Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

Receptor‐Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells

(2020) Kana Otsubo et al.   FEBS LETTERS

Pathway paradigms revealed from the genetics of inflammatory bowel disease

(2020) Daniel B. Graham et al.   NATURE

Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling

(2020) Jixiang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer

(2020) Yadong Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

MiR-141-3p ameliorates RIPK1-mediated necroptosis of intestinal epithelial cells in necrotizing enterocolitis

(2020) Xiang Li et al.   Aging-US

Cross talk between intracellular pathogens and cell death

(2020) Benjamin Demarco et al.   IMMUNOLOGICAL REVIEWS

ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through Recruiting A20 and Restricting the Ubiquitination of RIPK3 in Inflammatory Bowel Disease

(2020) Mingxia Zhou et al.   Journal of Crohns & Colitis

Cell death in the gut epithelium and implications for chronic inflammation

(2020) Jay V. Patankar et al.   Nature Reviews Gastroenterology & Hepatology

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models

(2019) Ting Zhou et al.   Cell Death & Disease

MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota

(2019) Jie Zhang et al.   MOLECULAR IMMUNOLOGY

Activated MLKL attenuates autophagy following its translocation to intracellular membranes

(2019) Daniel Frank et al.   JOURNAL OF CELL SCIENCE

Cell Death and Liver Disease

(2019) Satoka Aizawa et al.   Gut and Liver

The role of necroptosis in cancer: A double-edged sword?

(2019) Xia Qin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing phosphorylation of RIPK1 and alleviates dextran sulfate sodium-induced colitis

(2019) Chong Zhang et al.   CLINICAL SCIENCE

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

(2019) Kazuhito Sai et al.   JOURNAL OF CELL BIOLOGY

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

(2019) Apostolos Polykratis et al.   NATURE CELL BIOLOGY

Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis

(2019) Kewei Wang et al.   Gastroenterology Research and Practice

Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells

(2019) Chong Zhang et al.   Cell Death & Disease

Salmonella Outer Protein B Suppresses Colitis Development via Protecting Cell From Necroptosis

(2019) Gui-Qiu Hu et al.   Frontiers in Cellular and Infection Microbiology

Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease

(2019) Claudia Günther et al.   GASTROENTEROLOGY

Survival and death of intestinal cells infected by Chlamydia trachomatis

(2019) Claudio Foschi et al.   PLoS One

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

(2019) Annelise G. Snyder et al.   Science Immunology

MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses

(2019) Qun Zhao et al.   CANCER LETTERS

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

(2019) Susana L. Orozco et al.   Cell Reports

The Molecular Links between Cell Death and Inflammasome

(2019) Kwang-Ho Lee et al.   Cells

Necroptosis in the Pathophysiology of Disease

(2019) Mitri K. Khoury et al.   AMERICAN JOURNAL OF PATHOLOGY

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

(2019) Yiwei Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Current translational potential and underlying molecular mechanisms of necroptosis

(2019) Tamás Molnár et al.   Cell Death & Disease

Molecular Insights into the Mechanism of Necroptosis: The Necrosome as a Potential Therapeutic Target

(2019) Jing Chen et al.   Cells

Prognostic and clinicopathological significance of MLKL expression in cancer patients: a meta-analysis

(2018) Binwu Hu et al.   BMC CANCER

A RIPK3-PGE2 circuit mediates myeloid-derived suppressor cell-potentiated colorectal carcinogenesis

(2018) Guifang Yan et al.   CANCER RESEARCH

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation

(2018) Swati Roy et al.   GASTROENTEROLOGY

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival

(2018) Michael G. Kattah et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Necroptosis in cardiovascular disease - a new therapeutic target

(2018) Kartik Gupta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis

(2018) Qinrui Han et al.   Journal of Translational Medicine

Flaxseed Oil Attenuates Intestinal Damage and Inflammation by Regulating Necroptosis and TLR4/NOD Signaling Pathways Following Lipopolysaccharide Challenge in a Piglet Model

(2018) Huiling Zhu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

BiallelicRIPK1mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

(2018) Delphine Cuchet-Lourenço et al.   SCIENCE

The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis

(2018) Johaiber Fuchslocher Chico et al.   Oncotarget

Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins

(2018) Mauricio Navarro et al.   Toxins

Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

(2018) Shui-Xing Yu et al.   Frontiers in Immunology

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

(2018) Konrad Aden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

(2018) Lien Van Hoecke et al.   Nature Communications

Comparing the effects of different cell death programs in tumor progression and immunotherapy

(2018) Michelle N. Messmer et al.   CELL DEATH AND DIFFERENTIATION

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine

(2017) René Pagel et al.   FASEB JOURNAL

RIPK3 in cell death and inflammation: the good, the bad, and the ugly

(2017) Susana Orozco et al.   IMMUNOLOGICAL REVIEWS

Exogenous hydrogen sulfide protects human umbilical vein endothelial cells against high glucose‑induced injury by inhibiting the necroptosis pathway

(2017) Jiaqiong Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Necroptosis: A novel manner of cell death, associated with stroke (Review)

(2017) Chenglin Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A novel damage mechanism: Contribution of the interaction between necroptosis and ROS to high glucose-induced injury and inflammation in H9c2 cardiac cells

(2017) Weijie Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

(2017) Gui-Wei He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

(2017) Yan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

TNF Signaling through RIP1 Kinase Enhances SN38-Induced Death in Colon Adenocarcinoma

(2017) Lucia Cabal-Hierro et al.   MOLECULAR CANCER RESEARCH

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

(2017) Slawomir A. Dziedzic et al.   NATURE CELL BIOLOGY

Necroptosis Is Involved in CD4+ T Cell-Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection

(2017) Cecilia Kwok et al.   TRANSPLANTATION

Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis

(2017) et al.   Viruses-Basel

Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis

(2017) Chengkui Yang et al.   Cell Death & Disease

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Protective effect of NSA on intestinal epithelial cells in a necroptosis model

(2017) Wei Dong et al.   Oncotarget

The degradation of mixed lineage kinase domain-like protein promotes neuroprotection after ischemic brain injury

(2017) Yanlong Zhou et al.   Oncotarget

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

(2016) Ulrike Höckendorf et al.   CANCER CELL

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

(2016) Kevin D. McCormick et al.   CARCINOGENESIS

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Necrosome core machinery: MLKL

(2016) Jing Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system

(2016) Seamus J. Martin   FEBS Journal

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis

(2016) X M Zhao et al.   Cell Death & Disease

Key roles of necroptotic factors in promoting tumor growth

(2016) Xinjian Liu et al.   Oncotarget

Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis

(2016) Dominique Bozec et al.   Oncotarget

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Role of Autophagy in the Maintenance of Intestinal Homeostasis

(2015) Leigh A. Baxt et al.   GASTROENTEROLOGY

The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice

(2015) Zhenyu Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

(2015) Yuichi Tsuchiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer

(2015) Yiming Sun et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB

(2015) M Oliver Metzig et al.   ONCOGENE

The molecular relationships between apoptosis, autophagy and necroptosis

(2015) Najoua Lalaoui et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

(2015) P Geserick et al.   Cell Death & Disease

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

(2015) A Fauster et al.   Cell Death & Disease

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

(2015) K Moriwaki et al.   Cell Death & Disease

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

(2014) Claudia Günther et al.   GUT

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

(2014) J-X Li et al.   Cell Death & Disease

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

(2014) A-L Nugues et al.   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

(2013) A. Lau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Control of Life-or-Death Decisions by RIP1 Kinase

(2013) Dana E Christofferson et al.   Annual Review of Physiology

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

(2013) C-Y Huang et al.   Cell Death & Disease

Structural Insights into RIP3-Mediated Necroptotic Signaling

(2013) Tian Xie et al.   Cell Reports

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

(2012) A Degterev et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia

(2012) Huashan Ye et al.   NUCLEIC ACIDS RESEARCH

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of necroptosis in T cells

(2011) Irene L. Ch’en et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

(2011) J. V. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1

(2010) Jia Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL