Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

(2012) María P. Torres et al.   CANCER LETTERS

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1

(2012) Kohei Matsushita et al.   JOURNAL OF PEDIATRIC SURGERY

Neutrophil priming by hypoxic preconditioning protects against epithelial barrier damage and enteric bacterial translocation in intestinal ischemia/reperfusion

(2012) Yen-Zhen Lu et al.   LABORATORY INVESTIGATION

Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

(2012) Annamaria Rapisarda et al.   Nature Reviews Clinical Oncology

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Epithelial inducible nitric oxide synthase causes bacterial translocation by impairment of enterocytic tight junctions via intracellular signals of Rho-associated kinase and protein kinase C zeta*

(2011) Li-Ling Wu et al.   CRITICAL CARE MEDICINE

Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression

(2011) Meike de Wit et al.   GUT

The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

(2011) María Sánchez-Aragó et al.   Journal of Translational Medicine

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Coexpression of SGLT1 and EGFR is associated with tumor differentiation in oral squamous cell carcinoma

(2011) Yasuko Hanabata et al.   Odontology

Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays

(2010) Rachel Airley et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Regulation of Na+-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein

(2010) Natalie Leiprecht et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds

(2010) Kenneth K. Kao et al.   BIOCHEMICAL PHARMACOLOGY

Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death

(2010) A Garedew et al.   CELL DEATH AND DIFFERENTIATION

Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase

(2010) L Zeng et al.   ENDOCRINE-RELATED CANCER

Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia

(2010) Ching-Ying Huang et al.   LABORATORY INVESTIGATION

Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis

(2010) Gui Fang Guo et al.   MEDICAL ONCOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

(2008) Nektaria Simiantonaki et al.   BMC CANCER

Expression of SGLT1, Bcl-2 and p53 in Primary Pancreatic Cancer Related to Survival

(2008) Veerle F. Casneuf et al.   CANCER INVESTIGATION

Hypoxia-inducible factor 1α under rapid enzymatic hypoxia: Cells sense decrements of oxygen but not hypoxia per se

(2008) Gunda Millonig et al.   FREE RADICAL BIOLOGY AND MEDICINE

SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis

(2008) Linda C.H. Yu et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum

(2008) Astrid E. Greijer et al.   VIRCHOWS ARCHIV