Article
Biochemistry & Molecular Biology
Richard E. Frye, Janet Cakir, Shannon Rose, Leanna Delhey, Sirish C. Bennuri, Marie Tippett, Stepan Melnyk, S. Jill James, Raymond F. Palmer, Christine Austin, Paul Curtin, Manish Arora
Summary: By investigating the role of mitochondria in the influence of prenatal air pollution exposure on neurodevelopment and behavior in children with ASD, it was found that mitochondrial respiration is influenced by PM2.5 exposure during childhood, with varying effects on children with and without NDR. Mitochondrial respiration linked to energy production accounted for a portion of the effect of average prenatal PM2.5 exposure on neurodevelopment and behavioral symptoms. Structural equation models estimated that PM2.5 and mitochondrial respiration contribute to the effect on neurodevelopment, while behavior is directly influenced by prenatal PM2.5 exposure.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Xiaorong Zhang, Yun Jiang, Jiajie Mao, Xuekun Ren, Yinghui Ji, Yixin Mao, Yang Chen, Xiaoyu Sun, Yihuai Pan, Jianfeng Ma, Shengbin Huang
Summary: Researches have shown that hydroxytyrosol (HT) can inhibit osteoclast differentiation and prevent alveolar bone loss in periodontitis by regulating mitochondrial function and signaling pathways, increasing bone forming activity, and has therapeutic potential in preventing and treating periodontitis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
David C. Geary
Summary: Cognitive abilities, brain networks, and mitochondrial energy production are interconnected, playing important roles in health and aging. Integrating cognitive science and cell biology research can lead to more sensitive measures of age- and disease-related declines in cognition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yan Hu, Yile Zhou, Yajie Yang, Haihong Tang, Yuan Si, Zhouyi Chen, Yi Shi, Hao Fang
Summary: Diabetes is a risk factor for dementia, and this study explored the role of mitochondrial dynamic changes in diabetes-associated cognitive impairment. Diabetic mice showed memory loss and spatial disorientation, along with changes in mitochondria morphology and increased oxidative stress in hippocampal neurons. Inhibition of mitochondrial fission and treatment with metformin reduced oxidative stress and prevented cell apoptosis in cultured neurons. Moreover, metformin restored cognitive function in diabetic mice by inhibiting mitochondrial fission and reducing oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenfei Yu, Zhuxun Li, Wenjing Wu, Dandan Zhao, Chuanzhu Yan, Pengfei Lin
Summary: This study investigated the mechanisms underlying telbivudine-induced myopathy and found that it is associated with mitochondrial toxicity and impaired energy metabolism. This provides evidence supporting the common mechanism of NAs causing neuromyopathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Fisheries
Huifan Liu, Yuke Fang, Cuiyun Zou
Summary: This study found that crude polysaccharide YZW-A extracted from pomelo fruitlets has protective effects on oxidative stress, inflammation, and mitochondrial dysfunction-mediated apoptosis. YZW-A increased activities of mitochondrial respiratory complexes and antioxidative enzymes, decreased expression of proinflammatory cytokines, and alleviated cell apoptosis through mitigating oxidative stress. These results suggest the therapeutic potential of YZW-A on aquatic animals.
Article
Biotechnology & Applied Microbiology
Youyu Wang, Bo Jiang, Wang Luo
Summary: Memantine can alleviate oxidative stress and mitochondrial damage caused by oxaliplatin in neuronal cells, thus protecting neurons from cytotoxic effects.
Article
Immunology
Qian Wang, Zhenzhen Sun, Shihan Cao, Xiuli Lin, Mengying Wu, Yuanyuan Li, Jie Yin, Wei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Weiwei Xia, Zhanjun Jia
Summary: The study reveals the involvement of MAVS in cardiac dysfunction, showing reduced MAVS expression in non-hypertrophic cardiac dysfunction and enhanced MAVS expression in hypertrophic heart. MAVS deficiency leads to cardiac dysfunction, mitochondrial impairment, and disturbed energy metabolism. These findings suggest a crucial role of MAVS in the pathogenesis of non-hypertrophic cardiac dysfunction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jay Kumar, Ghulam Mohammad, Kumari Alka, Renu A. Kowluru
Summary: Mitochondrial dysfunction plays a critical role in the development of diabetic retinopathy. Hyperglycemia downregulates the mtDNA-encoded LncRNA cytochrome B (LncCytB) in retinal endothelial cells, leading to impaired mtDNA packaging and increased vulnerability to damage.
Article
Biology
Antoine Stier, Pat Monaghan, Neil B. Metcalfe
Summary: Variation in mitochondrial function among individuals may contribute to differences in individual performance and health state. It has been hypothesized that prenatal conditions could program postnatal mitochondrial function, with potential lasting effects. This study tested this hypothesis in birds by manipulating incubation temperature and stability, and found that high incubation temperature led to a consistent and long-lasting increase in mitochondrial aerobic metabolism. However, prenatal temperature conditions only explained a small proportion of the observed among-individual differences.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thomas B. Shea
Summary: This study reviews the various mechanisms of cognitive decline, neuronal function decrease, and neuronal loss, attributing these to oxidative stress. It suggests that a combination of compounds, rather than individual ones, is optimal for neuronal protection. Compounds providing antioxidant protection are particularly effective in delaying cognitive impairment in the early stages of Mild Cognitive Impairment and Alzheimer's disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Fisheries
Yanzou Dong, Tian Xia, Manhan Yu, Ling Wang, Kai Song, Chunxiao Zhang, Kangle Lu
Summary: This study found that adding hydroxytyrosol to a high-fat diet can attenuate oxidative stress, inflammation, and cell apoptosis in blunt snout bream. Hydroxytyrosol reduces the production of reactive oxygen species, increases the activity of mitochondrial complexes, and promotes mitochondrial autophagy and biogenesis.
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Summary: Reactive oxygen species (ROS) are highly reactive molecules generated as a by-product of aerobic life, which can lead to oxidative stress and the formation of bioactive compounds like 4-hydroxynonenal (4-HNE). 4-HNE forms covalent adducts with proteins, nucleic acids, and lipids, affecting mitochondrial functions and promoting apoptosis.
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Xueqiang Wang, Weiqiang Lv, Jie Xu, Adi Zheng, Mengqi Zeng, Ke Cao, Xun Wang, Yuting Cui, Hao Li, Meng Yang, Yongping Shao, Fang Zhang, Xuan Zou, Jiangang Long, Zhihui Feng, Jiankang Liu
Summary: Alternate day fasting (ADF) leads to metabolic reprogramming in the liver and dysfunction of complex II. Knockout of the Sdhaf4 gene in the liver improves glucose tolerance and systemic insulin sensitivity, similar to the effects of ADF intervention. Hepatocytes activate the arginine-nitric oxide (NO) biosynthesis axis in response to complex II and citric acid cycle dysfunction, and the released NO enhances insulin sensitivity in muscle and adipocytes.
Review
Biochemistry & Molecular Biology
Jie Xu, Ke Cao, Xuyun Liu, Lin Zhao, Zhihui Feng, Jiankang Liu
Summary: Punicalagin, the major active component of pomegranate extracts, has potential therapeutic effects on inflammation-associated chronic diseases and regulates multiple signaling pathways.
Article
Environmental Sciences
Yingying Fan, Jian Wang, Zhihui Feng, Ke Cao, Jiankang Liu, Hao Xu
Summary: The combination therapy of hydrogen and oxygen shows a superior protective effect on acute lung injury, with hydrogen playing a more important role in inflammatory and anti-apoptosis mechanisms, while oxygen improving hypoxia in the body.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Gastroenterology & Hepatology
Nadia Bresciani, Hadrien Demagny, Vera Lemos, Francesca Pontanari, Xiaoxu Li, Yu Sun, Hao Li, Alessia Perino, Johan Auwerx, Kristina Schoonjans
Summary: Here, we highlight the significance of a locus containing a liver-specific gene encoding a mitochondrial transport protein called SLC25A47. We demonstrate that mice with genetic disruption of the Slc25a47 locus fail to maintain mitochondrial homeostasis, leading to diverse liver abnormalities and profound physiological consequences.
JOURNAL OF HEPATOLOGY
(2022)
Correction
Multidisciplinary Sciences
Xueqiang Wang, Xing Zhang, Ke Cao, Mengqi Zeng, Xuyang Fu, Adi Zheng, Feng Zhang, Feng Gao, Xuan Zou, Hao Li, Min Li, Weiqiang Lv, Jie Xu, Jiangang Long, Weijin Zang, Jinghai Chen, Feng Gao, Jian Ding, Jiankang Liu, Zhihui Feng
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xueqiang Wang, Xing Zhang, Ke Cao, Mengqi Zeng, Xuyang Fu, Adi Zheng, Feng Zhang, Feng Gao, Xuan Zou, Hao Li, Min Li, Weiqiang Lv, Jie Xu, Jiangang Long, Weijin Zang, Jinghai Chen, Jian Ding, Jiankang Liu, Zhihui Feng
Summary: This study reveals the importance of succinate dehydrogenase complex II assembly in the development of dilated cardiomyopathy and provides insights into potential therapeutic interventions for heart diseases.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Hao Li, Alessia Perino, Qingyao Huang, Giacomo V. G. Von Alvensleben, Amir Banaei-Esfahani, Laura A. Velazquez-Villegas, Karim Gariani, Melanie Korbelius, Maroun Bou Sleiman, Jeromine Imbach, Yu Sun, Xiaoxu Li, Alexis Bachmann, Ludger J. E. Goeminne, Hector Gallart-Ayala, Evan G. Williams, Julijana Ivanisevic, Johan Auwerx, Kristina Schoonjans
Summary: This study comprehensively investigates the role of bile acids in metabolic traits using a mouse model, revealing regulators of bile acid homeostasis and the association between CES1C and plasma TUDCA, a bile acid species with disease-preventing actions.
Article
Cell Biology
Terytty Yang Li, Arwen W. Gao, Xiaoxu Li, Hao Li, Yasmine J. Liu, Amelia Lalou, Nagammal Neelagandan, Felix Naef, Kristina Schoonjans, Johan Auwerx
Summary: Stressed mitochondria activate the mitochondrial unfolded protein response (UPRmt) to improve organismal health. A study found that increased ATFS-1 translation, mediated by v-ATPase/TORC1, plays an essential role in UPRmt activation and mild mitochondrial stress-induced longevity.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Maroun Bou Sleiman, Suheeta Roy, Arwen W. Gao, Marie C. Sadler, Giacomo V. G. von Alvensleben, Hao Li, Saunak Sen, David E. Harrison, James F. Nelson, Randy Strong, Richard A. Miller, Zoltan Kutalik, Robert W. Williams, Johan Auwerx
Summary: This study provides insights into the determinants of health, disease, and aging by examining DNA variants that affect life span. The researchers identified sex-specific genetic effects on life span and gene expression, and validated several genes as conserved longevity genes. The findings underscore the importance of early access to nutrients and early growth for longevity.
Article
Cell Biology
Tanes I. Lima, Pirkka-Pekka Laurila, Martin Wohlwend, Jean David Morel, Ludger J. E. Goeminne, Hao Li, Mario Romani, Xiaoxu Li, Chang-Myung Oh, Dohyun Park, Sandra Rodriguez-Lopez, Julijana Ivanisevic, Hector Gallart-Ayala, Barbara Crisol, Florence Delort, Sabrina Batonnet-Pichon, Leonardo R. Silveira, Lakshmi Sankabattula Pavani Veera Venkata, Anil K. Padala, Suresh Jain, Johan Auwerx
Summary: Disruption of ceramide biosynthesis leads to the decline in mitochondrial and protein homeostasis during muscle aging. Through transcriptome analysis of muscle biopsies, it was found that disturbance in ceramide biosynthesis, mitochondrial function, and protein homeostasis are prevalent features in aged individuals and patients with muscle disorders. Inhibition of ceramide biosynthesis restores proteostasis and mitochondrial function, improving muscle health and lifespan in both nematodes and mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Manqiang Lin, Kimberly Hartl, Julian Heuberger, Giulia Beccaceci, Hilmar Berger, Hao Li, Lichao Liu, Stefanie Muellerke, Thomas Conrad, Felix Heymann, Andrew Woehler, Frank Tacke, Nikolaus Rajewsky, Michael Sigal
Summary: Most intestinal organoid models do not accurately model the interactions between epithelial and stromal cells. Here they establish a colon assembloid system with epithelial and stromal cells and demonstrate that BMP signals from differentiating epithelial cells promote mesenchymal niche organization.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Ke Cao, Jie Xu, Wenli Cao, Xueqiang Wang, Weiqiang Lv, Mengqi Zeng, Xuan Zou, Jiankang Liu, Zhihui Feng
Summary: Mitochondrial succinate dehydrogenase (SDH) is an enzyme complex that plays a crucial role in regulating mitochondrial metabolism and human health. Recent studies have revealed the dynamic involvement of SDH assembly process in various diseases. Perturbation of SDH assembly in different tissues can lead to distinct pathophysiological changes, highlighting the importance of understanding the intricate SDH assembly process in human health and diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Jie Xu, Zhihui Feng
Article
Biochemistry & Molecular Biology
Yue Xiong, Jie Xu, Wenli Cao, Jiawei Zhang, Zhihui Feng, Ke Cao, Jiankang Liu
Summary: This study explored the beneficial effects of hydroxytyrosol (HT) on strenuous exercise-induced pathological changes in the heart. HT improved heart weight and morphology, decreased cardiac hypertrophy markers and oxidative stress. It also improved mitochondrial biogenesis, mitochondrial complex activity, expression of mitochondrial dynamics-related proteins, and activated apoptotic pathway. In an in vitro model, HT reduced reactive oxygen species level, promoted mitochondrial biogenesis, and inhibited apoptosis and cardiomyocyte hypertrophy. Knockdown of key regulator PPARGC1A partially abolished the benefits of HT, indicating its involvement in mitochondrial homeostasis.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)