Maurizio Battino, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: This study investigated the effects of an olive fruit extract rich in hydroxytyrosol on Alzheimer disease features using Caenorhabditis elegans model. The extract showed antioxidant properties and delayed Aβ-induced paralysis, and the observed effects were mechanistically associated with the regulation of SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2.
Review
Oncology
Beatriz Puente-Cobacho, Alfonso Varela-Lopez, Jose L. Quiles, Laura Vera-Ramirez
Summary: Decades of research have revealed the complexity of tumour cellular and molecular biology, with some progress made in treating primary tumours. However, less progress has been made in developing therapies against metastasis, which is the main cause of cancer-related deaths. Recent studies have shown that epigenetic and microenvironmental factors play a key role in tumour progression. Free radicals act as second messengers and modulate tumour cell signalling, leading to either cell survival or cell death depending on the context. Redox signalling is involved in controlling disseminated tumour cell fate and metastasis.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Araceli Lopez-Tejada, Carmen Grinan-Lison, Adrian Gonzalez-Gonzalez, Francisca E. Cara, Rafael J. Luque, Carmen Rosa-Garrido, Jose L. Blaya-Canovas, Alba Navarro-Ocon, Maria Valenzuela-Torres, Marisa Parra-Lopez, Jesus Calahorra, Isabel Blancas, Juan A. Marchal, Sergio Granados-Principal
Summary: In triple-negative breast cancer (TNBC), the phosphorylation and localization of NDRG1 play an important role in its pleiotropic effects. TGFβ1 has been found to regulate different aspects of TNBC progression, including migration, invasion, epithelial-mesenchymal transition, and cancer stem cell maintenance, through the downstream activation of NDRG1 and NF-κB. The combination of TGFβ and GSK3β inhibitors can impair cancer stem cells in TNBC. The assessment of both total NDRG1 and p-NDRG1 (Thr346) positivity and subcellular localization is crucial for evaluating patient prognosis and stratification.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ana Belen Diaz-Ruano, Nuria Martinez-Alarcon, Macarena Peran, Karim Benabdellah, Maria de los angeles Garcia-Martinez, Ovidiu Preda, Cesar Ramirez-Tortosa, Andrea Gonzalez-Hernandez, Juan Antonio Marchal, Manuel Picon-Ruiz
Summary: The risk of cancer increases with age, but the development of estrogen-receptor-positive (ER+) cancer types in women is more related to menopausal status than age. Obesity-induced inflammation, a general risk factor for cancer, shows differences in its association with ER+ cancer risk in pre- and postmenopausal women. This study demonstrates the different biological functions of estradiol (E2) and estrone (E1) in ER+ gynecologic cancers, highlighting the potential role of E1 and HSD17B E1-synthesizing enzymes in the development and progression of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Navdeep Malik, Young -Im Kim, Hualong Yan, Yu-Chou Tseng, Wendy du Bois, Gamze Ayaz, Andy D. Tran, Laura Vera-Ramirez, Howard Yang, Aleksandra M. Michalowski, Michael Kruhlak, Maxwell Lee, Kent W. Hunter, Jing Huang
Summary: Understanding functional interactions between cancer mutations is crucial for discovering new cancer pathways and developing personalized treatment. In this study, the authors identified driver gene pairs in breast cancer by combining genetic interaction and proteomics data. They found that the PIK3CA mutation and CBFB mutation cooperate to promote breast tumor progression by causing mitochondrial translation dysregulation. Additionally, they demonstrated that combining autophagy and PI3K inhibitors can effectively kill breast cancer cells and inhibit tumor growth. This study provides mechanistic insights and a preclinical rationale for precision medicine in breast cancer.
Review
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Tamara Y. Forbes-Hernandez, Maria D. Navarro-Hortal, Rosa Quirantes-Pine, Giuseppe Grosso, Francesca Giampieri, Vivian Lipari, Cristina Sanchez-Gonzalez, Maurizio Battino, Jose L. Quiles
Summary: Alzheimer's Disease (AD) is a major cause of global dementia cases, affecting around 50 million people worldwide. The leaves of olive trees contain bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT), which have shown medicinal properties in fighting AD. Olive leaf (OL), OLE, and HT can reduce amyloid-beta and neurofibrillary tangles formation, and OL has exhibited high cholinergic inhibitory activity. These compounds may also decrease neuroinflammation and oxidative stress, potentially promoting autophagy and restoring loss of proteostasis in AD models. Therefore, olive phytochemicals hold promise as an adjuvant in AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lorenzo Rivas-Garcia, Alfonso Lopez-Varela, Jose L. Quiles, Maria Montes-Bayon, Pilar Aranda, Juan Llopis, Cristina Sanchez-Gonzalez
Summary: The present study aimed to evaluate the effect of co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV) (BMOV) on reducing the toxicity of BMOV. The results showed that co-incubation with both metals effectively reduced the toxicity of BMOV and enhanced its potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Francisco J. Orantes, Adelaida Esteban-Munoz, Cristina M. Perez-Oleaga, Maurizio Battino, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Francesca Giampieri, Jose L. Quiles, Tamara Y. Forbes-Hernandez
Summary: This study aims to characterize monofloral avocado honey (AH) and evaluate its phenolic profile and antioxidant capacity. The results show that AH exhibits high antioxidant capacity in vitro and in vivo, which is relevant for the prevention of Alzheimer's disease.
Article
Chemistry, Applied
Danila Cianciosi, Yasmany Armas Diaz, Jose M. Alvarez-Suarez, Xiumin Chen, Di Zhang, Nohora Milena Martinez L. Lopez, Mercedes Briones Urbano, Jose L. Quiles, Adolfo Amici, Maurizio Battino, Francesca Giampieri
Summary: This study investigated the chemosensitizing effects of Manuka honey against 5-Fluorouracil in colonspheres enriched with cancer stem cells (CSCs). The results showed that combining Manuka honey with 5-Fluorouracil decreased the gene expression of ABC sub-family G member 2 and thymidylate synthase, which are associated with drug resistance and DNA synthesis respectively. Manuka honey also regulated the Wnt/β-catenin, Hedgehog and Notch pathways, reducing the self-renewal ability of CSCs. This preliminary study opens new possibilities for the combination of natural compounds and pharmaceuticals to enhance efficacy or reduce adverse effects.
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Tamara Y. Forbes-Hernandez, Alfonso Varela-Lopez, Juan G. Puentes, Raquel Del Pino-Garcia, Cristina Sanchez-Gonzalez, Inaki Elio, Maurizio Battino, Roberto Garcia, Sebastian Sanchez, Jose L. Quiles
Summary: In this study, olive leaves from different geographical origins were analyzed for their phytochemical profile, antioxidant capacity, neuroprotective activity, and anti-inflammatory effects. The results showed that olive leaves from Spain and Italy had the highest antioxidant and neuroprotective activities, while those from Greece had the lowest. The content of oleoside methyl ester and p-hydroxybenzoic acid in the Spanish and Italian samples, respectively, were strongly associated with these biological activities.
