Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer's disease: 30 years of clinical use

Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress

(2020) Karem H. Alzoubi et al.   PHYSIOLOGY & BEHAVIOR

Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer’s Disease (AD): A Systematic Review and Meta-Analysis

(2019) Ted Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options

(2019) Jeffrey L. Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

The Brain NGF Metabolic Pathway in Health and in Alzheimer’s Pathology

(2019) A. Claudio Cuello et al.   Frontiers in Neuroscience

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

(2019) Sumonto Mitra et al.   Frontiers in Neuroscience

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

ProNGF and Neurodegeneration in Alzheimer’s Disease

(2019) Margaret Fahnestock et al.   Frontiers in Neuroscience

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Cerebrolysin attenuates ethanol-induced spatial memory impairments through inhibition of hippocampal oxidative stress and apoptotic cell death in rats

(2019) Ladan Vaghef et al.   ALCOHOL

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Characterization of 3 PET tracers for Quantification of Mitochondrial and Synaptic function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J

(2019) Ayla Mansur et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of hippocampal volume and serum brain-derived neurotrophic factor as potential diagnostic markers of conversion from amnestic mild cognitive impairment to Alzheimer disease

(2019) Yan Fang et al.   MEDICINE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

(2019) Caitlin S. Latimer et al.   Acta Neuropathologica Communications

APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease

(2019) Vo Van Giau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Causative Links between Protein Aggregation and Oxidative Stress: A Review

(2019) Elise Lévy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

(2019) Magdalena Miranda et al.   Frontiers in Cellular Neuroscience

Nerve Growth Factor Pathobiology During the Progression of Alzheimer’s Disease

(2019) Elliott J. Mufson et al.   Frontiers in Neuroscience

Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer’s disease

(2019) Marion Ortner et al.   BMC Neurology

Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions

(2019) David R. Elmaleh et al.   JOURNAL OF ALZHEIMERS DISEASE

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease

(2019) Krishna L. Bharani et al.   NEUROBIOLOGY OF AGING

Prediction and Classification of Alzheimer’s Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers

(2019) Yubraj Gupta et al.   Frontiers in Computational Neuroscience

Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway

(2019) Xin Guan et al.   Frontiers in Pharmacology

Cerebrolysin enhances the expression of the synaptogenic protein LRRTM4 in the hippocampus and improves learning and memory in senescent rats

(2019) Luis A. Flores-Páez et al.   BEHAVIOURAL PHARMACOLOGY

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease

(2018) Lorraine Hamelin et al.   BRAIN

Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats

(2018) Javad Mahmoudi et al.   BRAIN RESEARCH BULLETIN

Cerebrolysin: a multi-target drug for recovery after stroke

(2018) Michael Brainin   Expert Review of Neurotherapeutics

MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates

(2018) Alan H. Nagahara et al.   GENE THERAPY

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical Trials for Disease-Modifying Therapies in Alzheimer’s Disease: A Primer, Lessons Learned, and a Blueprint for the Future

(2018) Jeffrey Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Aging without Dementia is Achievable: Current Evidence from Epidemiological Research

(2018) Chengxuan Qiu et al.   JOURNAL OF ALZHEIMERS DISEASE

Severity-Related Increase and Cognitive Correlates of Serum VEGF Levels in Alzheimer’s Disease ApoE4 Carriers

(2018) X. Anton Alvarez et al.   JOURNAL OF ALZHEIMERS DISEASE

40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain

(2018) Sriram Gubbi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Postmortem Brain, Cerebrospinal Fluid, and Blood Neurotrophic Factor Levels in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2018) Yang Du et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau

(2018) Lin-Lin Shen et al.   MOLECULAR PSYCHIATRY

Resistance vs resilience to Alzheimer disease

(2018) Eider M. Arenaza-Urquijo et al.   NEUROLOGY

Dendritic Tau in Alzheimer’s Disease

(2018) Arne Ittner et al.   NEURON

The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology

(2018) E. Simon et al.   NEUROSCIENCE

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

(2018) Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effects of neurotrophic therapy (a pilot study)

(2018) I. K. Malashenkova et al.   Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

(2018) Frederic Brosseron et al.   Alzheimers Research & Therapy

The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial

(2018) Cay Anderson-Hanley et al.   Frontiers in Aging Neuroscience

Cerebrolysin: a multi-target drug for recovery after stroke

(2018) Michael Brainin   Expert Review of Neurotherapeutics

Adeno-Associated Viral Vector (Serotype 2)–Nerve Growth Factor for Patients With Alzheimer Disease

(2018) Michael S. Rafii et al.   JAMA Neurology

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Usefulness of EEG Techniques in Distinguishing Frontotemporal Dementia from Alzheimer’s Disease and Other Dementias

(2018) Raffaele Nardone et al.   DISEASE MARKERS

Apathy and APOE4 are associated with Reduced BDNF Levels in Alzheimer's Disease

(2018) Antón Álvarez et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Like Growth Factor-I Receptor Stimulating Activity is Associated with Dementia

(2018) Renée F.A.G. de Bruijn et al.   JOURNAL OF ALZHEIMERS DISEASE

Acute Aerobic Exercise Increases Brain-Derived Neurotrophic Factor Levels in Elderly with Alzheimer's Disease

(2018) Flávia Gomes de Melo Coelho et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of calpain in the neuropathogenesis of Alzheimer’s disease

(2018) Yacoubou Abdoul Razak Mahaman et al.   MEDICINAL RESEARCH REVIEWS

Association of vascular endothelial growth factor levels in CSF and cerebral glucose metabolism across the Alzheimer’s disease spectrum

(2018) Zhaowei Wang et al.   NEUROSCIENCE LETTERS

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

(2018) Fernando Gomez-Pinilla et al.   PROGRESS IN NEUROBIOLOGY

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve

(2018) Sylvie L. Lesuis et al.   Alzheimers Research & Therapy

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

(2018) Garrett S. Gibbons et al.   JAMA Neurology

Alzheimer's Disease, time to turn the tide

(2018) Stefano L. Sensi   Aging-US

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

(2018) Harald Hampel et al.   Nature Reviews Neurology

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

(2018) Isabel Barroeta-Espar et al.   NEUROBIOLOGY OF DISEASE

Painless Nerve Growth Factor: A TrkA biased agonist mediating a broad neuroprotection via its actions on microglia cells

(2018) Antonino Cattaneo et al.   PHARMACOLOGICAL RESEARCH

Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

(2018) Karolina J. Janczura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysin

(2018) Karem.H. Alzoubi et al.   PSYCHIATRY RESEARCH

proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing

(2018) Catherine Fleitas et al.   Molecular Brain

Intranasal Cerebrolysin Attenuates Learning and Memory Impairments in D-galactose-Induced Senescence in Mice

(2017) Ehsan Pourmemar et al.   EXPERIMENTAL GERONTOLOGY

Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease

(2017) Stephen D. Ginsberg et al.   HIPPOCAMPUS

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP

(2017) Saket M. Nigam et al.   JOURNAL OF NEUROCHEMISTRY

Cerebrolysin prevents deficits in social behavior, repetitive conduct, and synaptic inhibition in a rat model of autism

(2017) Roberto Cuevas-Olguin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease

(2017) Hari Shanker Sharma et al.   MOLECULAR NEUROBIOLOGY

The changing prevalence and incidence of dementia over time — current evidence

(2017) Yu-Tzu Wu et al.   Nature Reviews Neurology

Female-specific effect of the BDNF gene on Alzheimer's disease

(2017) Guo-Dong Li et al.   NEUROBIOLOGY OF AGING

Cerebrolysin alleviates cognitive deficits induced by chronic cerebral hypoperfusion by increasing the levels of plasticity-related proteins and decreasing the levels of apoptosis-related proteins in the rat hippocampus

(2017) Zhijuan Liu et al.   NEUROSCIENCE LETTERS

Monoaminergic neuropathology in Alzheimer’s disease

(2017) Goran Šimić et al.   PROGRESS IN NEUROBIOLOGY

Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular dementia

(2017) Patrick Quinlan et al.   PSYCHONEUROENDOCRINOLOGY

Effects of cerebrolysin on nerve growth factor system in the aging rat brain

(2017) Mikhail Stepanichev et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Therapeutic monitoring and prediction of the efficacy of neurotrophic treatment in patients with amnestic type of mild cognitive impairment

(2017) S. I. Gavrilova et al.   Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova

Role of Pro-Inflammatory Cytokines and Vitamin D in Probable Alzheimer's Disease with Depression

(2017) Anindita Banerjee et al.   Aging and Disease

β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men

(2016) Sophie E. Holmes et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Insulin-like growth factor binding protein-2 interactions with Alzheimer’s disease biomarkers

(2016) Elizabeth M. Lane et al.   Brain Imaging and Behavior

Pharmacologic Neuroprotection for Functional Outcomes After Traumatic Brain Injury: A Systematic Review of the Clinical Literature

(2016) Shaun E. Gruenbaum et al.   CNS DRUGS

Cerebrospinal Fluid proNGF: A Putative Biomarker for Early Alzheimer's Disease

(2016) Scott E. Counts et al.   Current Alzheimer Research

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

(2016) L. An et al.   GENETICS AND MOLECULAR RESEARCH

Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases

(2016) X. Anton Alvarez et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Increased Serum miR-206 Level Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer’s Disease: A 5-Year Follow-up Study

(2016) Bing Xie et al.   JOURNAL OF ALZHEIMERS DISEASE

Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer’s Disease

(2016) Jean-Sébastien Vidal et al.   JOURNAL OF ALZHEIMERS DISEASE

BDNF isoforms: a round trip ticket between neurogenesis and serotonin?

(2016) Rocío Beatriz Foltran et al.   JOURNAL OF NEUROCHEMISTRY

A promising therapeutic potential of cerebrolysin in 6-OHDA rat model of Parkinson's disease

(2016) Neveen A. Noor et al.   LIFE SCIENCES

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

11 C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

(2016) William C. Kreisl et al.   NEUROBIOLOGY OF AGING

Higher brainBDNFgene expression is associated with slower cognitive decline in older adults

(2016) Aron S. Buchman et al.   NEUROLOGY

Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice

(2016) Sorabh Sharma et al.   NEUROPHARMACOLOGY

Incidence of Dementia over Three Decades in the Framingham Heart Study

(2016) Claudia L. Satizabal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

(2016) F. E. Matthews et al.   Nature Communications

Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device

(2016) Helga Eyjolfsdottir et al.   Alzheimers Research & Therapy

IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

(2016) Vanesa Nieto-Estévez et al.   Frontiers in Neuroscience

Preserved neurogenesis in non-demented individuals with AD neuropathology

(2016) David Briley et al.   Scientific Reports

Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick’s disease and fronto-temporal tauopathies

(2015) Edward Rockenstein et al.   BMC NEUROSCIENCE

Cerebrolysin in Mild-to-Moderate Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Clinical Trials

(2015) Serge Gauthier et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ

(2015) Jung Yeon Lim et al.   HUMAN MOLECULAR GENETICS

Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed

(2015) Takehiko Doi et al.   NEUROBIOLOGY OF AGING

Brain-derived neurotrophic factor and TrkB expression in the “oldest-old,” the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta

(2015) Bernadeta Michalski et al.   NEUROBIOLOGY OF AGING

Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease

(2015) Edward Rockenstein et al.   Stem Cell Research

The Role of Vascular Endothelial Growth Factor in Neurodegeneration and Cognitive Decline

(2015) Timothy J. Hohman et al.   JAMA Neurology

A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease

(2014) Michael S. Rafii et al.   Alzheimers & Dementia

Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure

(2014) Edward Rockenstein et al.   BMC NEUROSCIENCE

Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling

(2014) Kerstin Hartwig et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

(2014) A. J. Westwood et al.   NEUROLOGY

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

A Large, Cross-Sectional Observational Study of Serum BDNF, Cognitive Function, and Mild Cognitive Impairment in the Elderly

(2014) Hiroyuki Shimada et al.   Frontiers in Aging Neuroscience

Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study

(2013) Chun-Chung Chen et al.   BRITISH JOURNAL OF NEUROSURGERY

Peripheral inflammatory markers in amnestic mild cognitive impairment

(2013) Salman Karim et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction

(2013) Shihui Xing et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Cerebrolysin Ameloriates Cognitive Deficits in Type III Diabetic Rats

(2013) Gehan S. Georgy et al.   PLoS One

Sonic Hedgehog Signaling Pathway Mediates Cerebrolysin-Improved Neurological Function After Stroke

(2013) Li Zhang et al.   STROKE

BDNF mediates adaptive brain and body responses to energetic challenges

(2013) Krisztina Marosi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Symptomatic and Nonamyloid/Tau Based Pharmacologic Treatment for Alzheimer Disease

(2013) P. S. Aisen et al.   Cold Spring Harbor Perspectives in Medicine

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia

(2013) Galit Weinstein et al.   JAMA Neurology

Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults

(2012) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease

(2012) Kiren Ubhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Cerebrolysin in Patients With Acute Ischemic Stroke in Asia

(2012) Wolf-Dieter Heiss et al.   STROKE

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Combination Treatment in Alzheimers Disease: Results of a Randomized, Controlled Trial with Cerebrolysin and Donepezil

(2011) X. A. Alvarez et al.   Current Alzheimer Research

Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease

(2011) Edward Rockenstein et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Effects of Donepezil, Galantamine and Rivastigmine in 938 Italian Patients with Alzheimerʼs Disease

(2010) Aurelia Santoro et al.   CNS DRUGS

Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer’s disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin

(2010) X. A. Alvarez et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neurotrophic factors in Alzheimer’s disease: role of axonal transport

(2010) K. Schindowski et al.   GENES BRAIN AND BEHAVIOR

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke

(2010) Chunling Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cerebrolysin in Vascular Dementia: Improvement of Clinical Outcome in a Randomized, Double-Blind, Placebo-Controlled Multicenter Trial

(2010) Alla B. Guekht et al.   Journal of Stroke & Cerebrovascular Diseases

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin

(2009) Kiren Ubhi et al.   ACTA NEUROPATHOLOGICA

Cerebrolysin

(2009) Greg L. Plosker et al.   DRUGS & AGING

Reduced TNF-α and increased IGF-I levels in the serum of Alzheimer's disease patients treated with the neurotrophic agent Cerebrolysin

(2009) X. Anton Alvarez et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Donepezil delays progression to AD in MCI subjects with depressive symptoms

(2009) P. H. Lu et al.   NEUROLOGY

Progression from mild cognitive impairment to Alzheimerʼs disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment

(2009) Steven Ferris et al.   Pharmacogenetics and Genomics

Role and Therapeutic Potential of VEGF in the Nervous System

(2009) Carmen Ruiz de Almodovar et al.   PHYSIOLOGICAL REVIEWS

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2-385: Cerebrolysin reduces TNF-alpha and soluble TNF receptor-I levels in the serum of Alzheimer's disease patients

(2008) Anton Alvarez et al.   Alzheimers & Dementia

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial

(2008) J. J. Sevigny et al.   NEUROLOGY