Current translational potential and underlying molecular mechanisms of necroptosis

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression

(2019) Yu Xiong et al.   CELL DEATH AND DIFFERENTIATION

MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway

(2019) Huojun Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis

(2019) J. Shi et al.   Scientific Reports

Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway

(2019) Jiabin Zhou et al.   INVESTIGATIONAL NEW DRUGS

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

(2019) Xinghui Li et al.   IMMUNITY

Rapamycin Inhibited Photoreceptor Necroptosis and Protected the Retina by Activation of Autophagy in Experimental Retinal Detachment

(2019) Jie Ding et al.   CURRENT EYE RESEARCH

Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation

(2019) Jingyi Chen et al.   CARDIOVASCULAR DRUGS AND THERAPY

The role of necroptosis in cancer: A double-edged sword?

(2019) Xia Qin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Identification of the Raf kinase inhibitor TAK‐632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3

(2019) Xiaofei Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Plasma Levels of Receptor Interacting Protein Kinase-3 Correlated with Coronary Artery Disease

(2019) Xiao-Min Hu et al.   CHINESE MEDICAL JOURNAL

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

(2019) Cristina Florean et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation

(2019) Chaohuan Guo et al.   JOURNAL OF AUTOIMMUNITY

FKBP12 mediates necroptosis by initiating RIPK1–RIPK3–MLKL signal transduction in response to TNF receptor 1 ligation

(2019) Zicheng Wang et al.   JOURNAL OF CELL SCIENCE

Inhibition of mixed lineage kinase domain like pseudokinase decreases fat de novo synthesis and chemokine ligand expression in non‐alcoholic fatty liver disease

(2019) Waqar Khalid Saeed et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

(2019) Weiliang Fan et al.   Science Signaling

TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis

(2019) Jie Li et al.   Cell Death & Disease

Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells

(2019) Chong Zhang et al.   Cell Death & Disease

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

(2019) Yves Dondelinger et al.   Nature Communications

Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis

(2019) Choi et al.   Cells

Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis

(2019) Rania Nagi Abd-Ellatif et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A common variant of RIP3 promoter region is associated with poor prognosis in heart failure patients by influencing SOX17 binding

(2019) Dong Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Extracts derived from a traditional Chinese herbal formula triggers necroptosis in ectocervical Ect1/E6E7 cells through activation of RIP1 kinase

(2019) Xiaofeng Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

(2019) Ayaz Najafov et al.   MOLECULAR CELL

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

(2019) Annelise G. Snyder et al.   Science Immunology

Kinase-independent role of nuclear RIPK1 in regulating parthanatos through physical interaction with PARP1 upon oxidative stress

(2018) Ki-Hong Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prognostic and clinicopathological significance of MLKL expression in cancer patients: a meta-analysis

(2018) Binwu Hu et al.   BMC CANCER

Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma

(2018) Yulin Sun et al.   CANCER LETTERS

MLKL-PITPα signaling-mediated necroptosis contributes to cisplatin-triggered cell death in lung cancer A549 cells

(2018) Lin Jing et al.   CANCER LETTERS

Bufalin inhibits human breast cancer tumorigenesis by inducing cell death through the ROS-mediated RIP1/RIP3/PARP-1 pathways

(2018) Yanlan Li et al.   CARCINOGENESIS

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

(2018) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

(2018) Joseph Sarhan et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis

(2018) Delong Jiao et al.   CELL RESEARCH

Caspase-2 is a negative regulator of necroptosis

(2018) Alexey V. Zamaraev et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression

(2018) Zhen Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis

(2018) Felix Lauffer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Necroptosis in cardiovascular disease - a new therapeutic target

(2018) Kartik Gupta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis

(2018) Qinrui Han et al.   Journal of Translational Medicine

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation

(2018) Seung-Won Choi et al.   MOLECULAR CELL

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

(2018) Alessandro Annibaldi et al.   MOLECULAR CELL

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

(2018) Cole M. Dovey et al.   MOLECULAR CELL

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism

(2018) Wenjing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BiallelicRIPK1mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

(2018) Delphine Cuchet-Lourenço et al.   SCIENCE

Necroptosis and neutrophil-associated disorders

(2018) Xiaoliang Wang et al.   Cell Death & Disease

RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

(2018) Sofie Martens et al.   Cell Death & Disease

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis

(2018) Norah A. Alturki et al.   Cell Death & Disease

Proteasome inhibition blocks necroptosis by attenuating death complex aggregation

(2018) Mohammad Ali et al.   Cell Death & Disease

Phenytoin inhibits necroptosis

(2018) Anne von Mässenhausen et al.   Cell Death & Disease

Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1

(2018) Yu Wang et al.   Cell Death & Disease

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation

(2018) Sara Nikseresht et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation

(2018) Pedro Elói Antunes Dionísio et al.   MOLECULAR NEUROBIOLOGY

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity

(2018) Zhifei Xu et al.   TOXICOLOGY LETTERS

Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis

(2018) Miho Akimoto et al.   Cell Death & Disease

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

(2018) Lucia Taraborrelli et al.   Nature Communications

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

(2018) Dan E. McNamara et al.   Jove-Journal of Visualized Experiments

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells

(2018) Yan Jia et al.   Redox Biology

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2018) Wei Wang et al.   CANCER CELL

Comparing the effects of different cell death programs in tumor progression and immunotherapy

(2018) Michelle N. Messmer et al.   CELL DEATH AND DIFFERENTIATION

The anticonvulsive Phenhydan® suppresses extrinsic cell death

(2018) Caroline Moerke et al.   CELL DEATH AND DIFFERENTIATION

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells

(2018) Heng-Long Wang et al.   MOLECULES

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

(2018) Yue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

(2018) Anne-Kathrin Knuth et al.   NEOPLASIA

Genipin protects d -galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling

(2017) Min-Jong Seo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis

(2017) Fucheng Luo et al.   EXPERIMENTAL NEUROLOGY

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

(2017) Yangchun Xie et al.   GASTROENTEROLOGY

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

(2017) Ran Wei et al.   GENES & DEVELOPMENT

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

A novel damage mechanism: Contribution of the interaction between necroptosis and ROS to high glucose-induced injury and inflammation in H9c2 cardiac cells

(2017) Weijie Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)–mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

(2017) Susanne Radonjic-Hoesli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis

(2017) Eduardo Reynoso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD3+ CD8+ NKG2D+ T Lymphocytes Induce Apoptosis and Necroptosis in HLA-Negative Cells via FasL-Fas Interaction

(2017) Olga K. Ivanova et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis

(2017) Chengxian Xu et al.   JOURNAL OF IMMUNOLOGY

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

(2017) Holly Anderton et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

(2017) Hyo-Jin Kim et al.   Journal of Translational Medicine

Analysis of necroptotic proteins in failing human hearts

(2017) Adrián Szobi et al.   Journal of Translational Medicine

Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis

(2017) Xiao-Ming Meng et al.   LABORATORY INVESTIGATION

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

(2017) Sharan R. Srinivasan et al.   MOLECULAR CANCER RESEARCH

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

(2017) Slawomir A. Dziedzic et al.   NATURE CELL BIOLOGY

LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis

(2017) Ying Wang et al.   NEUROCHEMICAL RESEARCH

Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism

(2017) Chang Qu et al.   PHARMACOLOGICAL RESEARCH

PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP

(2017) Huibing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

(2017) Adrian Schreiber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis

(2017) Chengkui Yang et al.   Cell Death & Disease

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

(2017) Sofie Martens et al.   Cell Death & Disease

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

(2017) Yi Qu et al.   Cell Death & Disease

The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited

(2017) Qing Xu et al.   Nature Communications

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Die later with ESCRT!

(2017) Wulf Tonnus et al.   Oncotarget

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter

(2017) Zhentao Yang et al.   Cell Reports

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd -Deficient Mice

(2017) Qun Zhao et al.   Cell Reports

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

(2017) Uris Ros et al.   Cell Reports

Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death

(2017) Anne Schroeder et al.   Scientific Reports

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

Proteasome inhibitor PS-341 limits macrophage necroptosis by promoting cIAPs-mediated inhibition of RIP1 and RIP3 activation

(2016) Yuchen Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

(2016) Zhenyu Cai et al.   CELL RESEARCH

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Generation of small molecules to interfere with regulated necrosis

(2016) Alexei Degterev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

(2016) Sebastian A Wagner et al.   EMBO JOURNAL

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1

(2016) Christiane Koppe et al.   HEPATOLOGY

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis

(2016) Timothy J. LaRocca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells

(2016) Zhirui Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

(2016) Xiaoliang Wang et al.   JOURNAL OF IMMUNOLOGY

Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

(2016) Farinoosh Fakharnia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells

(2016) Justyna Sosna et al.   MOLECULAR AND CELLULAR BIOLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner

(2016) Zhai Ertao et al.   TUMOR BIOLOGY

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis

(2016) X M Zhao et al.   Cell Death & Disease

Post-translational modifications as key regulators of TNF-induced necroptosis

(2016) X Liu et al.   Cell Death & Disease

TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints

(2016) Xiaoyun Guo et al.   Cell Death & Disease

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

(2016) A V Jacobsen et al.   Cell Death & Disease

Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target

(2016) A Cougnoux et al.   Cell Death & Disease

Activation of necroptosis in human and experimental cholestasis

(2016) Marta B Afonso et al.   Cell Death & Disease

Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control

(2016) Pravin Kesarwani et al.   Oncotarget

MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome

(2016) Xixi Zhang et al.   Cell Reports

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

(2016) Luigi Tortola et al.   Cell Reports

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

The serine threonine kinase RIP3: lost and found

(2015) Michael J. Morgan et al.   BMB Reports

Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway

(2015) Xin Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRAF2 is a biologically important necroptosis suppressor

(2015) S L Petersen et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it

(2015) S Yoon et al.   CELL DEATH AND DIFFERENTIATION

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Receptor-Interacting Protein Kinase 3 Contributes to Abdominal Aortic Aneurysms via Smooth Muscle Cell Necrosis and Inflammation

(2015) Q. Wang et al.   CIRCULATION RESEARCH

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

TAK1 selective inhibition: state of the art and future opportunities

(2015) Iain Kilty et al.   Future Medicinal Chemistry

Upregulated RIP3 Expression Potentiates MLKL Phosphorylation–Mediated Programmed Necrosis in Toxic Epidermal Necrolysis

(2015) Sue Kyung Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway

(2015) Dominique Bollino et al.   JOURNAL OF NEUROCHEMISTRY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

(2015) Wanze Chen et al.   NATURE CELL BIOLOGY

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death

(2015) B Schenk et al.   ONCOGENE

Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB

(2015) M Oliver Metzig et al.   ONCOGENE

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

(2015) M C de Almagro et al.   Cell Death & Disease

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

(2015) A Fauster et al.   Cell Death & Disease

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

(2015) Jason Karch et al.   PLoS One

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

TAK1 control of cell death

(2014) S R Mihaly et al.   CELL DEATH AND DIFFERENTIATION

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

(2014) S Orozco et al.   CELL DEATH AND DIFFERENTIATION

The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation

(2014) Lisheng Li et al.   CELL RESEARCH

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Cathepsins Limit Macrophage Necroptosis through Cleavage of Rip1 Kinase

(2014) S. McComb et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins

(2014) September R. Mihaly et al.   PLoS One

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages

(2014) S. McComb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis, in vivo detection in experimental disease models

(2014) Sandrine Jouan-Lanhouet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77

(2014) Yuhao Luo et al.   TUMOR BIOLOGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

(2014) J-X Li et al.   Cell Death & Disease

Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus

(2014) H Fan et al.   Cell Death & Disease

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis

(2014) I Karl et al.   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways

(2013) Di Wang et al.   APOPTOSIS

Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis

(2013) Thomas McQuade et al.   BIOCHEMICAL JOURNAL

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

(2013) Zeze Fu et al.   BMC CANCER

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis

(2013) Justyna Sosna et al.   Cell Communication and Signaling

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

(2013) F Basit et al.   CELL DEATH AND DIFFERENTIATION

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

(2013) Justyna Sosna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The in vivo significance of necroptosis: Lessons from exploration of caspase-8 function

(2013) David Wallach et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

(2013) Wanze Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

(2013) C-Y Huang et al.   Cell Death & Disease

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

(2013) Q Deng et al.   Cell Death & Disease

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis

(2012) Maria Feoktistova et al.   CELL CYCLE

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death

(2012) Yun-Suk Lee et al.   FEBS LETTERS

NEMO Inhibits Programmed Necrosis in an NFκB-Independent Manner by Restraining RIP1

(2012) Marie Anne O’Donnell et al.   PLoS One

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The targeted inhibition of mitochondrial Hsp90 overcomes the apoptosis resistance conferred by Bcl-2 in Hep3B cells via necroptosis

(2012) Chunlan Yan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis

(2012) Eun-Woo Lee et al.   Nature Communications

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

(2011) Marion C. Bonnet et al.   IMMUNITY

Mechanisms of necroptosis in T cells

(2011) Irene L. Ch’en et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons

(2011) Wei-Wei Chen et al.   JOURNAL OF NEUROCHEMISTRY

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

(2011) R. J. Thapa et al.   MOLECULAR AND CELLULAR BIOLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)

(2011) Mathieu J. M. Bertrand et al.   PLoS One

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

(2011) J. V. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers

(2011) Matthew A. Nehs et al.   SURGERY

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

(2011) N Vanlangenakker et al.   Cell Death & Disease

The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

(2010) Xingshun Xu et al.   BRAIN RESEARCH

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Bcl-2-regulated cell death signalling in the prevention of autoimmunity

(2010) D Tischner et al.   Cell Death & Disease

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

NEMO/IKKγ regulates an early NF-κB-independent cell-death checkpoint during TNF signaling

(2009) D Legarda-Addison et al.   CELL DEATH AND DIFFERENTIATION

Transforming Growth Factor β-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

(2009) Peter Broglie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Multiple roles for nuclear localization signal (NLS, aa 442–472) of receptor interacting protein 3 (RIP3)

(2008) Mei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL