40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain

Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review

(2018) Julanne Frater et al.   AGEING RESEARCH REVIEWS

The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging

(2018) Alexandra M.V. Wennberg et al.   NEUROBIOLOGY OF AGING

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

(2018) Sreemathi Logan et al.   Molecular Metabolism

Insulin-Like Growth Factor-I Receptor Stimulating Activity is Associated with Dementia

(2018) Renée F.A.G. de Bruijn et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurotrophic and Neuroregenerative Effects of GH/IGF1

(2017) Vittorio Bianchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer's Disease: Individuals, Dyads, Communities, and Costs

(2017) Christopher M. Callahan   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function

(2017) Joaquín Pardo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The changing prevalence and incidence of dementia over time — current evidence

(2017) Yu-Tzu Wu et al.   Nature Reviews Neurology

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions

(2017) Yuanyuan Liu et al.   NEURON

Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke

(2017) Hamidreza Saber et al.   STROKE

Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms

(2017) Jesse Mu et al.   Frontiers in Aging Neuroscience

A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012

(2017) Kenneth M. Langa et al.   JAMA Internal Medicine

Serum IGF-1 is associated with cognitive functions in early, drug-naïve Parkinson’s disease

(2017) Marina Picillo et al.   PLoS One

Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function

(2016) Leland Perice et al.   Aging-US

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Central IGF-I Receptors in the Brain are Instrumental to Neuroprotection by Systemically Injected IGF-I in a Rat Model for Ischemic Stroke

(2016) Deborah De Geyter et al.   CNS Neuroscience & Therapeutics

Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats

(2016) Joaquín Pardo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer’s Disease

(2016) Jean-Sébastien Vidal et al.   JOURNAL OF ALZHEIMERS DISEASE

Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes

(2016) Anna E. Mattlage et al.   Journal of Stroke & Cerebrovascular Diseases

The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice

(2016) Kendra L. Puig et al.   NEUROBIOLOGY OF AGING

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

(2016) Martin Prince et al.   Alzheimers Research & Therapy

Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes

(2016) Anna E. Mattlage et al.   Journal of Stroke & Cerebrovascular Diseases

IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

(2016) Vanesa Nieto-Estévez et al.   Frontiers in Neuroscience

Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study

(2016) Shankar Tumati et al.   PLoS One

Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer’s Disease

(2016) Philip P. Ostrowski et al.   PLoS One

IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

(2015) Peter Toth et al.   AGING CELL

Metabolic and Non-Cognitive Manifestations of Alzheimer’s Disease: The Hypothalamus as Both Culprit and Target of Pathology

(2015) Makoto Ishii et al.   Cell Metabolism

Growth hormone, insulin-like growth factor-1 and the aging brain

(2015) Nicole M. Ashpole et al.   EXPERIMENTAL GERONTOLOGY

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed

(2015) Takehiko Doi et al.   NEUROBIOLOGY OF AGING

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

(2014) Adam L. Knight et al.   Cell Metabolism

Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats

(2014) Hai-Qing Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IGF-1 Deficiency Impairs Cerebral Myogenic Autoregulation in Hypertensive Mice

(2014) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

(2014) A. J. Westwood et al.   NEUROLOGY

Muscle Atrophy, Voluntary Activation Disturbances, and Low Serum Concentrations of IGF-1 and IGFBP-3 Are Associated With Weakness in People With Chronic Stroke

(2014) M. d. A. Silva-Couto et al.   PHYSICAL THERAPY

Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke

(2014) Jian-Hua Tang et al.   PLoS One

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model

(2013) Edoardo Parrella et al.   AGING CELL

Insulin-like growth factor-1 predicts cognitive functions at 2-year follow-up in early, drug-naïve Parkinson's disease

(2013) M. T. Pellecchia et al.   EUROPEAN JOURNAL OF NEUROLOGY

Insulin-like growth factor-1 and progression of motor symptoms in early, drug-naïve Parkinson’s disease

(2013) Marina Picillo et al.   JOURNAL OF NEUROLOGY

Clinical correlates of serum insulin-like growth factor-1 in patients with Parkinson's disease, multiple system atrophy and progressive supranuclear palsy

(2013) Ayaka Numao et al.   PARKINSONISM & RELATED DISORDERS

Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice

(2013) A Trueba-Sáiz et al.   Translational Psychiatry

Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults

(2012) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Cellular growth factors in relation to mortality from cardiovascular disease in middle-aged Japanese: The JACC study

(2012) Hiroyasu Iso et al.   ATHEROSCLEROSIS

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Insulin-Like Growth Factor Physiology

(2012) Jeff M.P. Holly et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

GH and IGF1: Roles in Energy Metabolism of Long-Living GH Mutant Mice

(2012) H. M. Brown-Borg et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Insulin-Like Growth Factors and Insulin: At the Crossroad Between Tumor Development and Longevity

(2012) R. Novosyadlyy et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

An Antagomir to MicroRNA Let7f Promotes Neuroprotection in an Ischemic Stroke Model

(2012) Amutha Selvamani et al.   PLoS One

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

(2011) Cagdas Tazearslan et al.   AGING CELL

Serum Insulinlike Growth Factor 1 as Possible Marker for Risk and Early Diagnosis of Parkinson Disease

(2011) Jana Godau   ARCHIVES OF NEUROLOGY

IGF1 molecular anomalies demonstrate its critical role in fetal, postnatal growth and brain development

(2011) Irène Netchine et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of Insulin-Like Growth Factor 1 on Muscle Atrophy and Motor Function in Rats with Brain Ischemia

(2011) Heng-Chih Chang   CHINESE JOURNAL OF PHYSIOLOGY

Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke

(2011) Daniel Åberg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging

(2011) L. C. Bailey-Downs et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Reduced brain insulin-like growth factor I function during aging

(2011) Alexandre Pastoris Muller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Insulin-Like Growth Factor I Serum Levels Influence Ischemic Stroke Outcome

(2011) Ann De Smedt et al.   STROKE

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson’s disease

(2010) Farhad Mashayekhi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's disease

(2010) J. Godau et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1

(2010) A. Selvamani et al.   JOURNAL OF NEUROSCIENCE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

(2010) Alessandro Bitto et al.   PLoS One

Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta

(2010) Xin Sun et al.   TOXICOLOGY

Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat

(2009) Praneeti Pathipati et al.   BEHAVIOURAL BRAIN RESEARCH

Longitudinal changes of defensive and offensive factors in focal cerebral ischemia-reperfusion in rats

(2009) Ming Hu et al.   BRAIN RESEARCH BULLETIN

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

The Role of Liver-Derived Insulin-Like Growth Factor-I

(2009) Claes Ohlsson et al.   ENDOCRINE REVIEWS

Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats

(2009) Shuying Lin et al.   EXPERIMENTAL NEUROLOGY

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Intranasal delivery of erythropoietin plus insulin-like growth factor–I for acute neuroprotection in stroke

(2009) Lauren Fletcher et al.   JOURNAL OF NEUROSURGERY

Insulinlike Growth Factor-1, Insulinlike Growth Factor Binding Protein-1, and Cognitive Function in Older Men and Women

(2009) Wael K. Al-Delaimy et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Expanding the Mind: Insulin-Like Growth Factor I and Brain Development

(2008) A. Joseph D'Ercole et al.   ENDOCRINOLOGY

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

(2008) Pär Thored et al.   GLIA

IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP

(2008) Agnès Nadjar et al.   NEUROBIOLOGY OF AGING

Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial

(2008) J. J. Sevigny et al.   NEUROLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Growth Factor-1 Gene Transfer Enhances Neurovascular Remodeling and Improves Long-Term Stroke Outcome in Mice

(2008) Wei Zhu et al.   STROKE

Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models

(2007) Thomas A. Lanz et al.   BIOCHEMICAL PHARMACOLOGY