TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Modifications of Telomerase (TERT) Gene in Hepatocellular Carcinoma Cells

(2014) Bin Zhang et al.   PLoS One

Failure of Fibrotic Liver Regeneration in Mice Is Linked to a Severe Fibrogenic Response Driven by Hepatic Progenitor Cell Activation

(2013) Kaori Kuramitsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Stressing the cell cycle in senescence and aging

(2013) Hollie Chandler et al.   CURRENT OPINION IN CELL BIOLOGY

Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses

(2013) Janina E.E. Tirnitz-Parker et al.   HEPATOLOGY

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver Disease

(2013) Aloysious Aravinthan et al.   PLoS One

A New Strategy for Treatment of Liver Fibrosis

(2012) Shao-Long Chen et al.   BIODRUGS

Role of cellular senescence in hepatic wound healing and carcinogenesis

(2012) Gayatri Ramakrishna et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence

(2011) Seok Young Jang et al.   FEBS LETTERS

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

(2011) Linda C. Burkly et al.   IMMUNOLOGICAL REVIEWS

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

To TWEAK, or not to TWEAK: That is the question

(2010) David A. Shafritz   HEPATOLOGY

Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells

(2010) Janina E. E. Tirnitz-Parker et al.   HEPATOLOGY

Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury

(2010) Kiyohiko Hotta et al.   KIDNEY INTERNATIONAL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY