Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis

The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome

(2019) Hemant Gujar et al.   Genes

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma

(2018) Marina Bárcena-Varela et al.   HEPATOLOGY

Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro

(2018) Di Ding et al.   Scientific Reports

Liquid biopsy for liver diseases

(2018) Jelena Mann et al.   GUT

Histone deacetylase inhibitor suberoylanilide hydroxamic acid alleviates liver fibrosis by suppressing the transforming growth factor-β1 signal pathway

(2018) Yao Wang et al.   Hepatobiliary & Pancreatic Diseases International

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway

(2018) Fangyuan Dong et al.   EBioMedicine

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A

(2017) Müjdat Zeybel et al.   MOLECULAR THERAPY

TET-mediated active DNA demethylation: mechanism, function and beyond

(2017) Xiaoji Wu et al.   NATURE REVIEWS GENETICS

Histone chaperone networks shaping chromatin function

(2017) Colin M. Hammond et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA methylation and DNA methyltransferases

(2017) John R. Edwards et al.   Epigenetics & Chromatin

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

(2017) Edurne San José-Enériz et al.   Nature Communications

Dysregulation of miRNA Expression in Cancer Associated Fibroblasts (CAFs) and Its Consequences on the Tumor Microenvironment

(2017) Maren Schoepp et al.   Cancers

Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings

(2016) Concetta Panebianco et al.   CLINICAL AND EXPERIMENTAL MEDICINE

DNA methylation in fibrosis

(2016) Christopher Dowson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

(2016) Wenfang Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape

(2016) Agata Page et al.   JOURNAL OF HEPATOLOGY

Regulation of hepatocyte identity and quiescence

(2015) Carmen Berasain et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor γ

(2015) Yan Jiang et al.   FASEB JOURNAL

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells

(2015) Agata Page et al.   JOURNAL OF HEPATOLOGY

Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

(2015) Jean-Pierre J Issa et al.   LANCET ONCOLOGY

Matrix metalloproteinases in liver injury, repair and fibrosis

(2015) Sergio Duarte et al.   MATRIX BIOLOGY

Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin

(2015) Yuting Kuang et al.   Molecular Oncology

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Origin and Function of Myofibroblasts in the Liver

(2015) Rebecca Wells et al.   SEMINARS IN LIVER DISEASE

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells

(2015) Adil El Taghdouini et al.   Oncotarget

Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease

(2015) Müjdat Zeybel et al.   Clinical Epigenetics

Epigenetic Changes during Hepatic Stellate Cell Activation

(2015) Silke Götze et al.   PLoS One

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

(2014) Ki Cheong Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

(2014) Xiaojing Yang et al.   CANCER CELL

Playing TETris with DNA modifications

(2014) B. Delatte et al.   EMBO JOURNAL

Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7

(2014) Rajeswara R. Pannem et al.   HEPATOLOGY

Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22

(2014) Yuliang Feng et al.   PLoS One

Binge Ethanol-Induced HDAC3 Down-RegulatesCpt1αExpression Leading to Hepatic Steatosis and Injury

(2013) Irina Kirpich et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases

(2013) Mohamed E. Shaker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Wnt signaling in liver fibrosis: Progress, challenges and potential directions

(2013) Cheng-gui Miao et al.   BIOCHIMIE

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29

(2013) Inge Mannaerts et al.   PLoS One

The role of methyl-CpG binding protein 2 in liver fibrosis

(2013) Er-Bao Bian et al.   TOXICOLOGY

Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats

(2013) Er-Bao Bian et al.   TOXICOLOGY LETTERS

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis

(2012) Elizabeth R. Davies et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Global analysis of DNA methylation in early-stage liver fibrosis

(2012) Yoko Komatsu et al.   BMC Medical Genomics

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Epigenetic regulation of wound healing and fibrosis

(2012) Jelena Mann et al.   CURRENT OPINION IN RHEUMATOLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation

(2012) Maria Jesus Perugorria et al.   HEPATOLOGY

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling

(2012) Yuqing Liu et al.   LIVER INTERNATIONAL

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays

(2012) Wu-Jun Xiong   WORLD JOURNAL OF GASTROENTEROLOGY

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

(2012) Julia Arand et al.   PLoS Genetics

Essential Role of MeCP2 in the Regulation of Myofibroblast Differentiation during Pulmonary Fibrosis

(2011) Biao Hu et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts

(2011) Jian-Sheng Diao et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research

(2011) N Shenker et al.   BRITISH JOURNAL OF CANCER

Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line

(2011) Toshifumi Watanabe   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4

(2010) Lan Qin et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of liver regeneration by growth factors and cytokines

(2010) Friederike Böhm et al.   EMBO Molecular Medicine

Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure

(2010) Chunli Yan et al.   LIVER INTERNATIONAL

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

(2010) Matt J. Barter et al.   MATRIX BIOLOGY

The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes

(2010) Edwin Smith et al.   MOLECULAR CELL

Transcriptional regulation of hepatic stellate cells

(2009) Jelena Mann et al.   ADVANCED DRUG DELIVERY REVIEWS

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cellsin vitroandin vivo

(2009) Inge Mannaerts et al.   HEPATOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS