Immunopathogenesis of pancreatitis

The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis

(2016) Rui Kang et al.   JOURNAL OF IMMUNOLOGY

Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis

(2016) T Watanabe et al.   Mucosal Immunology

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammasomes in pancreatic physiology and disease

(2015) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis

(2015) Mohammed Merza et al.   GASTROENTEROLOGY

Impaired Autophagy Induces Chronic Atrophic Pancreatitis in Mice via Sex- and Nutrition-Dependent Processes

(2015) Kalliope N. Diakopoulos et al.   GASTROENTEROLOGY

Serum Interleukin 17 as An Early Prognostic Biomarker of Severe Acute Pancreatitis Receiving Continuous Blood Purification

(2015) Shu R. Dai et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

The role of Card9 overexpression in peripheral blood mononuclear cells from patients with aseptic acute pancreatitis

(2015) Zhi-wen Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acute pancreatitis

(2015) Paul Georg Lankisch et al.   LANCET

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

(2015) Laura Antonucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

(2015) Jing Xue et al.   Nature Communications

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

Bacteremia in Patients With Acute Pancreatitis as Revealed by 16S Ribosomal RNA Gene-Based Techniques*

(2013) Qiurong Li et al.   CRITICAL CARE MEDICINE

Cerulein-Induced Chronic Pancreatitis Does Not Require Intra-Acinar Activation of Trypsinogen in Mice

(2013) Raghuwansh P. Sah et al.   GASTROENTEROLOGY

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

(2013) Ilya Gukovsky et al.   GASTROENTEROLOGY

Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice

(2013) Rui Kang et al.   GASTROENTEROLOGY

Autoactivation of Mouse Trypsinogens Is Regulated by Chymotrypsin C via Cleavage of the Autolysis Loop

(2013) Balázs Csaba Németh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

(2013) Ning Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The IL-33/ST2 Pathway Controls Coxsackievirus B5-Induced Experimental Pancreatitis

(2013) R. Sesti-Costa et al.   JOURNAL OF IMMUNOLOGY

The role of protein synthesis and digestive enzymes in acinar cell injury

(2013) Craig D. Logsdon et al.   Nature Reviews Gastroenterology & Hepatology

Pancreatic stellate cells – Multi-functional cells in the pancreas

(2013) Atsushi Masamune et al.   PANCREATOLOGY

The Novel Cytokine Interleukin-33 Activates Acinar Cell Proinflammatory Pathways and Induces Acute Pancreatic Inflammation in Mice

(2013) Duraisamy Kempuraj et al.   PLoS One

The ST2 Pathway Is Involved in Acute Pancreatitis

(2012) Romy Ouziel et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy and pancreatitis

(2012) Anna S. Gukovskaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice

(2012) Keita Saeki et al.   GASTROENTEROLOGY

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

(2012) Matthias Sendler et al.   GUT

Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis

(2012) Yoshihisa Tsuji et al.   IMMUNITY

MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells

(2012) Atsuo Ochi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sterile Inflammatory Response in Acute Pancreatitis

(2012) Rafaz Hoque et al.   PANCREAS

Molecular mechanisms of pancreatic injury

(2011) Raghuwansh P. Sah et al.   CURRENT OPINION IN GASTROENTEROLOGY

Dendritic Cells Promote Pancreatic Viability in Mice With Acute Pancreatitis

(2011) Andrea S. Bedrosian et al.   GASTROENTEROLOGY

Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis

(2011) Rajinder Dawra et al.   GASTROENTEROLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Digesting New Information About the Role of Trypsin in Pancreatitis

(2011) Baoan Ji et al.   GASTROENTEROLOGY

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

(2011) Rafaz Hoque et al.   GASTROENTEROLOGY

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis

(2011) S. Gaiser et al.   GUT

Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis

(2011) Aree Abdulla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic pancreatitis

(2011) Joan M Braganza et al.   LANCET

Cytokines and Organ Failure in Acute Pancreatitis

(2011) Marie Louise Malmstrøm et al.   PANCREAS

The Emerging Role of Smoking in the Development of Pancreatitis

(2011) Martine Alexandre et al.   PANCREATOLOGY

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Genetic Aspects of Pancreatitis

(2010) David C. Whitcomb   Annual Review of Medicine

Patients with acute pancreatitis complicated by organ failure show highly aberrant monocyte signaling profiles assessed by phospho-specific flow cytometry*

(2010) Jani Oiva et al.   CRITICAL CARE MEDICINE

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation

(2009) Pui Y. Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

(2009) Franco Fortunato et al.   GASTROENTEROLOGY

Chronic Pancreatitis Is Associated With Disease-Specific Regulatory T-Cell Responses

(2009) Hubertus Schmitz–Winnenthal et al.   GASTROENTEROLOGY

Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice

(2009) R Sharif et al.   GUT

Intracellular Trypsin Induces Pancreatic Acinar Cell Death but Not NF-κB Activation

(2009) Baoan Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis

(2009) Jakub W. Rychter et al.   SURGERY

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Acute pancreatitis

(2008) Jean-Louis Frossard et al.   LANCET

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Monocyte Chemoattractant Protein 1, Active Carboxypeptidase B and CAPAP at Hospital Admission Are Predictive Markers for Severe Acute Pancreatitis

(2008) S. Régner et al.   PANCREATOLOGY

SOCS 3 and PPAR-γ ligands inhibit the expression of IL-6 and TGF-β1 by regulating JAK2/STAT3 signaling in pancreas

(2007) Ji Hoon Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY