Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+Uptake and Promotes Colorectal Oncogenesis

(2018) Fanxin Zeng et al.   CANCER RESEARCH

Interleukin-6 and interleukin-8 serum levels in prognosis of hormone-dependent breast cancer

(2018) Jelena Milovanović et al.   CYTOKINE

DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis

(2018) Qian Liu et al.   Journal of Hematology & Oncology

HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

(2018) Sijia He et al.   Cell Death & Disease

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

(2017) Trieu-My Van et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RIP1 Kinase Is an Oncogenic Driver in Melanoma

(2015) X. Y. Liu et al.   CANCER RESEARCH

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it

(2015) S Yoon et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers

(2014) G. N. Gan et al.   CANCER RESEARCH

Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma

(2014) Jin Cheng et al.   Molecular Oncology

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

New components of the necroptotic pathway

(2012) Zhenru Zhou et al.   Protein & Cell

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

(2011) K J Harrington et al.   BRITISH JOURNAL OF CANCER

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers

(2011) Matthew A. Nehs et al.   SURGERY

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology