p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

The growth hormone signaling system: Insights into coordinating the anabolic and catabolic actions of growth hormone

(2018) Heather E. Bergan-Roller et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Lipid Emulsion Added to a Liquid High-Carbohydrate Diet and Voluntary Running Exercise Reduce Lipogenesis and Ameliorate Early-Stage Hepatic Steatosis in Mice

(2017) Kuan-Hsun Huang et al.   JOURNAL OF NUTRITION

Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions

(2017) Niluka Goonawardane et al.   JOURNAL OF VIROLOGY

Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly

(2017) Juliano G. Haddad et al.   JOURNAL OF VIROLOGY

CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis

(2017) Hyunbae Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes

(2017) Jaewoong Jang et al.   Molecular Medicine Reports

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP

(2017) Tsung-Yuan Tsai et al.   Scientific Reports

Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes

(2017) Yuanyuan Shi et al.   PLoS One

Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction

(2017) Chao Yang et al.   Scientific Reports

Liver glycogen metabolism during and after prolonged endurance-type exercise

(2016) Javier T. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sirt1: Role Under the Condition of Ischemia/Hypoxia

(2016) Xiaofei Meng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Microbial contributions to chronic inflammation and metabolic disease

(2016) Fergus Shanahan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells

(2016) Ning Wang et al.   Evidence-based Complementary and Alternative Medicine

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

(2016) Wenfang Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

β-Apo-10′-carotenoids Modulate Placental Microsomal Triglyceride Transfer Protein Expression and Function to Optimize Transport of Intact β-Carotene to the Embryo

(2016) Brianna K. Costabile et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target-gene expression

(2016) Laura E. Downing et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets

(2016) Rafael T. Mattos et al.   PLoS One

Erratum: Corrigendum: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

(2016) Lina Sun et al.   Scientific Reports

MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis

(2015) Zhiwen Fan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target

(2015) Lei Zhan et al.   BIOCHIMIE

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

(2015) Thomas K. Sin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protein Lysine Acetylation by p300/CBP

(2015) Beverley M. Dancy et al.   CHEMICAL REVIEWS

ChREBP and LXRα mediate synergistically lipogenesis induced by glucose in porcine adipocytes

(2015) Guo Hua Zhang et al.   GENE

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

(2015) Mohamed Asrih et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sterol Regulatory Element Binding Transcription Factor-1 Gene Variation and Medication Load Influence White Matter Structure in Schizophrenia

(2015) Irene Bollettini et al.   NEUROPSYCHOBIOLOGY

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

(2015) Pedro Gomes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish

(2015) Yeon-Joo Lee et al.   Food & Function

Regulation of Liver Metabolism by the Endosomal GTPase Rab5

(2015) Anja Zeigerer et al.   Cell Reports

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

(2015) Yosuke Osawa et al.   EBioMedicine

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

(2014) Kyoung-Jin Oh et al.   BMB Reports

Safely targeting cancer stem cells via selective catenin coactivator antagonism

(2014) Heinz-Josef Lenz et al.   CANCER SCIENCE

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

(2014) Antoinette Bugyei-Twum et al.   Cardiovascular Diabetology

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Mechanisms Underlying the Link between Non-Alcoholic Fatty Liver Diseases and Nutrition

(2014) Joo Lee et al.   Nutrients

The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study

(2014) L. Webber et al.   BMJ Open

Canonical Wnt signalling as a key regulator of fibrogenesis - implications for targeted therapies?

(2013) Clara Dees et al.   EXPERIMENTAL DERMATOLOGY

Control ofFoxo1Gene Expression by Co-activator P300

(2013) Anne R. Wondisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling

(2013) G. Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

Activation of Basal Gluconeogenesis by Coactivator p300 Maintains Hepatic Glycogen Storage

(2013) Ling He et al.   MOLECULAR ENDOCRINOLOGY

A Novel Function of Novobiocin: Disrupting the Interaction of HIF 1α and p300/CBP through Direct Binding to the HIF1α C-Terminal Activation Domain

(2013) Donglu Wu et al.   PLoS One

Transcriptional Co-activator p300 Maintains Basal Hepatic Gluconeogenesis

(2012) Ling He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pretransplant Prediction of Posttransplant Survival for Liver Recipients with Benign End-Stage Liver Diseases: A Nonlinear Model

(2012) Ming Zhang et al.   PLoS One

Dietary Regulation of Histone Acetylases and Deacetylases for the Prevention of Metabolic Diseases

(2012) Tho Pham et al.   Nutrients

p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle

(2011) Sarah M. Senf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Regulation of microsomal triglyceride transfer protein

(2011) M Mahmood Hussain et al.   Clinical Lipidology

Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

(2011) Mehdi Shakibaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells

(2011) Erica Novo et al.   JOURNAL OF PATHOLOGY

Nutritional influences on epigenetics and age-related disease

(2011) Lara K. Park et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models

(2010) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor

(2010) Kyung-Chul Choi et al.   BIOCHEMICAL JOURNAL

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

(2010) Min-Woo Lee et al.   Cell Metabolism

Genetic control ofde novolipogenesis: role in diet-induced obesity

(2010) Maggie S. Strable et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy

(2010) R. A. Rizza   DIABETES

Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo

(2010) C. J. Ramnanan et al.   DIABETES

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

(2010) Li Qiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin

(2010) Jung-Mi Yun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of intermediary metabolism by protein acetylation

(2010) Kun-Liang Guan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

(2009) Maziyar Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

(2009) Jeon-OK Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

Role of Wnt/β-catenin signaling in liver metabolism and cancer

(2009) Satdarshan Pal Singh Monga   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4α

(2009) Jianqi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

(2008) David Saggerson   Annual Review of Nutrition

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP

(2008) Sungsoon Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE