Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?

Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways

(2020) Arulkumar Nagappan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Sadaf G Sepanlou et al.   Lancet Gastroenterology & Hepatology

Long non-coding RNA H19 in the liver-gut axis: A diagnostic marker and therapeutic target for liver diseases

(2020) Xiaojiaoyang Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis

(2020) Marina Barcena-Varela et al.   GUT

Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha

(2020) Ya-Ling Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats

(2020) Amit Kundu et al.   Cells

Safety and Tolerability of Histone Deacetylase (HDAC) Inhibitors in Oncology

(2019) Rashmi R. Shah   DRUG SAFETY

Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway

(2019) Rui Jiang et al.   LIFE SCIENCES

Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

(2019) Runping Liu et al.   HEPATOLOGY

Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis

(2019) Marina Barcena-Varela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activated Hepatic Stellate Cells and Portal Fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice

(2019) Takahiro Nishio et al.   JOURNAL OF HEPATOLOGY

The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription

(2019) Ming Kong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitors Of Class I Histone Deacetylases Attenuate Thioacetamide-Induced Liver Fibrosis In Mice By Suppressing Hepatic Type 2 Inflammation

(2019) Zhixuan Loh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fibrogenic Activity of MECP2 is Regulated by Phosphorylation in Hepatic Stellate Cells

(2019) Eva Moran-Salvador et al.   GASTROENTEROLOGY

miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression

(2019) Song Wei et al.   Molecular Therapy-Nucleic Acids

Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling

(2019) Yuqin Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy pathway

(2019) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12

(2018) Büsra Öztürk Akcora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Beneficial effects of Cilostazol on liver injury induced by common bile duct ligation in rats: Role of SIRT1 signaling pathway

(2018) Soad L Kabil   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

Effect of histone deacetylase inhibitor on epithelial-mesenchymal transition of liver fibrosis

(2018) Maggie M. Ramzy et al.   IUBMB LIFE

Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis

(2018) Huanyu Zhao et al.   PHARMACOLOGICAL RESEARCH

Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-β-Smad signaling pathway

(2018) Fayang Zhou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis

(2018) Jing-Jing Yang et al.   TOXICOLOGY LETTERS

MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

(2018) Liping Ma et al.   Cell Death & Disease

Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro

(2018) Di Ding et al.   Scientific Reports

p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

(2018) Weilei Yao et al.   Biomed Research International

MicroRNA-125b Promotes Hepatic Stellate Cell Activation and Liver Fibrosis by Activating RhoA Signaling

(2018) Kai You et al.   Molecular Therapy-Nucleic Acids

Histone deacetylase inhibitor suberoylanilide hydroxamic acid alleviates liver fibrosis by suppressing the transforming growth factor-β1 signal pathway

(2018) Yao Wang et al.   Hepatobiliary & Pancreatic Diseases International

γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis

(2018) Anqi Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats

(2018) Haoyang Zhu et al.   Canadian Journal of Gastroenterology and Hepatology

The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway

(2018) Fangyuan Dong et al.   EBioMedicine

EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis

(2017) Yang Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells

(2017) Yue Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A

(2017) Müjdat Zeybel et al.   MOLECULAR THERAPY

TET-mediated active DNA demethylation: mechanism, function and beyond

(2017) Xiaoji Wu et al.   NATURE REVIEWS GENETICS

Epigenetics in Liver Fibrosis

(2017) Veronica Massey et al.   SEMINARS IN LIVER DISEASE

Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1)

(2017) Dalia M. Abd El Motteleb et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy

(2017) Ming Chen et al.   FEBS Open Bio

Inhibition of SIRT2 suppresses hepatic fibrosis

(2016) Maribel Arteaga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence

(2016) Feng Zhang et al.   CELL BIOLOGY INTERNATIONAL

The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis

(2016) Daniel Karin et al.   DIFFERENTIATION

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

(2016) Wenfang Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape

(2016) Agata Page et al.   JOURNAL OF HEPATOLOGY

Sodium valproate, a histone deacetylase inhibitor, with praziquantel ameliorates Schistosoma mansoni -induced liver fibrosis in mice

(2016) Mohamed G. Elsakkar et al.   LIFE SCIENCES

Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis

(2016) Xing Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury

(2016) Yong Yang et al.   TOXICOLOGY LETTERS

Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis

(2016) Mio Kitano et al.   Journal of Clinical Medicine

Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

(2016) Lina Sun et al.   Scientific Reports

Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis

(2015) Pei-Jie Chen et al.   BIOCHIMIE

Bone marrow-derived fibrocytes contribute to liver fibrosis

(2015) Jun Xu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor γ

(2015) Yan Jiang et al.   FASEB JOURNAL

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells

(2015) Agata Page et al.   JOURNAL OF HEPATOLOGY

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

(2015) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells

(2015) Adil El Taghdouini et al.   Oncotarget

Suberoylanilide hydroxamic acid suppresses hepatic stellate cells activation by HMGB1 dependent reduction of NF-κB1

(2015) Wenwen Wang et al.   PeerJ

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

(2015) Yosuke Osawa et al.   EBioMedicine

Epigenetic Changes during Hepatic Stellate Cell Activation

(2015) Silke Götze et al.   PLoS One

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

(2015) Ying-Hsien Huang et al.   PLoS One

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

(2014) Ki Cheong Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Playing TETris with DNA modifications

(2014) B. Delatte et al.   EMBO JOURNAL

Valproate ameliorates thioacetamide-induced fibrosis by hepatic stellate cell inactivation

(2014) JS Aher et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells

(2014) Cheng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway

(2014) Jianjian Zheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

NF-κB inhibition alleviates carbon tetrachloride-induced liver fibrosis via suppression of activated hepatic stellate cells

(2014) FEI WANG et al.   Experimental and Therapeutic Medicine

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

(2013) Yulia A. Nevzorova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Histone deacetylases as targets for treatment of multiple diseases

(2013) Jinhua Tang et al.   CLINICAL SCIENCE

Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29

(2013) Inge Mannaerts et al.   PLoS One

Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats

(2013) Er-Bao Bian et al.   TOXICOLOGY LETTERS

miR-181b Promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients

(2012) Baocan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global analysis of DNA methylation in early-stage liver fibrosis

(2012) Yoko Komatsu et al.   BMC Medical Genomics

Epigenetic regulation of wound healing and fibrosis

(2012) Jelena Mann et al.   CURRENT OPINION IN RHEUMATOLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation

(2012) Maria Jesus Perugorria et al.   HEPATOLOGY

Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice

(2012) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling

(2012) Yuqing Liu et al.   LIVER INTERNATIONAL

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

(2012) Julia Arand et al.   PLoS Genetics

Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line

(2011) Toshifumi Watanabe   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300

(2011) Joong-Yeon Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4

(2010) Lan Qin et al.   AMERICAN JOURNAL OF PATHOLOGY

Histone deacetylase inhibition suppresses the transforming growth factor β1-induced epithelial-to-mesenchymal transition in hepatocytes

(2010) Aki Kaimori et al.   HEPATOLOGY

Valproic acid administration for hepatic fibrosis: A balance between antifibrotic efficacy and hepatotoxicity

(2010) Yoshihiro Ikura et al.   HEPATOLOGY

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders

(2010) M. Pang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways

(2009) Can-Jie Guo et al.   FEBS Journal

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cellsin vitroandin vivo

(2009) Inge Mannaerts et al.   HEPATOLOGY

Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology

(2009) Fraczek Joanna et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

(2009) J. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling

(2008) Yuqing Liu et al.   LABORATORY INVESTIGATION

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

(2007) Jason H. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY