Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha

MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice

(2019) Ya-Ling Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices

(2019) Emilia Gore et al.   BIOCHEMICAL PHARMACOLOGY

PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury

(2019) Wei Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of the ER stress response by a mitochondrial microprotein

(2019) Qian Chu et al.   Nature Communications

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

(2019) Mengyun Duan et al.   Journal of Immunology Research

MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice

(2019) Hung-Yu Lin et al.   Cells

MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice

(2018) Yen-Cheng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway

(2018) Xingran Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice

(2018) Runping Liu et al.   HEPATOLOGY

The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis

(2018) Ying-Hsien Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice

(2017) Ying-Hsien Huang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases

(2017) Ya-Ling Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice

(2016) Yoshinari Matsumoto et al.   MOLECULAR THERAPY

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

(2015) Ying-Hsien Huang et al.   PLoS One

MicroRNA Function in the Profibrogenic Interplay upon Chronic Liver Disease

(2014) Jia Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

MicroRNA-29a protects against acute liver injury in a mouse model of obstructive jaundice via inhibition of the extrinsic apoptosis pathway

(2013) Mao-Meng Tiao et al.   APOPTOSIS

HS-173, a Novel PI3K Inhibitor, Attenuates the Activation of Hepatic Stellate Cells in Liver Fibrosis

(2013) Mi Kwon Son et al.   Scientific Reports

Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture

(2011) Sarmistha Bandyopadhyay et al.   JOURNAL OF INFECTIOUS DISEASES

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response

(2010) Jonathon N Winnay et al.   NATURE MEDICINE

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis

(2009) Gakuhei Son et al.   HEPATOLOGY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS